The Effect of Low Omega-3/Omega-6 Ratio on Auditory Nerve Conduction in Rat Pups. 2015

Saeid Farahani, and Masoud Motasaddi Zarandy, and Gholamreza Hassanzadeh, and Farzad Shidfar, and Shohreh Jalaie, and Vida Rahimi
Department of Audiology , School of Rehabilitation, Tehran University of Medical Sciences,Tehran,Iran. s_farahani@tums.ac.ir.

The biological effects of omega-3 and omega-6 fatty acids are determined by their mutual interactions. This interaction extremely affects various functions. Lower consumption of omega-3 during gestation leads to various disorders, even in hearing. We aimed to assess the effect of low omega-3/omega-6 ratios on auditory nerve conduction. In this experimental study, the auditory brainstem response test was performed on 24-day-old rat (n=14). The rats were divided into case (low omega-3/omega-6 ratio during gestation and lactation) and control groups. Variables such as P1, P3, and P4 absolute latency period, interpeaks (P3-P4, P1-P3, and P1-P4), and P4/P1 amplitude ratio were measured. We found an increased P4 omega-3/omega-6 ratio in the group with a low omega-3/omega-6 ratio (P<0.01). No significant difference was observed in the P1 and P3 absolute latency period between the studied groups  (P>0.05).  Also, no significant difference was observed between the groups with respect to the P1-P3 interpeak latency (IPL) periods (P>0.05); while the P1-P4 and P3-P4 IPLs were significantly increased in the group with a low omega-3/omega-6 ratio (P<0.05). The P4/P1 amplitude ratio significantly decreased in the group with a low omega-3/omega-6 ratio (P<0.05). Results confirmed the negative effects of low omega-3/omega-6 ratio on the auditory system and hearing.

UI MeSH Term Description Entries
D008297 Male Males
D009431 Neural Conduction The propagation of the NERVE IMPULSE along the nerve away from the site of an excitation stimulus. Nerve Conduction,Conduction, Nerve,Conduction, Neural,Conductions, Nerve,Conductions, Neural,Nerve Conductions,Neural Conductions
D005260 Female Females
D006309 Hearing The ability or act of sensing and transducing ACOUSTIC STIMULATION to the CENTRAL NERVOUS SYSTEM. It is also called audition. Audition
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D015525 Fatty Acids, Omega-3 A group of unsaturated fatty acids occurring mainly in fish oils, with three double bonds at particular positions in the hydrocarbon chain. N-3 Fatty Acid,Omega-3 Fatty Acid,Omega-3 Fatty Acids,n-3 Fatty Acids,n-3 Oil,n3 Oil,Omega 3 Fatty Acids,n-3 Oils,n-3 PUFA,n-3 Polyunsaturated Fatty Acid,n3 Fatty Acid,n3 Oils,n3 PUFA,n3 Polyunsaturated Fatty Acid,Acid, N-3 Fatty,Acid, Omega-3 Fatty,Fatty Acid, N-3,Fatty Acid, Omega-3,Fatty Acid, n3,N 3 Fatty Acid,Oil, n-3,Oil, n3,Omega 3 Fatty Acid,PUFA, n-3,PUFA, n3,n 3 Fatty Acids,n 3 Oil,n 3 Oils,n 3 PUFA,n 3 Polyunsaturated Fatty Acid
D016057 Evoked Potentials, Auditory, Brain Stem Electrical waves in the CEREBRAL CORTEX generated by BRAIN STEM structures in response to auditory click stimuli. These are found to be abnormal in many patients with CEREBELLOPONTINE ANGLE lesions, MULTIPLE SCLEROSIS, or other DEMYELINATING DISEASES. Acoustic Evoked Brain Stem Potentials,Auditory Brain Stem Evoked Responses,Brain Stem Auditory Evoked Potentials,Evoked Responses, Auditory, Brain Stem,Acoustic Evoked Brain Stem Potential,Acoustic Evoked Brainstem Potential,Acoustic Evoked Brainstem Potentials,Auditory Brain Stem Evoked Response,Auditory Brain Stem Response,Auditory Brain Stem Responses,Auditory Brainstem Evoked Response,Auditory Brainstem Evoked Responses,Auditory Brainstem Responses,Brain Stem Auditory Evoked Potential,Brainstem Auditory Evoked Potential,Brainstem Auditory Evoked Potentials,Evoked Potential, Auditory, Brainstem,Evoked Potentials, Auditory, Brainstem,Evoked Response, Auditory, Brain Stem,Evoked Response, Auditory, Brainstem,Evoked Responses, Auditory, Brainstem,Auditory Brainstem Response,Brainstem Response, Auditory,Brainstem Responses, Auditory,Response, Auditory Brainstem,Responses, Auditory Brainstem
D017208 Rats, Wistar A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain. Wistar Rat,Rat, Wistar,Wistar Rats
D043371 Fatty Acids, Omega-6 FATTY ACIDS which have the first unsaturated bond in the sixth position from the omega carbon. A typical American diet tends to contain substantially more omega-6 than OMEGA-3 FATTY ACIDS. N-6 Fatty Acid,Omega-6 Fatty Acid,Omega-6 Fatty Acids,Fatty Acids, Omega 6,N-6 Fatty Acids,Acid, N-6 Fatty,Acid, Omega-6 Fatty,Acids, N-6 Fatty,Acids, Omega-6 Fatty,Fatty Acid, N-6,Fatty Acid, Omega-6,Fatty Acids, N-6,N 6 Fatty Acid,N 6 Fatty Acids,Omega 6 Fatty Acid,Omega 6 Fatty Acids
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

