-transparent.png){kind=logo}
We purified xUBF on the basis of its ability to specifically bind the enhancer elements of the Xenopus laevis rRNA genes. xUBF also binds to both upstream and downstream regions of the X. laevis ribosomal gene promoter and is essential for polymerase I transcription. Unexpectedly, xUBF binds to both upstream and downstream regions of the human ribosomal gene promoter, producing footprints that are indistinguishable from the footprints produced by hUBF, a previously described polymerase I transcription factor isolated from human cells. Despite extensive sequence divergence of vertebrate polymerase I promoters, these data suggest an evolutionary conservation of the primary DNA-protein interaction.
C S Pikaard, and
B McStay, and
M C Schultz, and
S P Bell, and
R H Reeder
November 1992,
Molecular and cellular biology,
C S Pikaard, and
B McStay, and
M C Schultz, and
S P Bell, and
R H Reeder
November 1991,
Genes & development,
C S Pikaard, and
B McStay, and
M C Schultz, and
S P Bell, and
R H Reeder
July 1992,
Nucleic acids research,
C S Pikaard, and
B McStay, and
M C Schultz, and
S P Bell, and
R H Reeder
February 1993,
The EMBO journal,
C S Pikaard, and
B McStay, and
M C Schultz, and
S P Bell, and
R H Reeder
May 1994,
Molecular and cellular biology,
C S Pikaard, and
B McStay, and
M C Schultz, and
S P Bell, and
R H Reeder
January 1994,
Proceedings of the National Academy of Sciences of the United States of America,
C S Pikaard, and
B McStay, and
M C Schultz, and
S P Bell, and
R H Reeder
August 1991,
FEBS letters,
C S Pikaard, and
B McStay, and
M C Schultz, and
S P Bell, and
R H Reeder
May 1991,
Nucleic acids research,
C S Pikaard, and
B McStay, and
M C Schultz, and
S P Bell, and
R H Reeder
May 1994,
Science (New York, N.Y.),
C S Pikaard, and
B McStay, and
M C Schultz, and
S P Bell, and
R H Reeder
April 1993,
DNA and cell biology,
