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Mepirizole (60 and 200 mg/kg, s. c.) and cysteamine (100 and 300 mg/kg, s. c.) markedly inhibited gastric motility in fasted rats. The inhibition caused with the low dose (non-ulcerogenic) of each agent reverted to control levels within 6 h. With high doses (ulcerogenic), however, the inhibition persisted for more than 9 h, and returned to control levels 12 h later. Gastric emptying of liquids was significantly delayed with ulcerogenic and non-ulcerogenic doses of the agents. Delayed emptying (gastric contents) persisted for 12 h with ulcerogenic doses, The pathogenetic relevance of this prolonged inhibition of gastric motility and emptying to ulcerogenecity was considered.
H Tanaka, and
K Takeuchi, and
S Okabe
April 1989,
Digestive diseases and sciences,
H Tanaka, and
K Takeuchi, and
S Okabe
November 1977,
Gastroenterology,
H Tanaka, and
K Takeuchi, and
S Okabe
April 1985,
Gastroenterology,
H Tanaka, and
K Takeuchi, and
S Okabe
August 1988,
Digestive diseases and sciences,
H Tanaka, and
K Takeuchi, and
S Okabe
January 1990,
Digestion,
H Tanaka, and
K Takeuchi, and
S Okabe
August 1983,
Digestive diseases and sciences,
H Tanaka, and
K Takeuchi, and
S Okabe
September 1993,
The American journal of physiology,
H Tanaka, and
K Takeuchi, and
S Okabe
December 1977,
Gastroenterology,
H Tanaka, and
K Takeuchi, and
S Okabe
January 1988,
Toxicologic pathology,
H Tanaka, and
K Takeuchi, and
S Okabe
January 1991,
Scandinavian journal of gastroenterology,
