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Deprivation of pups from mother and sibs for 3 min daily from day 5 to day 41 of life reduced activities of 4 hepatic mixed function oxidases (MFO) expressed per mg protein in male rats compared to unhandled control rats. These decreases, though generally small, 22.4% and under, reached statistical significance for the substrates aminopyrine, benzphetamine and ethoxycoumarin. This handling procedure did not consistently affect the inductive response to phenobarbital. Previously ignored as a source of variability in response to xenobiotics, "handling" appears from these results to merit further investigation as such a factor in uninduced rats. Differences among rats in "handling" could contribute to large day-to-day variations in their metabolism of xenobiotics.
E S Vesell, and
F Heubel, and
K J Netter
October 1984,
Xenobiotica; the fate of foreign compounds in biological systems,
E S Vesell, and
F Heubel, and
K J Netter
August 1989,
Japanese journal of pharmacology,
E S Vesell, and
F Heubel, and
K J Netter
January 1978,
Journal of environmental pathology and toxicology,
E S Vesell, and
F Heubel, and
K J Netter
May 1970,
Science (New York, N.Y.),
E S Vesell, and
F Heubel, and
K J Netter
January 1981,
General pharmacology,
E S Vesell, and
F Heubel, and
K J Netter
February 1980,
Biochimica et biophysica acta,
E S Vesell, and
F Heubel, and
K J Netter
August 1982,
Research communications in chemical pathology and pharmacology,
E S Vesell, and
F Heubel, and
K J Netter
January 1981,
Pharmacology,
E S Vesell, and
F Heubel, and
K J Netter
April 1977,
Indian journal of experimental biology,
E S Vesell, and
F Heubel, and
K J Netter
May 1984,
Bulletin of environmental contamination and toxicology,
