BIOMAT Database Logo BIOMAT Database Logo

Nanodiamonds protect skin from ultraviolet B-induced damage in mice. 2015

Meng-Si Wu, and Der-Shan Sun, and Yu-Chung Lin, and Chia-Liang Cheng, and Shih-Che Hung, and Po-Kong Chen, and Jen-Hung Yang, and Hsin-Hou Chang
Division of Plastic Surgery, Department of Surgery, Buddhist Tzu Chi General Hospital, No. 707 Sec. 3, Chung-Yang Rd, Hualien City, Hualien County, 970, Taiwan. wmnsi@hotmail.com.

BACKGROUND Solar ultraviolet (UV) radiation causes various deleterious effects, and UV blockage is recommended for avoiding sunburn. Nanosized titanium dioxide and zinc oxide offer effective protection and enhance cosmetic appearance but entail health concerns regarding their photocatalytic activity, which generates reactive oxygen species. These concerns are absent in nanodiamonds (NDs). Among the UV wavelengths in sunlight, UVB irradiation primarily threatens human health. RESULTS The efficacy and safety of NDs in UVB protection were evaluated using cell cultures and mouse models. We determined that 2 mg/cm(2) of NDs efficiently reduced over 95% of UVB radiation. Direct UVB exposure caused cell death of cultured keratinocyte, fibroblasts and skin damage in mice. By contrast, ND-shielding significantly protected the aforementioned pathogenic alterations in both cell cultures and mouse models. CONCLUSIONS NDs are feasible and safe materials for preventing UVB-induced skin damage.

UI MeSH Term Description Entries
D006965 Hyperplasia An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells. Hyperplasias
D007962 Leukocytes White blood cells. These include granular leukocytes (BASOPHILS; EOSINOPHILS; and NEUTROPHILS) as well as non-granular leukocytes (LYMPHOCYTES and MONOCYTES). Blood Cells, White,Blood Corpuscles, White,White Blood Cells,White Blood Corpuscles,Blood Cell, White,Blood Corpuscle, White,Corpuscle, White Blood,Corpuscles, White Blood,Leukocyte,White Blood Cell,White Blood Corpuscle
D008297 Male Males
D008810 Mice, Inbred C57BL One of the first INBRED MOUSE STRAINS to be sequenced. This strain is commonly used as genetic background for transgenic mouse models. Refractory to many tumors, this strain is also preferred model for studying role of genetic variations in development of diseases. Mice, C57BL,Mouse, C57BL,Mouse, Inbred C57BL,C57BL Mice,C57BL Mice, Inbred,C57BL Mouse,C57BL Mouse, Inbred,Inbred C57BL Mice,Inbred C57BL Mouse
D011837 Radiation-Protective Agents Drugs used to protect against ionizing radiation. They are usually of interest for use in radiation therapy but have been considered for other purposes, e.g. military. Radiation Protectant,Radiation Protective Agent,Radiation-Protective Agent,Radiation-Protective Drug,Radioprotective Agent,Radioprotective Agents,Radioprotective Drug,Agents, Radiation-Protective,Radiation Protectants,Radiation Protective Agents,Radiation-Protective Drugs,Radiation-Protective Effect,Radiation-Protective Effects,Radioprotective Drugs,Agent, Radiation Protective,Agent, Radiation-Protective,Agent, Radioprotective,Agents, Radiation Protective,Agents, Radioprotective,Drug, Radiation-Protective,Drug, Radioprotective,Drugs, Radiation-Protective,Drugs, Radioprotective,Effect, Radiation-Protective,Effects, Radiation-Protective,Protectant, Radiation,Protectants, Radiation,Protective Agent, Radiation,Protective Agents, Radiation,Radiation Protective Drug,Radiation Protective Drugs,Radiation Protective Effect,Radiation Protective Effects
D011855 Radiodermatitis A cutaneous inflammatory reaction occurring as a result of exposure to ionizing radiation. Dermatitis, Radiation-Induced,Radiation Recall Dermatitis,Radiation-Induced Dermatitis,Radiation Recall Reaction,Dermatitides, Radiation Recall,Dermatitides, Radiation-Induced,Dermatitis, Radiation Induced,Dermatitis, Radiation Recall,Radiation Induced Dermatitis,Radiation Recall Dermatitides,Radiation Recall Reactions,Radiation-Induced Dermatitides,Radiodermatitides,Reaction, Radiation Recall,Reactions, Radiation Recall,Recall Reaction, Radiation,Recall Reactions, Radiation
D002478 Cells, Cultured Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others. Cultured Cells,Cell, Cultured,Cultured Cell
D003872 Dermatitis Any inflammation of the skin. Dermatitides
D005347 Fibroblasts Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules. Fibroblast
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

