-transparent.png){kind=logo}
One-pot reaction to obtain N,N'-disubstituted guanidines of pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine scaffold as human A3 adenosine receptor antagonists. 2015
Pier Giovanni Baraldi, and
Stefania Baraldi, and
Giulia Saponaro, and
Mojgan Aghazadeh Tabrizi, and
Romeo Romagnoli, and
Emanuela Ruggiero, and
Fabrizio Vincenzi, and
Pier Andrea Borea, and
Katia Varani
†Dipartimento di Scienze Chimiche e Farmaceutiche, Università degli Studi di Ferrara, Via Fossato di Mortara 17, 44121 Ferrara, Italy.
In this paper we describe an extension SAR study of pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine nucleus as A3AR antagonist. Our initial aim was to replace the phenylcarbamoyl moiety at the 5 position of PTP nucleus with a thiourea functionality to evaluate the contribution of new structural modification against the A3AR. The synthesized 12-25 were not characterized by the predicted side chain but by a 1,3-disubstituted guanidine and are shown to be interesting A3AR antagonists.
Related Publications
Pier Giovanni Baraldi, and
Stefania Baraldi, and
Giulia Saponaro, and
Mojgan Aghazadeh Tabrizi, and
Romeo Romagnoli, and
Emanuela Ruggiero, and
Fabrizio Vincenzi, and
Pier Andrea Borea, and
Katia Varani
January 2011,
Bioorganic & medicinal chemistry letters,
Pier Giovanni Baraldi, and
Stefania Baraldi, and
Giulia Saponaro, and
Mojgan Aghazadeh Tabrizi, and
Romeo Romagnoli, and
Emanuela Ruggiero, and
Fabrizio Vincenzi, and
Pier Andrea Borea, and
Katia Varani
January 2016,
Current topics in medicinal chemistry,
Pier Giovanni Baraldi, and
Stefania Baraldi, and
Giulia Saponaro, and
Mojgan Aghazadeh Tabrizi, and
Romeo Romagnoli, and
Emanuela Ruggiero, and
Fabrizio Vincenzi, and
Pier Andrea Borea, and
Katia Varani
March 2007,
Bioorganic & medicinal chemistry letters,
Pier Giovanni Baraldi, and
Stefania Baraldi, and
Giulia Saponaro, and
Mojgan Aghazadeh Tabrizi, and
Romeo Romagnoli, and
Emanuela Ruggiero, and
Fabrizio Vincenzi, and
Pier Andrea Borea, and
Katia Varani
May 2004,
Bioorganic & medicinal chemistry letters,
Pier Giovanni Baraldi, and
Stefania Baraldi, and
Giulia Saponaro, and
Mojgan Aghazadeh Tabrizi, and
Romeo Romagnoli, and
Emanuela Ruggiero, and
Fabrizio Vincenzi, and
Pier Andrea Borea, and
Katia Varani
October 2013,
Archiv der Pharmazie,
Pier Giovanni Baraldi, and
Stefania Baraldi, and
Giulia Saponaro, and
Mojgan Aghazadeh Tabrizi, and
Romeo Romagnoli, and
Emanuela Ruggiero, and
Fabrizio Vincenzi, and
Pier Andrea Borea, and
Katia Varani
May 2011,
Bioorganic & medicinal chemistry letters,
Pier Giovanni Baraldi, and
Stefania Baraldi, and
Giulia Saponaro, and
Mojgan Aghazadeh Tabrizi, and
Romeo Romagnoli, and
Emanuela Ruggiero, and
Fabrizio Vincenzi, and
Pier Andrea Borea, and
Katia Varani
August 2017,
MedChemComm,
Pier Giovanni Baraldi, and
Stefania Baraldi, and
Giulia Saponaro, and
Mojgan Aghazadeh Tabrizi, and
Romeo Romagnoli, and
Emanuela Ruggiero, and
Fabrizio Vincenzi, and
Pier Andrea Borea, and
Katia Varani
July 2008,
Molecules (Basel, Switzerland),
Pier Giovanni Baraldi, and
Stefania Baraldi, and
Giulia Saponaro, and
Mojgan Aghazadeh Tabrizi, and
Romeo Romagnoli, and
Emanuela Ruggiero, and
Fabrizio Vincenzi, and
Pier Andrea Borea, and
Katia Varani
July 2019,
MedChemComm,
Pier Giovanni Baraldi, and
Stefania Baraldi, and
Giulia Saponaro, and
Mojgan Aghazadeh Tabrizi, and
Romeo Romagnoli, and
Emanuela Ruggiero, and
Fabrizio Vincenzi, and
Pier Andrea Borea, and
Katia Varani
January 2016,
European journal of medicinal chemistry,