Related Publications

Saeid Farahani, and Masoud Motasaddi Zarandy, and Gholamreza Hassanzadeh, and Farzad Shidfar, and Shohreh Jalaie, and Vida Rahimi
February 1996, Biochemical Society transactions,
Saeid Farahani, and Masoud Motasaddi Zarandy, and Gholamreza Hassanzadeh, and Farzad Shidfar, and Shohreh Jalaie, and Vida Rahimi
January 2013, Nutricion hospitalaria,
Saeid Farahani, and Masoud Motasaddi Zarandy, and Gholamreza Hassanzadeh, and Farzad Shidfar, and Shohreh Jalaie, and Vida Rahimi
June 2014, Acta cirurgica brasileira,
Saeid Farahani, and Masoud Motasaddi Zarandy, and Gholamreza Hassanzadeh, and Farzad Shidfar, and Shohreh Jalaie, and Vida Rahimi
December 2011, Prostaglandins, leukotrienes, and essential fatty acids,
Saeid Farahani, and Masoud Motasaddi Zarandy, and Gholamreza Hassanzadeh, and Farzad Shidfar, and Shohreh Jalaie, and Vida Rahimi
January 2018, Open heart,
Saeid Farahani, and Masoud Motasaddi Zarandy, and Gholamreza Hassanzadeh, and Farzad Shidfar, and Shohreh Jalaie, and Vida Rahimi
August 2011, Lipids in health and disease,
Saeid Farahani, and Masoud Motasaddi Zarandy, and Gholamreza Hassanzadeh, and Farzad Shidfar, and Shohreh Jalaie, and Vida Rahimi
January 2000, Developmental neuroscience,
Saeid Farahani, and Masoud Motasaddi Zarandy, and Gholamreza Hassanzadeh, and Farzad Shidfar, and Shohreh Jalaie, and Vida Rahimi
January 2011, Acta cirurgica brasileira,
Saeid Farahani, and Masoud Motasaddi Zarandy, and Gholamreza Hassanzadeh, and Farzad Shidfar, and Shohreh Jalaie, and Vida Rahimi
March 2017, Acta medica portuguesa,
Saeid Farahani, and Masoud Motasaddi Zarandy, and Gholamreza Hassanzadeh, and Farzad Shidfar, and Shohreh Jalaie, and Vida Rahimi
January 2003, World review of nutrition and dietetics,
Copied contents to your clipboard!