Induction of antitumor immunity in mice by allo-major histocompatibility complex class I gene transfectant with strong antigen expression. 1989

K Isobe, and Y Hasegawa, and T Iwamoto, and T Hasegawa, and K Kawashima, and L N Ding, and I Nakashima
Department of Immunology, Nagoya University School of Medicine, Japan.

An allo-major histocompatibility complex class I gene (H-2Kb) was transfected to murine mastocytoma P1.HTR (P815 subline) cells, after which several transfectant clones were obtained. Two clones, which expressed a low level of H-2Kb antigen, grew well and killed the syngeneic DBA/2 mice when they were inoculated ip. These mice lived longer than the mice given injections of the parental P1.HTR tumor. However, one clone, which expressed a high level of H-2Kb antigen, was rejected completely by the syngeneic DBA/2 mice and induced a generation of H-2Kb-specific cytotoxic T cells. Interestingly, the mice that had rejected the clone with high H-2Kb expression received strong anti-tumor immunity for rejection of the parental P1.HTR tumor challenged at the high dose.

UI MeSH Term Description Entries
D007942 Leukemia, Experimental Leukemia induced experimentally in animals by exposure to leukemogenic agents, such as VIRUSES; RADIATION; or by TRANSPLANTATION of leukemic tissues. Experimental Leukemia,Experimental Leukemias,Leukemia Model, Animal,Leukemias, Experimental,Animal Leukemia Model,Animal Leukemia Models,Leukemia Models, Animal
D008285 Major Histocompatibility Complex The genetic region which contains the loci of genes which determine the structure of the serologically defined (SD) and lymphocyte-defined (LD) TRANSPLANTATION ANTIGENS, genes which control the structure of the IMMUNE RESPONSE-ASSOCIATED ANTIGENS, HUMAN; the IMMUNE RESPONSE GENES which control the ability of an animal to respond immunologically to antigenic stimuli, and genes which determine the structure and/or level of the first four components of complement. Histocompatibility Complex,Complex, Histocompatibility,Complex, Major Histocompatibility,Complices, Histocompatibility,Complices, Major Histocompatibility,Histocompatibility Complex, Major,Histocompatibility Complices,Histocompatibility Complices, Major,Major Histocompatibility Complices
D008807 Mice, Inbred BALB C An inbred strain of mouse that is widely used in IMMUNOLOGY studies and cancer research. BALB C Mice, Inbred,BALB C Mouse, Inbred,Inbred BALB C Mice,Inbred BALB C Mouse,Mice, BALB C,Mouse, BALB C,Mouse, Inbred BALB C,BALB C Mice,BALB C Mouse
D008810 Mice, Inbred C57BL One of the first INBRED MOUSE STRAINS to be sequenced. This strain is commonly used as genetic background for transgenic mouse models. Refractory to many tumors, this strain is also preferred model for studying role of genetic variations in development of diseases. Mice, C57BL,Mouse, C57BL,Mouse, Inbred C57BL,C57BL Mice,C57BL Mice, Inbred,C57BL Mouse,C57BL Mouse, Inbred,Inbred C57BL Mice,Inbred C57BL Mouse
D008811 Mice, Inbred DBA An inbred strain of mouse. Specific substrains are used in a variety of areas of BIOMEDICAL RESEARCH such as DBA/1J, which is used as a model for RHEUMATOID ARTHRITIS. Mice, DBA,Mouse, DBA,Mouse, Inbred DBA,DBA Mice,DBA Mice, Inbred,DBA Mouse,DBA Mouse, Inbred,Inbred DBA Mice,Inbred DBA Mouse
D009368 Neoplasm Transplantation Experimental transplantation of neoplasms in laboratory animals for research purposes. Transplantation, Neoplasm,Neoplasm Transplantations,Transplantations, Neoplasm
D010957 Plasmids Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS. Episomes,Episome,Plasmid
D002999 Clone Cells A group of genetically identical cells all descended from a single common ancestral cell by mitosis in eukaryotes or by binary fission in prokaryotes. Clone cells also include populations of recombinant DNA molecules all carrying the same inserted sequence. (From King & Stansfield, Dictionary of Genetics, 4th ed) Clones,Cell, Clone,Cells, Clone,Clone,Clone Cell
D006084 Graft Rejection An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient. Transplant Rejection,Rejection, Transplant,Transplantation Rejection,Graft Rejections,Rejection, Graft,Rejection, Transplantation,Rejections, Graft,Rejections, Transplant,Rejections, Transplantation,Transplant Rejections,Transplantation Rejections
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

Related Publications

K Isobe, and Y Hasegawa, and T Iwamoto, and T Hasegawa, and K Kawashima, and L N Ding, and I Nakashima
April 2005, Nihon rinsho. Japanese journal of clinical medicine,
K Isobe, and Y Hasegawa, and T Iwamoto, and T Hasegawa, and K Kawashima, and L N Ding, and I Nakashima
January 1990, Proceedings of the National Academy of Sciences of the United States of America,
K Isobe, and Y Hasegawa, and T Iwamoto, and T Hasegawa, and K Kawashima, and L N Ding, and I Nakashima
January 1996, The Journal of experimental medicine,
K Isobe, and Y Hasegawa, and T Iwamoto, and T Hasegawa, and K Kawashima, and L N Ding, and I Nakashima
November 1987, Molecular and cellular biology,
K Isobe, and Y Hasegawa, and T Iwamoto, and T Hasegawa, and K Kawashima, and L N Ding, and I Nakashima
May 1985, Science (New York, N.Y.),
K Isobe, and Y Hasegawa, and T Iwamoto, and T Hasegawa, and K Kawashima, and L N Ding, and I Nakashima
September 2002, Veterinary immunology and immunopathology,
K Isobe, and Y Hasegawa, and T Iwamoto, and T Hasegawa, and K Kawashima, and L N Ding, and I Nakashima
March 1988, Journal of cellular biochemistry,
K Isobe, and Y Hasegawa, and T Iwamoto, and T Hasegawa, and K Kawashima, and L N Ding, and I Nakashima
January 1994, Annual review of immunology,
K Isobe, and Y Hasegawa, and T Iwamoto, and T Hasegawa, and K Kawashima, and L N Ding, and I Nakashima
April 1987, Journal of reproductive immunology,
K Isobe, and Y Hasegawa, and T Iwamoto, and T Hasegawa, and K Kawashima, and L N Ding, and I Nakashima
September 1989, Journal of neuroimmunology,
Copied contents to your clipboard!