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The neuronal and smooth muscle effects of a methanol extract prepared from the air-dried flowering aerial parts of Sideritis montana L. (SME) was tested in vitro on Guinea-pig ileum. The chemical composition of the investigated extract was analysed by HPLC-MS, and chrysoeriol, chlorogenic acid and caffeic acid were detected as main constituents. The isolated organ assay showed that S. montana extract caused an immediate contraction and a more slowly developing inhibitory response in the ileum. The SME-induced contractions were strongly inhibited by the acetylcholine muscarinic receptor antagonist atropine (0.5 μM), but not by either the Na+ channel blocker tetrodotoxin (TTX; 0.5 μM) or the histamine H1 receptor antagonist chloropyramine (0.5 μM). Selective desensitization of capsaicin-sensitive neurons by the sensory neuron stimulant and blocker capsaicin did not influence the contractile effect of SME. As to the spasmolytic effect, SME inhibited the effects of electrical field stimulation, exogenous acetylcholine, and histamine. These smooth muscle-relaxing effects were reversible in 40 min by repeated renewals of the bathing solution.
Barbara Tóth, and
Loránd Bartho, and
Andrea Vasas, and
Zsolt Sándor, and
Nikoletta Jedlinszki, and
Gyula Pinke, and
Judit Hohmann
April 1981,
Japanese journal of pharmacology,
Barbara Tóth, and
Loránd Bartho, and
Andrea Vasas, and
Zsolt Sándor, and
Nikoletta Jedlinszki, and
Gyula Pinke, and
Judit Hohmann
May 1981,
Agents and actions,
Barbara Tóth, and
Loránd Bartho, and
Andrea Vasas, and
Zsolt Sándor, and
Nikoletta Jedlinszki, and
Gyula Pinke, and
Judit Hohmann
January 1988,
General pharmacology,
Barbara Tóth, and
Loránd Bartho, and
Andrea Vasas, and
Zsolt Sándor, and
Nikoletta Jedlinszki, and
Gyula Pinke, and
Judit Hohmann
August 1968,
Archives internationales de pharmacodynamie et de therapie,
Barbara Tóth, and
Loránd Bartho, and
Andrea Vasas, and
Zsolt Sándor, and
Nikoletta Jedlinszki, and
Gyula Pinke, and
Judit Hohmann
July 1973,
Archives internationales de pharmacodynamie et de therapie,
Barbara Tóth, and
Loránd Bartho, and
Andrea Vasas, and
Zsolt Sándor, and
Nikoletta Jedlinszki, and
Gyula Pinke, and
Judit Hohmann
January 1968,
Pharmacology,
Barbara Tóth, and
Loránd Bartho, and
Andrea Vasas, and
Zsolt Sándor, and
Nikoletta Jedlinszki, and
Gyula Pinke, and
Judit Hohmann
March 2004,
Inflammation research : official journal of the European Histamine Research Society ... [et al.],
Barbara Tóth, and
Loránd Bartho, and
Andrea Vasas, and
Zsolt Sándor, and
Nikoletta Jedlinszki, and
Gyula Pinke, and
Judit Hohmann
May 1986,
The Journal of physiology,
Barbara Tóth, and
Loránd Bartho, and
Andrea Vasas, and
Zsolt Sándor, and
Nikoletta Jedlinszki, and
Gyula Pinke, and
Judit Hohmann
October 2010,
Journal of medicinal food,
Barbara Tóth, and
Loránd Bartho, and
Andrea Vasas, and
Zsolt Sándor, and
Nikoletta Jedlinszki, and
Gyula Pinke, and
Judit Hohmann
May 1983,
Journal of pharmacobio-dynamics,
