Circulating lymphocyte and T memory subsets in glucocorticosteroid versus IVIG treated patients with CIDP. 2015

Juliane Klehmet, and Max Staudt, and Lena Ulm, and Nadine Unterwalder, and Andreas Meisel, and Christian Meisel
Department of Neurology, Charité Universitaetsmedizin, Charitéplatz 1, Berlin, Germany. Electronic address: juliane.klehmet@charite.de.

The present study compared lymphocyte and T memory subsets in currently untreated patients with chronic inflammatory demyelinating polyneuropathy (CIDP) to glucocorticosteroid (GS) and intravenous immunoglobulin (IVIG) treated patients. Peripheral blood from 48 CIDP patients (21 untreated who were either treatment naïve or without treatment during the last 3 months, 17 IVIG and 10 GS treatment) and from 12 age-matched controls was evaluated using flow cytometric analysis. Our data demonstrate that long-term GS treatment is associated with reduced frequencies of total CD4+ T cells, CD4+ memory subsets and NK cells while long-term IVIG treatment is associated with alterations of the CD8+ memory compartment. Reduction of CD4+ naïve T cell counts may explain the observation that GS treatment induces prolonged clinical remission compared to IVIG treatment.

UI MeSH Term Description Entries
D007155 Immunologic Factors Biologically active substances whose activities affect or play a role in the functioning of the immune system. Biological Response Modifier,Biomodulator,Immune Factor,Immunological Factor,Immunomodulator,Immunomodulators,Biological Response Modifiers,Biomodulators,Factors, Immunologic,Immune Factors,Immunological Factors,Modifiers, Biological Response,Response Modifiers, Biological,Factor, Immune,Factor, Immunological,Factors, Immune,Factors, Immunological,Modifier, Biological Response,Response Modifier, Biological
D007156 Immunologic Memory The altered state of immunologic responsiveness resulting from initial contact with antigen, which enables the individual to produce antibodies more rapidly and in greater quantity in response to secondary antigenic stimulus. Immune Memory,Immunological Memory,Memory, Immunologic,Immune Memories,Immunologic Memories,Immunological Memories,Memory, Immune,Memory, Immunological
D007166 Immunosuppressive Agents Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging. Immunosuppressant,Immunosuppressive Agent,Immunosuppressants,Agent, Immunosuppressive,Agents, Immunosuppressive
D007694 Killer Cells, Natural Bone marrow-derived lymphocytes that possess cytotoxic properties, classically directed against transformed and virus-infected cells. Unlike T CELLS; and B CELLS; NK CELLS are not antigen specific. The cytotoxicity of natural killer cells is determined by the collective signaling of an array of inhibitory and stimulatory CELL SURFACE RECEPTORS. A subset of T-LYMPHOCYTES referred to as NATURAL KILLER T CELLS shares some of the properties of this cell type. NK Cells,Natural Killer Cells,Cell, NK,Cell, Natural Killer,Cells, NK,Cells, Natural Killer,Killer Cell, Natural,NK Cell,Natural Killer Cell
D008297 Male Males
D008775 Methylprednisolone A PREDNISOLONE derivative with similar anti-inflammatory action. 6-Methylprednisolone,Medrol,Metipred,Urbason,6 Methylprednisolone
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009000 Monocytes Large, phagocytic mononuclear leukocytes produced in the vertebrate BONE MARROW and released into the BLOOD; contain a large, oval or somewhat indented nucleus surrounded by voluminous cytoplasm and numerous organelles. Monocyte
D011239 Prednisolone A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states. Di-Adreson-F,Predate,Predonine,Di Adreson F,DiAdresonF
D005260 Female Females

Related Publications

Juliane Klehmet, and Max Staudt, and Lena Ulm, and Nadine Unterwalder, and Andreas Meisel, and Christian Meisel
November 2002, American journal of reproductive immunology (New York, N.Y. : 1989),
Juliane Klehmet, and Max Staudt, and Lena Ulm, and Nadine Unterwalder, and Andreas Meisel, and Christian Meisel
December 1994, Endocrine journal,
Juliane Klehmet, and Max Staudt, and Lena Ulm, and Nadine Unterwalder, and Andreas Meisel, and Christian Meisel
February 2023, International immunopharmacology,
Juliane Klehmet, and Max Staudt, and Lena Ulm, and Nadine Unterwalder, and Andreas Meisel, and Christian Meisel
January 1990, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie,
Juliane Klehmet, and Max Staudt, and Lena Ulm, and Nadine Unterwalder, and Andreas Meisel, and Christian Meisel
January 1986, Acta dermato-venereologica,
Juliane Klehmet, and Max Staudt, and Lena Ulm, and Nadine Unterwalder, and Andreas Meisel, and Christian Meisel
January 2023, Muscle & nerve,
Juliane Klehmet, and Max Staudt, and Lena Ulm, and Nadine Unterwalder, and Andreas Meisel, and Christian Meisel
January 1984, Neuropsychobiology,
Juliane Klehmet, and Max Staudt, and Lena Ulm, and Nadine Unterwalder, and Andreas Meisel, and Christian Meisel
July 1987, International journal of clinical pharmacology, therapy, and toxicology,
Juliane Klehmet, and Max Staudt, and Lena Ulm, and Nadine Unterwalder, and Andreas Meisel, and Christian Meisel
March 1998, Clinical and experimental immunology,
Juliane Klehmet, and Max Staudt, and Lena Ulm, and Nadine Unterwalder, and Andreas Meisel, and Christian Meisel
October 1994, Journal of neuroimmunology,
Copied contents to your clipboard!