BIOMAT Database Logo BIOMAT Database Logo

Substance p regulates puberty onset and fertility in the female mouse. 2015

Serap Simavli, and Iain R Thompson, and Caroline A Maguire, and John C Gill, and Rona S Carroll, and Andrew Wolfe, and Ursula B Kaiser, and Víctor M Navarro
Division of Endocrinology, Diabetes and Hypertension (S.S., I.R.T., C.A.M., J.C.G., R.S.C., U.B.K., V.M.N.), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115; and Department of Pediatrics (A.W.), Johns Hopkins University School of Medicine, Baltimore, Maryland 21287.

Puberty is a tightly regulated process that leads to reproductive capacity. Kiss1 neurons are crucial in this process by stimulating GnRH, yet how Kiss1 neurons are regulated remains unknown. Substance P (SP), an important neuropeptide in pain perception, induces gonadotropin release in adult mice in a kisspeptin-dependent manner. Here, we assessed whether SP, through binding to its receptor NK1R (neurokinin 1 receptor), participates in the timing of puberty onset and fertility in the mouse. We observed that 1) selective NK1R agonists induce gonadotropin release in prepubertal females; 2) the expression of Tac1 (encoding SP) and Tacr1 (NK1R) in the arcuate nucleus is maximal before puberty, suggesting increased SP tone; 3) repeated exposure to NK1R agonists prepubertally advances puberty onset; and 4) female Tac1(-/-) mice display delayed puberty; moreover, 5) SP deficiency leads to subfertility in females, showing fewer corpora lutea and antral follicles and leading to decreased litter size. Thus, our findings support a role for SP in the stimulation of gonadotropins before puberty, acting via Kiss1 neurons to stimulate GnRH release, and its involvement in the attainment of full reproductive capabilities in female mice.

UI MeSH Term Description Entries
D010446 Peptide Fragments Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques. Peptide Fragment,Fragment, Peptide,Fragments, Peptide
D011627 Puberty A period in the human life in which the development of the hypothalamic-pituitary-gonadal system takes place and reaches full maturity. The onset of synchronized endocrine events in puberty lead to the capacity for reproduction (FERTILITY), development of secondary SEX CHARACTERISTICS, and other changes seen in ADOLESCENT DEVELOPMENT. Puberties
D005260 Female Females
D005298 Fertility The capacity to conceive or to induce conception. It may refer to either the male or female. Fecundity,Below Replacement Fertility,Differential Fertility,Fecundability,Fertility Determinants,Fertility Incentives,Fertility Preferences,Fertility, Below Replacement,Marital Fertility,Natural Fertility,Subfecundity,World Fertility Survey,Determinant, Fertility,Determinants, Fertility,Fertility Determinant,Fertility Incentive,Fertility Preference,Fertility Survey, World,Fertility Surveys, World,Fertility, Differential,Fertility, Marital,Fertility, Natural,Preference, Fertility,Preferences, Fertility,Survey, World Fertility,Surveys, World Fertility,World Fertility Surveys
D006062 Gonadotropins Hormones that stimulate gonadal functions such as GAMETOGENESIS and sex steroid hormone production in the OVARY and the TESTIS. Major gonadotropins are glycoproteins produced primarily by the adenohypophysis (GONADOTROPINS, PITUITARY) and the placenta (CHORIONIC GONADOTROPIN). In some species, pituitary PROLACTIN and PLACENTAL LACTOGEN exert some luteotropic activities. Gonadotropin
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012741 Sexual Maturation Achievement of full sexual capacity in animals and in humans. Sex Maturation,Maturation, Sex,Maturation, Sexual
D013373 Substance P An eleven-amino acid neurotransmitter that appears in both the central and peripheral nervous systems. It is involved in transmission of PAIN, causes rapid contractions of the gastrointestinal smooth muscle, and modulates inflammatory and immune responses. Euler-Gaddum Substance P,Hypothalamic Substance P,SP(1-11),Euler Gaddum Substance P,Substance P, Euler-Gaddum,Substance P, Hypothalamic
D051379 Mice The common name for the genus Mus. Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus
D018040 Receptors, Neurokinin-1 A class of cell surface receptors for TACHYKININS with a preference for SUBSTANCE P. Neurokinin-1 (NK-1) receptors have been cloned and are members of the G protein coupled receptor superfamily. They are found on many cell types including central and peripheral neurons, smooth muscle cells, acinar cells, endothelial cells, fibroblasts, and immune cells. NK-1 Receptors,Neurokinin-1 Receptors,Receptors, Substance P,SP-P Receptors,Substance P Receptors,NK-1 Receptor,Neurokinin-1 Receptor,Receptors, NK-1,Receptors, SP-P,SP-P Receptor,Substance P Receptor,Substance-P Receptor,Tachykinin Receptor 1,NK 1 Receptor,NK 1 Receptors,Neurokinin 1 Receptor,Neurokinin 1 Receptors,P Receptor, Substance,P Receptors, Substance,Receptor, NK-1,Receptor, Neurokinin-1,Receptor, SP-P,Receptor, Substance P,Receptor, Substance-P,Receptors, NK 1,Receptors, Neurokinin 1,Receptors, SP P,SP P Receptor,SP P Receptors

