-transparent.png){kind=logo}
Probucol administration of 4 weeks produced torsades de pointes associated with exacerbated QT interval prolongation in a 36-year-old woman with Romano-Ward syndrome. With discontinuance of probucol, the QT interval corrected for rate shortened from 620 msec to 500 msec and ventricular ectopic beats disappeared completely. Although probucol is known to prolong the QT interval, associated ventricular tachyarrhythmia has not been reported in humans as yet. This case suggests that one should be very careful in the administration of probucol to patients with long baseline QT intervals.
Related Publications
H Matsuhashi, and
S Onodera, and
Y Kawamura, and
N Hasebe, and
C Kohmura, and
H Yamashita, and
K Tobise
January 2009,
BMJ case reports,
H Matsuhashi, and
S Onodera, and
Y Kawamura, and
N Hasebe, and
C Kohmura, and
H Yamashita, and
K Tobise
November 2003,
Heart (British Cardiac Society),
H Matsuhashi, and
S Onodera, and
Y Kawamura, and
N Hasebe, and
C Kohmura, and
H Yamashita, and
K Tobise
July 2017,
P & T : a peer-reviewed journal for formulary management,
H Matsuhashi, and
S Onodera, and
Y Kawamura, and
N Hasebe, and
C Kohmura, and
H Yamashita, and
K Tobise
August 2013,
Journal of cardiology cases,
H Matsuhashi, and
S Onodera, and
Y Kawamura, and
N Hasebe, and
C Kohmura, and
H Yamashita, and
K Tobise
October 2011,
Pediatrics international : official journal of the Japan Pediatric Society,
H Matsuhashi, and
S Onodera, and
Y Kawamura, and
N Hasebe, and
C Kohmura, and
H Yamashita, and
K Tobise
May 2016,
The Journal of physiology,
H Matsuhashi, and
S Onodera, and
Y Kawamura, and
N Hasebe, and
C Kohmura, and
H Yamashita, and
K Tobise
April 1999,
Indian journal of psychiatry,
H Matsuhashi, and
S Onodera, and
Y Kawamura, and
N Hasebe, and
C Kohmura, and
H Yamashita, and
K Tobise
March 2019,
Clinical medicine (London, England),
H Matsuhashi, and
S Onodera, and
Y Kawamura, and
N Hasebe, and
C Kohmura, and
H Yamashita, and
K Tobise
April 2007,
British journal of hospital medicine (London, England : 2005),
H Matsuhashi, and
S Onodera, and
Y Kawamura, and
N Hasebe, and
C Kohmura, and
H Yamashita, and
K Tobise
December 2019,
European heart journal. Acute cardiovascular care,
