Effects of intra-abdominal pressure on adrenal gland function and morphology in rats. 2015

Nezih Akkapulu, and Mehmet Bulent Tirnaksiz, and Ibrahim Kulac, and Gaye Guler Tezel, and Mutlu Hayran, and Ahmet Bulent Dogrul, and Erdinc Cetinkaya, and Kaya Yorganci
Department of General Surgery, Hacettepe University School of Medicine, Ankara, Turkey.

Intra-abdominal hypertension and abdominal compartment syndrome (IAH/ACS) are life-threatening conditions and caused by several clinical status. Although there is insufficient data regarding its effects on adrenal glands. This study aimed to identify whether elevated intra-abdominal pressure (IAP) caused any alteration on the morphology and function of adrenal glands in a rat model. Twenty four Sprague-Dawley male rats were included in the study. Animals were allocated into 4 groups. IAP was elevated to 15 mmHg for one hour and four hours in group 2 and 4. Group 1 and 3 were sham groups. Blood samples were taken for the assessment of plasma adrenaline, noradrenaline, and corticosterone levels and adrenalectomies were performed to evaluate apoptosis. Blood adrenaline, noradrenaline and corticosterone levels were significantly higher in the study groups compared with the sham groups. However, there were no significant changes in apoptotic index scores in the study groups as compared to sham groups. These results support that increased IAH leads to discharge of catecholamine and corticosterone from the adrenal glands. Failure to demonstrate similar changes in apoptotic index score may be concluded as apoptosis is not a leading pathway for impairment of adrenal glands during IAH period.

UI MeSH Term Description Entries
D008297 Male Males
D009638 Norepinephrine Precursor of epinephrine that is secreted by the ADRENAL MEDULLA and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers, and of the diffuse projection system in the brain that arises from the LOCUS CERULEUS. It is also found in plants and is used pharmacologically as a sympathomimetic. Levarterenol,Levonorepinephrine,Noradrenaline,Arterenol,Levonor,Levophed,Levophed Bitartrate,Noradrenaline Bitartrate,Noradrénaline tartrate renaudin,Norepinephrin d-Tartrate (1:1),Norepinephrine Bitartrate,Norepinephrine Hydrochloride,Norepinephrine Hydrochloride, (+)-Isomer,Norepinephrine Hydrochloride, (+,-)-Isomer,Norepinephrine d-Tartrate (1:1),Norepinephrine l-Tartrate (1:1),Norepinephrine l-Tartrate (1:1), (+,-)-Isomer,Norepinephrine l-Tartrate (1:1), Monohydrate,Norepinephrine l-Tartrate (1:1), Monohydrate, (+)-Isomer,Norepinephrine l-Tartrate (1:2),Norepinephrine l-Tartrate, (+)-Isomer,Norepinephrine, (+)-Isomer,Norepinephrine, (+,-)-Isomer
D003345 Corticosterone An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437)
D004195 Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. Animal Disease Model,Animal Disease Models,Disease Model, Animal
D004837 Epinephrine The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS. Adrenaline,4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol,Adrenaline Acid Tartrate,Adrenaline Bitartrate,Adrenaline Hydrochloride,Epifrin,Epinephrine Acetate,Epinephrine Bitartrate,Epinephrine Hydrochloride,Epinephrine Hydrogen Tartrate,Epitrate,Lyophrin,Medihaler-Epi,Acetate, Epinephrine
D000311 Adrenal Glands A pair of glands located at the cranial pole of each of the two KIDNEYS. Each adrenal gland is composed of two distinct endocrine tissues with separate embryonic origins, the ADRENAL CORTEX producing STEROIDS and the ADRENAL MEDULLA producing NEUROTRANSMITTERS. Adrenal Gland,Gland, Adrenal,Glands, Adrenal
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D017207 Rats, Sprague-Dawley A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company. Holtzman Rat,Rats, Holtzman,Sprague-Dawley Rat,Rats, Sprague Dawley,Holtzman Rats,Rat, Holtzman,Rat, Sprague-Dawley,Sprague Dawley Rat,Sprague Dawley Rats,Sprague-Dawley Rats
D017209 Apoptosis A regulated cell death mechanism characterized by distinctive morphologic changes in the nucleus and cytoplasm, including the endonucleolytic cleavage of genomic DNA, at regularly spaced, internucleosomal sites, i.e., DNA FRAGMENTATION. It is genetically programmed and serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth. Apoptosis, Extrinsic Pathway,Apoptosis, Intrinsic Pathway,Caspase-Dependent Apoptosis,Classic Apoptosis,Classical Apoptosis,Programmed Cell Death,Programmed Cell Death, Type I,Apoptoses, Extrinsic Pathway,Apoptoses, Intrinsic Pathway,Apoptosis, Caspase-Dependent,Apoptosis, Classic,Apoptosis, Classical,Caspase Dependent Apoptosis,Cell Death, Programmed,Classic Apoptoses,Extrinsic Pathway Apoptoses,Extrinsic Pathway Apoptosis,Intrinsic Pathway Apoptoses,Intrinsic Pathway Apoptosis
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

