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Bleeding, obstruction and invagination are the common symptoms of large polyps in the duodenal bulb. We present 2 patients with a large ulcerated Brunner's gland adenoma. The clinical findings were acute bleeding and nonspecific upper gastrointestinal symptoms. The treatment was surgical due to a suspect histological finding in one case, a thick stalk in the other, and the fact that endoscopic polypectomy is a much higher risk procedure in the duodenum than in the colon.
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