Meng-Si Wu, and Der-Shan Sun, and Yu-Chung Lin, and Chia-Liang Cheng, and Shih-Che Hung, and Po-Kong Chen, and Jen-Hung Yang, and Hsin-Hou Chang
Silver Nanoparticles Protect Skin from Ultraviolet B-Induced Damage in Mice.
September 2020, International journal of molecular sciences,
Meng-Si Wu, and Der-Shan Sun, and Yu-Chung Lin, and Chia-Liang Cheng, and Shih-Che Hung, and Po-Kong Chen, and Jen-Hung Yang, and Hsin-Hou Chang
Nanodisks protect amphotericin B from ultraviolet light and oxidation-induced damage.
June 2009, Pest management science,
Meng-Si Wu, and Der-Shan Sun, and Yu-Chung Lin, and Chia-Liang Cheng, and Shih-Che Hung, and Po-Kong Chen, and Jen-Hung Yang, and Hsin-Hou Chang
Epigallocatechin gallate eye drops protect against ultraviolet B-induced corneal oxidative damage in mice.
January 2014, Molecular vision,
Meng-Si Wu, and Der-Shan Sun, and Yu-Chung Lin, and Chia-Liang Cheng, and Shih-Che Hung, and Po-Kong Chen, and Jen-Hung Yang, and Hsin-Hou Chang
Tannins protect against skin tumor promotion induced by ultraviolet-B radiation in hairless mice.
January 2000, Nutrition and cancer,
Meng-Si Wu, and Der-Shan Sun, and Yu-Chung Lin, and Chia-Liang Cheng, and Shih-Che Hung, and Po-Kong Chen, and Jen-Hung Yang, and Hsin-Hou Chang
Skin component may protect fishes from ultraviolet-B radiation.
July 1995, Environmental science and pollution research international,
Meng-Si Wu, and Der-Shan Sun, and Yu-Chung Lin, and Chia-Liang Cheng, and Shih-Che Hung, and Po-Kong Chen, and Jen-Hung Yang, and Hsin-Hou Chang
Ability of PABA to protect mammalian skin from ultraviolet light-induced skin tumors and actinic damage.
December 1975, The Journal of investigative dermatology,
Meng-Si Wu, and Der-Shan Sun, and Yu-Chung Lin, and Chia-Liang Cheng, and Shih-Che Hung, and Po-Kong Chen, and Jen-Hung Yang, and Hsin-Hou Chang
Need for a well-balanced sunscreen to protect human skin from both Ultraviolet A and Ultraviolet B damage.
June 2012, Indian journal of dermatology, venereology and leprology,
Meng-Si Wu, and Der-Shan Sun, and Yu-Chung Lin, and Chia-Liang Cheng, and Shih-Che Hung, and Po-Kong Chen, and Jen-Hung Yang, and Hsin-Hou Chang
Monoterpenoid aryl hydrocarbon receptor allosteric antagonists protect against ultraviolet skin damage in female mice.
May 2023, Nature communications,
Meng-Si Wu, and Der-Shan Sun, and Yu-Chung Lin, and Chia-Liang Cheng, and Shih-Che Hung, and Po-Kong Chen, and Jen-Hung Yang, and Hsin-Hou Chang
Effects of Porcine Placenta Extract Ingestion on Ultraviolet B-induced Skin Damage in Hairless Mice.
January 2015, Korean journal for food science of animal resources,
Meng-Si Wu, and Der-Shan Sun, and Yu-Chung Lin, and Chia-Liang Cheng, and Shih-Che Hung, and Po-Kong Chen, and Jen-Hung Yang, and Hsin-Hou Chang
Carboxyfullerenes protect human keratinocytes from ultraviolet-B-induced apoptosis.
November 2000, The Journal of investigative dermatology,
Copied contents to your clipboard!