Related Publications

Serap Simavli, and Iain R Thompson, and Caroline A Maguire, and John C Gill, and Rona S Carroll, and Andrew Wolfe, and Ursula B Kaiser, and Víctor M Navarro
Grid1 regulates the onset of puberty in female rats.
May 2024, The Journal of veterinary medical science,
Serap Simavli, and Iain R Thompson, and Caroline A Maguire, and John C Gill, and Rona S Carroll, and Andrew Wolfe, and Ursula B Kaiser, and Víctor M Navarro
ERα in Tac2 Neurons Regulates Puberty Onset in Female Mice.
April 2016, Endocrinology,
Serap Simavli, and Iain R Thompson, and Caroline A Maguire, and John C Gill, and Rona S Carroll, and Andrew Wolfe, and Ursula B Kaiser, and Víctor M Navarro
Kisspeptin, puberty and female fertility.
May 2007, Reproductive biomedicine online,
Serap Simavli, and Iain R Thompson, and Caroline A Maguire, and John C Gill, and Rona S Carroll, and Andrew Wolfe, and Ursula B Kaiser, and Víctor M Navarro
The Posterodorsal Medial Amygdala Regulates the Timing of Puberty Onset in Female Rats.
October 2015, Endocrinology,
Serap Simavli, and Iain R Thompson, and Caroline A Maguire, and John C Gill, and Rona S Carroll, and Andrew Wolfe, and Ursula B Kaiser, and Víctor M Navarro
[Onset of puberty in the female rat or mouse after hypothalamus implants].
November 1960, Comptes rendus hebdomadaires des seances de l'Academie des sciences,
Serap Simavli, and Iain R Thompson, and Caroline A Maguire, and John C Gill, and Rona S Carroll, and Andrew Wolfe, and Ursula B Kaiser, and Víctor M Navarro
Puberty and the onset of substance use and abuse.
September 2004, Pediatrics,
Serap Simavli, and Iain R Thompson, and Caroline A Maguire, and John C Gill, and Rona S Carroll, and Andrew Wolfe, and Ursula B Kaiser, and Víctor M Navarro
The adrenal rhythm and puberty onset in the female rat.
November 1978, Life sciences,
Serap Simavli, and Iain R Thompson, and Caroline A Maguire, and John C Gill, and Rona S Carroll, and Andrew Wolfe, and Ursula B Kaiser, and Víctor M Navarro
The onset of female puberty: studies in the rat.
January 1986, Recent progress in hormone research,
Serap Simavli, and Iain R Thompson, and Caroline A Maguire, and John C Gill, and Rona S Carroll, and Andrew Wolfe, and Ursula B Kaiser, and Víctor M Navarro
[Comparative study of hypothalamic and pituitary implants in the onset of puberty in the female rat and mouse].
January 1960, Comptes rendus des seances de la Societe de biologie et de ses filiales,
Serap Simavli, and Iain R Thompson, and Caroline A Maguire, and John C Gill, and Rona S Carroll, and Andrew Wolfe, and Ursula B Kaiser, and Víctor M Navarro
Neuroendocrine mechanisms controlling the onset of female puberty.
January 1987, Reproductive toxicology (Elmsford, N.Y.),
Copied contents to your clipboard!