Related Publications

Nezih Akkapulu, and Mehmet Bulent Tirnaksiz, and Ibrahim Kulac, and Gaye Guler Tezel, and Mutlu Hayran, and Ahmet Bulent Dogrul, and Erdinc Cetinkaya, and Kaya Yorganci
June 2016, Aesthetic surgery journal,
Nezih Akkapulu, and Mehmet Bulent Tirnaksiz, and Ibrahim Kulac, and Gaye Guler Tezel, and Mutlu Hayran, and Ahmet Bulent Dogrul, and Erdinc Cetinkaya, and Kaya Yorganci
April 2009, Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns,
Nezih Akkapulu, and Mehmet Bulent Tirnaksiz, and Ibrahim Kulac, and Gaye Guler Tezel, and Mutlu Hayran, and Ahmet Bulent Dogrul, and Erdinc Cetinkaya, and Kaya Yorganci
December 2012, The Veterinary record,
Nezih Akkapulu, and Mehmet Bulent Tirnaksiz, and Ibrahim Kulac, and Gaye Guler Tezel, and Mutlu Hayran, and Ahmet Bulent Dogrul, and Erdinc Cetinkaya, and Kaya Yorganci
June 1990, Journal of steroid biochemistry,
Nezih Akkapulu, and Mehmet Bulent Tirnaksiz, and Ibrahim Kulac, and Gaye Guler Tezel, and Mutlu Hayran, and Ahmet Bulent Dogrul, and Erdinc Cetinkaya, and Kaya Yorganci
March 2012, Respiratory physiology & neurobiology,
Nezih Akkapulu, and Mehmet Bulent Tirnaksiz, and Ibrahim Kulac, and Gaye Guler Tezel, and Mutlu Hayran, and Ahmet Bulent Dogrul, and Erdinc Cetinkaya, and Kaya Yorganci
January 2013, PloS one,
Nezih Akkapulu, and Mehmet Bulent Tirnaksiz, and Ibrahim Kulac, and Gaye Guler Tezel, and Mutlu Hayran, and Ahmet Bulent Dogrul, and Erdinc Cetinkaya, and Kaya Yorganci
November 1982, Annals of surgery,
Nezih Akkapulu, and Mehmet Bulent Tirnaksiz, and Ibrahim Kulac, and Gaye Guler Tezel, and Mutlu Hayran, and Ahmet Bulent Dogrul, and Erdinc Cetinkaya, and Kaya Yorganci
November 2003, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
Nezih Akkapulu, and Mehmet Bulent Tirnaksiz, and Ibrahim Kulac, and Gaye Guler Tezel, and Mutlu Hayran, and Ahmet Bulent Dogrul, and Erdinc Cetinkaya, and Kaya Yorganci
December 1977, Indian journal of experimental biology,
Nezih Akkapulu, and Mehmet Bulent Tirnaksiz, and Ibrahim Kulac, and Gaye Guler Tezel, and Mutlu Hayran, and Ahmet Bulent Dogrul, and Erdinc Cetinkaya, and Kaya Yorganci
June 2006, British journal of anaesthesia,
Copied contents to your clipboard!