Pharmaceuticals and other xenobiotic molecules are being increasingly detected in drinking water, food crops, and breast milk. This issue represents a novel toxicological concern, especially for sensitive populations like pregnant women and breastfeeding infants. This commentary calls for more interdisciplinary research efforts focused on elucidating the transfer of contaminants of emerging concern from mother to child, as well as the relevant toxicological impacts on the child. The need for more tangible efforts to reduce pharmaceutical loads in environmental systems is also highlighted.