Selaginellin and biflavonoids as protein tyrosine phosphatase 1B inhibitors from Selaginella tamariscina and their glucose uptake stimulatory effects. 2015

Phi-Hung Nguyen, and Da-Jung Ji, and Yu-Ran Han, and Jae-Sue Choi, and Dong-Young Rhyu, and Byung-Sun Min, and Mi-Hee Woo
College of Pharmacy, Drug Research and Development Center, Catholic University of Daegu, Gyeongsan 712-702, Republic of Korea; Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Hanoi, Viet Nam.

As part of an ongoing search for new antidiabetic agents from medicinal plants, the methanol extract of the aerial parts of Selaginella tamariscina was found to possess stimulatory effect on glucose uptake in 3T3-L1 adipocyte cells. Thus, bioassay-guided isolation of this active extract yielded two new compounds (1 and 2) along with five known biflavonoids (3-7). Their structures were elucidated by extensive analysis of spectroscopic and physicochemical data. The absolute configuration of compound 2 was determined by specific rotation and CD data analysis. All isolates exhibited potent inhibitory effects on PTP1B enzyme with IC50 values ranging from 4.5±0.1 to 13.2±0.8μM. Furthermore, the isolates (1-7) showed significant stimulatory effects on 2-NBDG uptake in 3T3-L1 adipocyte cells. Of these, compounds (1, 6, and 7) which exhibited mixed-competitive inhibition modes against PTP1B, showed potent stimulatory effects on 2-NBDG uptake. This result indicated the potential of these biflavonoids as lead molecules for development of antidiabetic agents and the beneficial use of S. tamariscina against hyperglycemia.

UI MeSH Term Description Entries
D007004 Hypoglycemic Agents Substances which lower blood glucose levels. Antidiabetic,Antidiabetic Agent,Antidiabetic Drug,Antidiabetics,Antihyperglycemic,Antihyperglycemic Agent,Hypoglycemic,Hypoglycemic Agent,Hypoglycemic Drug,Antidiabetic Agents,Antidiabetic Drugs,Antihyperglycemic Agents,Antihyperglycemics,Hypoglycemic Drugs,Hypoglycemic Effect,Hypoglycemic Effects,Hypoglycemics,Agent, Antidiabetic,Agent, Antihyperglycemic,Agent, Hypoglycemic,Agents, Antidiabetic,Agents, Antihyperglycemic,Agents, Hypoglycemic,Drug, Antidiabetic,Drug, Hypoglycemic,Drugs, Antidiabetic,Drugs, Hypoglycemic,Effect, Hypoglycemic,Effects, Hypoglycemic
D009327 4-Chloro-7-nitrobenzofurazan A benzofuran derivative used as a protein reagent since the terminal N-NBD-protein conjugate possesses interesting fluorescence and spectral properties. It has also been used as a covalent inhibitor of both beef heart mitochondrial ATPase and bacterial ATPase. Chloronitrobenzoxadiazole,NBD Chloride,7-Chloro-4-nitrobenzofurazan,NBF-Cl,Nitrobenzoxadiazole Chloride,4 Chloro 7 nitrobenzofurazan,7 Chloro 4 nitrobenzofurazan,Chloride, NBD,Chloride, Nitrobenzoxadiazole,NBF Cl
D010936 Plant Extracts Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard. Herbal Medicines,Plant Extract,Extract, Plant,Extracts, Plant,Medicines, Herbal
D010946 Plants, Medicinal Plants whose roots, leaves, seeds, bark, or other constituent parts possess therapeutic, tonic, purgative, curative or other pharmacologic attributes, when administered to man or animals. Herbs, Medicinal,Medicinal Herbs,Healing Plants,Medicinal Plants,Pharmaceutical Plants,Healing Plant,Herb, Medicinal,Medicinal Herb,Medicinal Plant,Pharmaceutical Plant,Plant, Healing,Plant, Medicinal,Plant, Pharmaceutical,Plants, Healing,Plants, Pharmaceutical
D002470 Cell Survival The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability. Cell Viability,Cell Viabilities,Survival, Cell,Viabilities, Cell,Viability, Cell
D003512 Cyclohexanones Cyclohexane ring substituted by one or more ketones in any position.
D003847 Deoxyglucose 2-Deoxy-D-arabino-hexose. An antimetabolite of glucose with antiviral activity. 2-Deoxy-D-glucose,2-Deoxyglucose,2-Desoxy-D-glucose,2 Deoxy D glucose,2 Deoxyglucose,2 Desoxy D glucose
D005947 Glucose A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement. Dextrose,Anhydrous Dextrose,D-Glucose,Glucose Monohydrate,Glucose, (DL)-Isomer,Glucose, (alpha-D)-Isomer,Glucose, (beta-D)-Isomer,D Glucose,Dextrose, Anhydrous,Monohydrate, Glucose
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000432 Methanol A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness. Alcohol, Methyl,Carbinol,Sodium Methoxide,Wood Alcohol,Alcohol, Wood,Methoxide, Sodium,Methyl Alcohol

Related Publications

Phi-Hung Nguyen, and Da-Jung Ji, and Yu-Ran Han, and Jae-Sue Choi, and Dong-Young Rhyu, and Byung-Sun Min, and Mi-Hee Woo
September 2019, Fitoterapia,
Phi-Hung Nguyen, and Da-Jung Ji, and Yu-Ran Han, and Jae-Sue Choi, and Dong-Young Rhyu, and Byung-Sun Min, and Mi-Hee Woo
March 2012, Planta medica,
Phi-Hung Nguyen, and Da-Jung Ji, and Yu-Ran Han, and Jae-Sue Choi, and Dong-Young Rhyu, and Byung-Sun Min, and Mi-Hee Woo
January 2015, Journal of Asian natural products research,
Phi-Hung Nguyen, and Da-Jung Ji, and Yu-Ran Han, and Jae-Sue Choi, and Dong-Young Rhyu, and Byung-Sun Min, and Mi-Hee Woo
January 2015, Journal of natural products,
Phi-Hung Nguyen, and Da-Jung Ji, and Yu-Ran Han, and Jae-Sue Choi, and Dong-Young Rhyu, and Byung-Sun Min, and Mi-Hee Woo
March 2021, Journal of natural products,
Phi-Hung Nguyen, and Da-Jung Ji, and Yu-Ran Han, and Jae-Sue Choi, and Dong-Young Rhyu, and Byung-Sun Min, and Mi-Hee Woo
April 2011, Journal of Asian natural products research,
Phi-Hung Nguyen, and Da-Jung Ji, and Yu-Ran Han, and Jae-Sue Choi, and Dong-Young Rhyu, and Byung-Sun Min, and Mi-Hee Woo
December 2015, Molecules (Basel, Switzerland),
Phi-Hung Nguyen, and Da-Jung Ji, and Yu-Ran Han, and Jae-Sue Choi, and Dong-Young Rhyu, and Byung-Sun Min, and Mi-Hee Woo
July 2008, Chemical & pharmaceutical bulletin,
Phi-Hung Nguyen, and Da-Jung Ji, and Yu-Ran Han, and Jae-Sue Choi, and Dong-Young Rhyu, and Byung-Sun Min, and Mi-Hee Woo
January 2024, Phytochemistry,
Phi-Hung Nguyen, and Da-Jung Ji, and Yu-Ran Han, and Jae-Sue Choi, and Dong-Young Rhyu, and Byung-Sun Min, and Mi-Hee Woo
July 2019, Journal of natural products,
Copied contents to your clipboard!