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Alzheimer's disease (AD) is the most common type of dementia that leads to increasing death and mental disability among humans. Current therapy of AD mainly relies on the use of acetylcholinesterase inhibitors (AChEIs) or antagonists of N-methyl-D-aspartate receptors (NMDARs), which only relieve the symptoms of the disease but not halt its progression. Nevertheless, Traditional Chinese medicines (TCM) are highly prized as many bioactive components isolated from TCM are beneficial for treating AD. In this review, we summarize the latest information on TCM and the bioactive components according to their mechanistic role in alleviating AD. They act as modulators of α- and β-secretases, and inhibitors of betaamyloid (Aβ) aggregation. Some of them suppress Aβ-induced neuronal cytotoxicity and inflammation. Hence, this work has demonstrated the feasibility of applying TCM in AD therapy and the possibility of screening of constituents in TCM in the near future.
T S Cheung, and
T H Song, and
T B Ng, and
F H Wu, and
L X Lao, and
S C W Tang, and
J C M Ho, and
K Y B Zhang, and
S C W Sze
January 2017,
International review of neurobiology,
T S Cheung, and
T H Song, and
T B Ng, and
F H Wu, and
L X Lao, and
S C W Tang, and
J C M Ho, and
K Y B Zhang, and
S C W Sze
January 2022,
Evidence-based complementary and alternative medicine : eCAM,
T S Cheung, and
T H Song, and
T B Ng, and
F H Wu, and
L X Lao, and
S C W Tang, and
J C M Ho, and
K Y B Zhang, and
S C W Sze
July 1995,
Pharmacy world & science : PWS,
T S Cheung, and
T H Song, and
T B Ng, and
F H Wu, and
L X Lao, and
S C W Tang, and
J C M Ho, and
K Y B Zhang, and
S C W Sze
January 1992,
Report of proceedings. Scottish Society of the History of Medicine,
T S Cheung, and
T H Song, and
T B Ng, and
F H Wu, and
L X Lao, and
S C W Tang, and
J C M Ho, and
K Y B Zhang, and
S C W Sze
January 2020,
Folia neuropathologica,
T S Cheung, and
T H Song, and
T B Ng, and
F H Wu, and
L X Lao, and
S C W Tang, and
J C M Ho, and
K Y B Zhang, and
S C W Sze
May 2018,
Molecules (Basel, Switzerland),
T S Cheung, and
T H Song, and
T B Ng, and
F H Wu, and
L X Lao, and
S C W Tang, and
J C M Ho, and
K Y B Zhang, and
S C W Sze
March 2003,
Anaesthesia,
T S Cheung, and
T H Song, and
T B Ng, and
F H Wu, and
L X Lao, and
S C W Tang, and
J C M Ho, and
K Y B Zhang, and
S C W Sze
March 2015,
Journal of the Chinese Medical Association : JCMA,
T S Cheung, and
T H Song, and
T B Ng, and
F H Wu, and
L X Lao, and
S C W Tang, and
J C M Ho, and
K Y B Zhang, and
S C W Sze
November 2002,
Anaesthesia,
T S Cheung, and
T H Song, and
T B Ng, and
F H Wu, and
L X Lao, and
S C W Tang, and
J C M Ho, and
K Y B Zhang, and
S C W Sze
January 2015,
Evidence-based complementary and alternative medicine : eCAM,
