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Response to letter regarding article, "Proprotein convertase subtilisin kexin type 9 promotes intestinal overproduction of triglyceride-rich apolipoprotein B lipoproteins through both low-density lipoprotein receptor-dependent and -independent mechanisms". 2015

Shirya Rashid, and Hagai Tavori, and Patrick E Brown, and MacRae F Linton, and Jane He, and Ilaria Giunzioni, and Sergio Fazio
Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, and Saint John, New Brunswick, Canada.

UI MeSH Term Description Entries
D011973 Receptors, LDL Receptors on the plasma membrane of nonhepatic cells that specifically bind LDL. The receptors are localized in specialized regions called coated pits. Hypercholesteremia is caused by an allelic genetic defect of three types: 1, receptors do not bind to LDL; 2, there is reduced binding of LDL; and 3, there is normal binding but no internalization of LDL. In consequence, entry of cholesterol esters into the cell is impaired and the intracellular feedback by cholesterol on 3-hydroxy-3-methylglutaryl CoA reductase is lacking. LDL Receptors,Lipoprotein LDL Receptors,Receptors, Low Density Lipoprotein,LDL Receptor,LDL Receptors, Lipoprotein,Low Density Lipoprotein Receptor,Low Density Lipoprotein Receptors,Receptors, Lipoprotein, LDL,Receptor, LDL,Receptors, Lipoprotein LDL
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001055 Apolipoproteins B Major structural proteins of triacylglycerol-rich LIPOPROTEINS. There are two forms, apolipoprotein B-100 and apolipoprotein B-48, both derived from a single gene. ApoB-100 expressed in the liver is found in low-density lipoproteins (LIPOPROTEINS, LDL; LIPOPROTEINS, VLDL). ApoB-48 expressed in the intestine is found in CHYLOMICRONS. They are important in the biosynthesis, transport, and metabolism of triacylglycerol-rich lipoproteins. Plasma Apo-B levels are high in atherosclerotic patients but non-detectable in ABETALIPOPROTEINEMIA. Apo-B,Apo B,ApoB,Apoprotein (B),Apoproteins B
D012697 Serine Endopeptidases Any member of the group of ENDOPEPTIDASES containing at the active site a serine residue involved in catalysis. Serine Endopeptidase,Endopeptidase, Serine,Endopeptidases, Serine
D014280 Triglycerides An ester formed from GLYCEROL and three fatty acid groups. Triacylglycerol,Triacylglycerols,Triglyceride
D015228 Hypertriglyceridemia A condition of elevated levels of TRIGLYCERIDES in the blood. Hypertriglyceridemias
D043484 Proprotein Convertases Proteolytic enzymes that are involved in the conversion of protein precursors such as peptide prohormones into PEPTIDE HORMONES. Some are ENDOPEPTIDASES, some are EXOPEPTIDASES. Pro-Opiomelanocortin Converting Enzyme,Prohormone Convertases,Proprotein Convertase,POMC Convertase,POMC Enzyme,POMC-Converting Enzyme,Pro-Opiocortin Converting Enzyme,Pro-Opiocortin Converting Protease,Prohormone Convertase,Proopiomelanocortin Convertase,Proprotein Convertase, Subtilisin-Kexin Family,Proprotein Convertases, Subtilisin-Kexin Family,Subtilisin-Like Proprotein Convertases,Convertase, POMC,Convertase, Prohormone,Convertase, Proopiomelanocortin,Convertase, Proprotein,Convertases, Prohormone,Convertases, Proprotein,Convertases, Subtilisin-Like Proprotein,Converting Enzyme, Pro-Opiocortin,Converting Enzyme, Pro-Opiomelanocortin,Converting Protease, Pro-Opiocortin,POMC Converting Enzyme,Pro Opiocortin Converting Enzyme,Pro Opiocortin Converting Protease,Pro Opiomelanocortin Converting Enzyme,Proprotein Convertase, Subtilisin Kexin Family,Proprotein Convertases, Subtilisin Kexin Family,Proprotein Convertases, Subtilisin-Like,Subtilisin Like Proprotein Convertases
D020895 Enterocytes Absorptive cells in the lining of the INTESTINAL MUCOSA. They are differentiated EPITHELIAL CELLS with apical MICROVILLI facing the intestinal lumen. Enterocytes are more abundant in the SMALL INTESTINE than in the LARGE INTESTINE. Their microvilli greatly increase the luminal surface area of the cell by 14- to 40 fold. Enterocyte

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