BIOMAT Database Logo BIOMAT Database Logo

Improved method for synthesis of cysteine modified hyaluronic acid for in situ hydrogel formation. 2015

Xin Zhang, and Pengcheng Sun, and Lingzi Huangshan, and Bi-Huang Hu, and Phillip B Messersmith
Key Laboratory of Tropical Biological Resources of Ministry of Education, College of Oceanography, Hainan University, Haikou, Hainan Province 570228, China. bhhu@hainu.edu.cn.

We developed a new strategy for the functionalization of hyaluronic acid by chemical modification of its C-6 hydroxyl groups through an ether bond to obtain a cysteine-hyaluronic acid conjugate. This conjugate is suitable to prepare injectable and in situ formed hydrogels cross-linked by native chemical ligation and Michael addition under mild conditions.

UI MeSH Term Description Entries
D003432 Cross-Linking Reagents Reagents with two reactive groups, usually at opposite ends of the molecule, that are capable of reacting with and thereby forming bridges between side chains of amino acids in proteins; the locations of naturally reactive areas within proteins can thereby be identified; may also be used for other macromolecules, like glycoproteins, nucleic acids, or other. Bifunctional Reagent,Bifunctional Reagents,Cross Linking Reagent,Crosslinking Reagent,Cross Linking Reagents,Crosslinking Reagents,Linking Reagent, Cross,Linking Reagents, Cross,Reagent, Bifunctional,Reagent, Cross Linking,Reagent, Crosslinking,Reagents, Bifunctional,Reagents, Cross Linking,Reagents, Cross-Linking,Reagents, Crosslinking
D003545 Cysteine A thiol-containing non-essential amino acid that is oxidized to form CYSTINE. Cysteine Hydrochloride,Half-Cystine,L-Cysteine,Zinc Cysteinate,Half Cystine,L Cysteine
D006820 Hyaluronic Acid A natural high-viscosity mucopolysaccharide with alternating beta (1-3) glucuronide and beta (1-4) glucosaminidic bonds. It is found in the UMBILICAL CORD, in VITREOUS BODY and in SYNOVIAL FLUID. A high urinary level is found in PROGERIA. Amo Vitrax,Amvisc,Biolon,Etamucine,Healon,Hyaluronan,Hyaluronate Sodium,Hyvisc,Luronit,Sodium Hyaluronate,Acid, Hyaluronic,Hyaluronate, Sodium,Vitrax, Amo
D001672 Biocompatible Materials Synthetic or natural materials, other than DRUGS, that are used to replace or repair any body TISSUES or bodily function. Biomaterials,Bioartificial Materials,Hemocompatible Materials,Bioartificial Material,Biocompatible Material,Biomaterial,Hemocompatible Material,Material, Bioartificial,Material, Biocompatible,Material, Hemocompatible
D020100 Hydrogels Water swollen, rigid, 3-dimensional network of cross-linked, hydrophilic macromolecules, 20-95% water. They are used in paints, printing inks, foodstuffs, pharmaceuticals, and cosmetics. (Grant & Hackh's Chemical Dictionary, 5th ed) Hydrogel,In Situ Hydrogel,In Situ Hydrogels,Patterned Hydrogel,Patterned Hydrogels,Hydrogel, In Situ,Hydrogel, Patterned

Related Publications

Xin Zhang, and Pengcheng Sun, and Lingzi Huangshan, and Bi-Huang Hu, and Phillip B Messersmith
Synthesis of guanidinium-modified hyaluronic Acid hydrogel.
July 2010, Macromolecular rapid communications,
Xin Zhang, and Pengcheng Sun, and Lingzi Huangshan, and Bi-Huang Hu, and Phillip B Messersmith
Synthesis by AGET ATRP of degradable nanogel precursors for in situ formation of nanostructured hyaluronic acid hydrogel.
September 2009, Biomacromolecules,
Xin Zhang, and Pengcheng Sun, and Lingzi Huangshan, and Bi-Huang Hu, and Phillip B Messersmith
Improved synthesis of hyaluronic acid hydrogel and its effect on tissue augmentation.
August 2012, Journal of biomaterials applications,
Xin Zhang, and Pengcheng Sun, and Lingzi Huangshan, and Bi-Huang Hu, and Phillip B Messersmith
In situ injectable hyaluronic acid/gelatin hydrogel for hemorrhage control.
May 2019, Materials science & engineering. C, Materials for biological applications,
Xin Zhang, and Pengcheng Sun, and Lingzi Huangshan, and Bi-Huang Hu, and Phillip B Messersmith
[PREPARATION AND BIOCOMPATIBILITY OF IN SITU CROSSLINKING HYALURONIC ACID HYDROGEL].
June 2016, Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery,
Xin Zhang, and Pengcheng Sun, and Lingzi Huangshan, and Bi-Huang Hu, and Phillip B Messersmith
Osteoconductive hybrid hyaluronic acid hydrogel patch for effective bone formation.
November 2020, Journal of controlled release : official journal of the Controlled Release Society,
Xin Zhang, and Pengcheng Sun, and Lingzi Huangshan, and Bi-Huang Hu, and Phillip B Messersmith
In Situ Forming Cellulose Nanofibril-Reinforced Hyaluronic Acid Hydrogel for Cartilage Regeneration.
December 2021, Biomacromolecules,
Xin Zhang, and Pengcheng Sun, and Lingzi Huangshan, and Bi-Huang Hu, and Phillip B Messersmith
In situ forming gelatin/hyaluronic acid hydrogel for tissue sealing and hemostasis.
April 2020, Journal of biomedical materials research. Part B, Applied biomaterials,
Xin Zhang, and Pengcheng Sun, and Lingzi Huangshan, and Bi-Huang Hu, and Phillip B Messersmith
Thermosensitive in situ hydrogel based on the hybrid of hyaluronic acid and modified PCL/PEG triblock copolymer.
August 2014, Carbohydrate polymers,
Xin Zhang, and Pengcheng Sun, and Lingzi Huangshan, and Bi-Huang Hu, and Phillip B Messersmith
Dual-Modified Hyaluronic Acid for Tunable Double Cross-Linked Hydrogel Adhesives.
April 2024, Biomacromolecules,
Copied contents to your clipboard!