Biomaterial Database

Oral consumption of α-linolenic acid increases serum BDNF levels in healthy adult humans. 2015

Mahmoudreza Hadjighassem, and Behnam Kamalidehghan, and Nima Shekarriz, and Argavan Baseerat, and Nima Molavi, and Masoud Mehrpour, and Mohammad Taghi Joghataei, and Mahdi Tondar, and Fatemeh Ahmadipour, and Goh Yong Meng

Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran. mhadjighassem@tums.ac.ir.

OBJECTIVE Dietary omega-6 and omega-3 fatty acids have remarkable impacts on the levels of DHA in the brain and retina. Low levels of DHA in plasma and blood hamper visual and neural development in children and cause dementia and cognitive decline in adults. The level of brain-derived neurotrophic factors (BDNF) changes with dietary omega-3 fatty acid intake. BDNF is known for its effects on promoting neurogenesis and neuronal survival. METHODS In this study, we examined the effect of the oral consumption of α-Linolenic acid (ALA) on blood levels of BDNF and Malondialdehyde (MDA) in healthy adult humans. 30 healthy volunteers, 15 men and 15 women, were selected randomly. Each individual served as his or her own control. Before consuming the Flaxseed oil capsules, 5cc blood from each individual was sampled in order to measure the plasma levels of BDNF and MDA as baseline controls. During the experiment, each individual was given 3 oral capsules of flaxseed oil, containing 500mg of alpha linolenic acid, daily for one week. Then, plasma levels of BDNF and MDA were tested. RESULTS The plasma levels of BDNF and MDA significantly (P < 0.05) increased in individuals who received the oral capsules of ALA. Plasma levels of BDNF increased more in the women in comparison with the men. CONCLUSIONS ALA treatment could be a feasible approach to reduce size of infarcts in stroke patients. Thus, ALA could be used in adjunction with routine stroke therapies to minimize brain lesions caused by stroke.

UI	MeSH Term	Description	Entries
D008043	Linseed Oil	The fixed oil obtained from the dried ripe seed of linseed, Linum usitatissimum (L. Linaceae). It is used as an emollient in liniments, pastes, and medicinal soaps, and in veterinary medicine as a laxative. It is also called flaxseed oil. (Dorland, 28th ed)	Flaxseed Oil,Oil, Flaxseed,Oil, Linseed
D008297	Male		Males
D008315	Malondialdehyde	The dialdehyde of malonic acid.	Malonaldehyde,Propanedial,Malonylaldehyde,Malonyldialdehyde,Sodium Malondialdehyde,Malondialdehyde, Sodium
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000284	Administration, Oral	The giving of drugs, chemicals, or other substances by mouth.	Drug Administration, Oral,Administration, Oral Drug,Oral Administration,Oral Drug Administration,Administrations, Oral,Administrations, Oral Drug,Drug Administrations, Oral,Oral Administrations,Oral Drug Administrations
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D015525	Fatty Acids, Omega-3	A group of unsaturated fatty acids occurring mainly in fish oils, with three double bonds at particular positions in the hydrocarbon chain.	N-3 Fatty Acid,Omega-3 Fatty Acid,Omega-3 Fatty Acids,n-3 Fatty Acids,n-3 Oil,n3 Oil,Omega 3 Fatty Acids,n-3 Oils,n-3 PUFA,n-3 Polyunsaturated Fatty Acid,n3 Fatty Acid,n3 Oils,n3 PUFA,n3 Polyunsaturated Fatty Acid,Acid, N-3 Fatty,Acid, Omega-3 Fatty,Fatty Acid, N-3,Fatty Acid, Omega-3,Fatty Acid, n3,N 3 Fatty Acid,Oil, n-3,Oil, n3,Omega 3 Fatty Acid,PUFA, n-3,PUFA, n3,n 3 Fatty Acids,n 3 Oil,n 3 Oils,n 3 PUFA,n 3 Polyunsaturated Fatty Acid
D017962	alpha-Linolenic Acid	A fatty acid that is found in plants and involved in the formation of prostaglandins.	Linolenic Acid,Linolenate,alpha-Linolenic Acid, (E,E,E)-Isomer,alpha-Linolenic Acid, (E,E,Z)-Isomer,alpha-Linolenic Acid, (E,Z,E)-Isomer,alpha-Linolenic Acid, (E,Z,Z)-Isomer,alpha-Linolenic Acid, (Z,E,E)-Isomer,alpha-Linolenic Acid, (Z,E,Z)-Isomer,alpha-Linolenic Acid, (Z,Z,E)-Isomer,alpha-Linolenic Acid, Ammonium Salt,alpha-Linolenic Acid, Calcium Salt,alpha-Linolenic Acid, Lithium Salt,alpha-Linolenic Acid, Magnesium Salt,alpha-Linolenic Acid, Potassium Salt,alpha-Linolenic Acid, Sodium Salt,alpha-Linolenic Acid, Tin(2+) Salt,alpha-Linolenic Acid, Zinc Salt,alpha Linolenic Acid,alpha Linolenic Acid, Ammonium Salt,alpha Linolenic Acid, Calcium Salt,alpha Linolenic Acid, Lithium Salt,alpha Linolenic Acid, Magnesium Salt,alpha Linolenic Acid, Potassium Salt,alpha Linolenic Acid, Sodium Salt,alpha Linolenic Acid, Zinc Salt
D019208	Brain-Derived Neurotrophic Factor	A member of the nerve growth factor family of trophic factors. In the brain BDNF has a trophic action on retinal, cholinergic, and dopaminergic neurons, and in the peripheral nervous system it acts on both motor and sensory neurons. (From Kendrew, The Encyclopedia of Molecular Biology, 1994)	BDNF,Brain Derived Neurotrophic Factor,Factor, Brain-Derived Neurotrophic,Neurotrophic Factor, Brain-Derived