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In vivo effects of prostaglandin D2 (PGD2) on rat testicular testosterone levels were studied. Testosterone levels were determined by HPLC after 6 hours of PGD2 and of hCG. The testosterone levels were decreased by dose of 500 micrograms/rat intraperitoneal injection. Testis testosterone levels were subsequently decreased by intratesticular injection with PGD2 (1.0 micrograms) into the right testis. The left testis received vehicle alone for control. The increase in testosterone levels induced by hCG (50, 100 and 500 unit/rat s.c.) were also inhibited by intraperitoneal injection of 500 micrograms of PGD2. On the other hand, intratesticular injection of hCG (0.01, 0.1 and 1.0 unit/testis) caused an increase in testosterone levels according to dose of hCG. The increase in testosterone levels by hCG was inhibited by simultaneous injection of PGD2 (1.0 micrograms/testis). These results suggest that PGD2 may play an inhibitory action on LH action in androgen synthesis in the rat testis.
K Yamada
October 1988,
The Journal of endocrinology,
K Yamada
March 1977,
Endocrinology,
K Yamada
January 1986,
Psychopharmacology,
K Yamada
March 1985,
Asia-Oceania journal of obstetrics and gynaecology,
K Yamada
January 2017,
Biochemical and biophysical research communications,
K Yamada
July 1981,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
K Yamada
September 1984,
Prostaglandins, leukotrienes, and medicine,
K Yamada
August 1988,
Prostaglandins, leukotrienes, and essential fatty acids,
K Yamada
January 1983,
Fertility and sterility,
K Yamada
January 1980,
Postepy higieny i medycyny doswiadczalnej,
