Biomaterial Database

Alpha-2 adrenergic receptor agonists: a review of current clinical applications. 2015

Joseph A Giovannitti, and Sean M Thoms, and James J Crawford

Professor and Chair and.

The α-2 adrenergic receptor agonists have been used for decades to treat common medical conditions such as hypertension; attention-deficit/hyperactivity disorder; various pain and panic disorders; symptoms of opioid, benzodiazepine, and alcohol withdrawal; and cigarette craving. (1) However, in more recent years, these drugs have been used as adjuncts for sedation and to reduce anesthetic requirements. This review will provide an historical perspective of this drug class, an understanding of pharmacological mechanisms, and an insight into current applications in clinical anesthesiology.

UI	MeSH Term	Description	Entries
D006993	Hypnotics and Sedatives	Drugs used to induce drowsiness or sleep or to reduce psychological excitement or anxiety.	Hypnotic,Sedative,Sedative and Hypnotic,Sedatives,Hypnotic Effect,Hypnotic Effects,Hypnotics,Sedative Effect,Sedative Effects,Sedatives and Hypnotics,Effect, Hypnotic,Effect, Sedative,Effects, Hypnotic,Effects, Sedative,Hypnotic and Sedative
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000759	Adjuvants, Anesthesia	Agents that are administered in association with anesthetics to increase effectiveness, improve delivery, or decrease required dosage.	Anesthesia Adjuvants,Anesthetic Adjuvants,Adjuvants, Anesthetic
D000766	Anesthesia, Dental	A range of methods used to reduce pain and anxiety during dental procedures.	Dental Anesthesia
D000768	Anesthesia, General	Procedure in which patients are induced into an unconscious state through use of various medications so that they do not feel pain during surgery.	Anesthesias, General,General Anesthesia,General Anesthesias
D016292	Conscious Sedation	A drug-induced depression of consciousness during which patients respond purposefully to verbal commands, either alone or accompanied by light tactile stimulation. No interventions are required to maintain a patent airway. (From: American Society of Anesthesiologists Practice Guidelines)	Sedation, Conscious,Sedation, Moderate,Moderate Sedation
D058647	Adrenergic alpha-2 Receptor Agonists	Compounds that bind to and activate ADRENERGIC ALPHA-2 RECEPTORS.	Adrenergic alpha-2 Agonists,Adrenergic alpha-2 Receptor Agonist,Adrenergic alpha2-Agonists,Adrenergic alpha 2 Agonists,Adrenergic alpha 2 Receptor Agonist,Adrenergic alpha 2 Receptor Agonists,Adrenergic alpha2 Agonists,Agonists, Adrenergic alpha-2,alpha-2 Agonists, Adrenergic,alpha2-Agonists, Adrenergic