BIOMAT Database Logo BIOMAT Database Logo

Circulating sex hormone-binding globulin and testosterone in newborns and infants. 1989

N J Bolton, and J Tapanainen, and M Koivisto, and R Vihko
Department of Clinical Chemistry, University of Oulu, Finland.

The concentrations of sex hormone-binding globulin (SHBG) and testosterone (T) were measured in the cord blood of full-term newborns (14 boys, 15 girls) and pre-term newborns (10 boys, 5 girls), and in the venous circulation of 100 full-term infants aged 1-204 days. The ratio of T to SHBG (the 'free androgen index', FAI) was calculated to reflect the level of unbound T (the free, biologically active fraction). In boys' umbilical cord sera, T concentrations were significantly greater in arterial than in venous sera, while there was no such difference in the concentration of SHBG. Levels of SHBG in cord sera were considerably lower than those seen in the maternal circulation at term, but they were significantly greater in boys' than in girls' cord sera. Levels of T, and the FAI, were significantly greater in boys' arterial cord sera than in girls'. In early infancy, SHBG concentrations rose in both sexes, the highest values being seen in girls. In infant girls, levels of T and the FAI were constantly low. In infant boys, the expected peak in serum T concentrations was observed at 1-3 months the values approaching those seen in men. In contrast, values of the FAI at this age were relatively low, similar to those seen in women. This suggests that the elevation of male serum T during the first months of life lacks biological significance. However, it is important to realise that the FAI in male infants is about one order of magnitude larger than that in female infants at this time.

UI MeSH Term Description Entries
D007223 Infant A child between 1 and 23 months of age. Infants
D007231 Infant, Newborn An infant during the first 28 days after birth. Neonate,Newborns,Infants, Newborn,Neonates,Newborn,Newborn Infant,Newborn Infants
D008297 Male Males
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000728 Androgens Compounds that interact with ANDROGEN RECEPTORS in target tissues to bring about the effects similar to those of TESTOSTERONE. Depending on the target tissues, androgenic effects can be on SEX DIFFERENTIATION; male reproductive organs, SPERMATOGENESIS; secondary male SEX CHARACTERISTICS; LIBIDO; development of muscle mass, strength, and power. Androgen,Androgen Receptor Agonist,Androgen Effect,Androgen Effects,Androgen Receptor Agonists,Androgenic Agents,Androgenic Compounds,Agents, Androgenic,Agonist, Androgen Receptor,Agonists, Androgen Receptor,Compounds, Androgenic,Effect, Androgen,Effects, Androgen,Receptor Agonist, Androgen,Receptor Agonists, Androgen
D012738 Sex Hormone-Binding Globulin A glycoprotein migrating as a beta-globulin. Its molecular weight, 52,000 or 95,000-115,000, indicates that it exists as a dimer. The protein binds testosterone, dihydrotestosterone, and estradiol in the plasma. Sex hormone-binding protein has the same amino acid sequence as ANDROGEN-BINDING PROTEIN. They differ by their sites of synthesis and post-translational oligosaccharide modifications. Sex Steroid-Binding Protein,Testosterone-Estradiol Binding Globulin,Binding Globulin, Testosterone-Estradiol,Globulin, Sex Hormone-Binding,Globulin, Testosterone-Estradiol Binding,Hormone-Binding Globulin, Sex,Sex Hormone Binding Globulin,Sex Steroid Binding Protein,Steroid-Binding Protein, Sex,Testosterone Estradiol Binding Globulin
D013739 Testosterone A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL. 17-beta-Hydroxy-4-Androsten-3-one,17-beta-Hydroxy-8 alpha-4-Androsten-3-one,8-Isotestosterone,AndroGel,Androderm,Andropatch,Androtop,Histerone,Sterotate,Sustanon,Testim,Testoderm,Testolin,Testopel,Testosterone Sulfate,17 beta Hydroxy 4 Androsten 3 one,17 beta Hydroxy 8 alpha 4 Androsten 3 one,8 Isotestosterone

Related Publications

N J Bolton, and J Tapanainen, and M Koivisto, and R Vihko
Circulating sex hormone binding globulin (SHBG) and testosterone levels in patients with anorexia nervosa.
January 1985, Gaoxiong yi xue ke xue za zhi = The Kaohsiung journal of medical sciences,
N J Bolton, and J Tapanainen, and M Koivisto, and R Vihko
Differential effects of exercise on sex hormone-binding globulin and non-sex hormone-binding globulin-bound testosterone.
January 1996, European journal of applied physiology and occupational physiology,
N J Bolton, and J Tapanainen, and M Koivisto, and R Vihko
Circadian variation in testosterone, sex hormone-binding globulin, and calculated non-sex hormone-binding globulin bound testosterone in healthy young and elderly men.
January 1989, Journal of andrology,
N J Bolton, and J Tapanainen, and M Koivisto, and R Vihko
Circulating sex steroids and sex hormone binding globulin in pancreatic adenocarcinoma.
January 1986, Anticancer research,
N J Bolton, and J Tapanainen, and M Koivisto, and R Vihko
Testosterone, sex hormone-binding globulin, and frailty in older men.
April 2007, Journal of the American Geriatrics Society,
N J Bolton, and J Tapanainen, and M Koivisto, and R Vihko
Genome-wide association study of circulating estradiol, testosterone, and sex hormone-binding globulin in postmenopausal women.
January 2012, PloS one,
N J Bolton, and J Tapanainen, and M Koivisto, and R Vihko
Changes in serum sex hormone-binding globulin and in serum non-sex hormone-binding globulin-bound testosterone during prepuberty in boys.
January 1987, Journal of steroid biochemistry,
N J Bolton, and J Tapanainen, and M Koivisto, and R Vihko
Testosterone, sex hormone-binding globulin, lipoproteins, and vascular disease risk.
January 1997, Journal of cardiovascular risk,
N J Bolton, and J Tapanainen, and M Koivisto, and R Vihko
Association of total testosterone, free testosterone, bioavailable testosterone, sex hormone-binding globulin, and hypertension.
May 2019, Medicine,
N J Bolton, and J Tapanainen, and M Koivisto, and R Vihko
Sex hormone-binding globulin and testosterone in individuals with childhood diabetes.
June 2008, Diabetes care,
Copied contents to your clipboard!