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Copper-zinc, cyanide-sensitive superoxide dismutase (Cu-Zn-SOD) was detected in homogenates of Moniezia expansa. The enzyme was purified by a sequence of multiple differential centrifugations, ammonium sulphate precipitation, ion-exchange and G-75 Sephadex column chromatography. The final enzyme preparation had a specific activity of 623.00 +/- 9.97U per mg protein and, after isolation, a single-staining band on acrylamide-SDS gels was detected which coincided with enzyme activity. The inhibitory activities of several benzimidazoles and several novel pyrimidine derivatives were determined on purified extracts of the M. expansa Cu-Zn-SOD. The results indicated that the percentage inhibition of Cu-Zn-SOD by some pyrimidine derivatives (6-amino-1, 3-dimethyl-5-nitroso-uracil, 6-amino-5-methyl-5-nitroso-uracil and 5-amino-uracil) was markedly higher than inhibition with the benzimidazoles.
M Sanchez-Moreno, and
J E Ortega, and
A Sanchez-Navas, and
J M Salas-Peregrin, and
M Monteoliva
December 1977,
Biochemical and biophysical research communications,
M Sanchez-Moreno, and
J E Ortega, and
A Sanchez-Navas, and
J M Salas-Peregrin, and
M Monteoliva
September 2007,
Free radical biology & medicine,
M Sanchez-Moreno, and
J E Ortega, and
A Sanchez-Navas, and
J M Salas-Peregrin, and
M Monteoliva
February 1997,
Molecules and cells,
M Sanchez-Moreno, and
J E Ortega, and
A Sanchez-Navas, and
J M Salas-Peregrin, and
M Monteoliva
April 1998,
Age,
M Sanchez-Moreno, and
J E Ortega, and
A Sanchez-Navas, and
J M Salas-Peregrin, and
M Monteoliva
September 2002,
Biochemical and biophysical research communications,
M Sanchez-Moreno, and
J E Ortega, and
A Sanchez-Navas, and
J M Salas-Peregrin, and
M Monteoliva
January 1992,
Memorias do Instituto Oswaldo Cruz,
M Sanchez-Moreno, and
J E Ortega, and
A Sanchez-Navas, and
J M Salas-Peregrin, and
M Monteoliva
September 2010,
The Journal of biological chemistry,
M Sanchez-Moreno, and
J E Ortega, and
A Sanchez-Navas, and
J M Salas-Peregrin, and
M Monteoliva
October 1996,
Archives of biochemistry and biophysics,
M Sanchez-Moreno, and
J E Ortega, and
A Sanchez-Navas, and
J M Salas-Peregrin, and
M Monteoliva
October 2006,
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry,
M Sanchez-Moreno, and
J E Ortega, and
A Sanchez-Navas, and
J M Salas-Peregrin, and
M Monteoliva
April 1992,
Clinical biochemistry,
