Biomaterial Database

Inhibition of the vagal reflex-induced tracheal constriction by psychotropic drugs. 1989

Y Tsuchiya, and T Hosokawa, and Y Kasuya

Department of Pharmacology, School of Pharmacy, Hoshi University, Tokyo, Japan.

We investigated the effects of psychotropic drugs on reflex tracheal constriction in anesthetized, paralyzed, and artificially ventilated mongrel dogs. The tracheal constriction induced by the electrical stimulation of the central cut end of the right vagus nerve was abolished by sectioning both the left superior laryngeal and recurrent laryngeal nerves, and was reduced by a low dose of pentobarbital (3 mg/kg, i.v.). This indicates that the tracheal constriction is mediated by a vagal reflex. Chlorpromazine (3 mg/kg, i.v.) and imipramine (1-3 mg/kg) reduced the reflex tracheal constriction. Chlorpromazine and imipramine had no effect on the tracheal constriction induced by the efferent electrical stimulation of the recurrent laryngeal nerve. This suggests that the higher centers may affect the reflex airway constriction and that the present preparation may be useful for investigating the effect of psychotropic drugs on the reflex airway constriction during asthmatic attacks.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D010424	Pentobarbital	A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)	Mebubarbital,Mebumal,Diabutal,Etaminal,Ethaminal,Nembutal,Pentobarbital Sodium,Pentobarbital, Monosodium Salt,Pentobarbitone,Sagatal,Monosodium Salt Pentobarbital
D011619	Psychotropic Drugs	A loosely defined grouping of drugs that have effects on psychological function. Here the psychotropic agents include the antidepressive agents, hallucinogens, and tranquilizing agents (including the antipsychotics and anti-anxiety agents).	Psychoactive Agent,Psychoactive Agents,Psychoactive Drug,Psychopharmaceutical,Psychopharmaceuticals,Psychotropic Drug,Psychoactive Drugs,Agent, Psychoactive,Agents, Psychoactive,Drug, Psychoactive,Drug, Psychotropic,Drugs, Psychoactive,Drugs, Psychotropic
D012018	Reflex	An involuntary movement or exercise of function in a part, excited in response to a stimulus applied to the periphery and transmitted to the brain or spinal cord.
D004285	Dogs	The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)	Canis familiaris,Dog
D000403	Airway Resistance	Physiologically, the opposition to flow of air caused by the forces of friction. As a part of pulmonary function testing, it is the ratio of driving pressure to the rate of air flow.	Airway Resistances,Resistance, Airway,Resistances, Airway
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D014132	Trachea	The cartilaginous and membranous tube descending from the larynx and branching into the right and left main bronchi.	Tracheas
D014135	Tracheal Stenosis	A pathological narrowing of the TRACHEA.	Stenoses, Tracheal,Stenosis, Tracheal,Tracheal Stenoses
D014630	Vagus Nerve	The 10th cranial nerve. The vagus is a mixed nerve which contains somatic afferents (from skin in back of the ear and the external auditory meatus), visceral afferents (from the pharynx, larynx, thorax, and abdomen), parasympathetic efferents (to the thorax and abdomen), and efferents to striated muscle (of the larynx and pharynx).	Cranial Nerve X,Pneumogastric Nerve,Tenth Cranial Nerve,Nerve X,Nervus Vagus,Cranial Nerve, Tenth,Cranial Nerves, Tenth,Nerve X, Cranial,Nerve Xs,Nerve, Pneumogastric,Nerve, Tenth Cranial,Nerve, Vagus,Nerves, Pneumogastric,Nerves, Tenth Cranial,Nerves, Vagus,Pneumogastric Nerves,Tenth Cranial Nerves,Vagus Nerves,Vagus, Nervus