-transparent.png){kind=logo}
Pharmacokinetic and clinical studies on a new cephalosporin antibiotic, cefodizime (THR-221, CDZM), were performed and the results obtained are summarized as follows: 1. At about 84 minutes after a bolus injection of 1 g dose of CDZM, the drug was transferred well into tissues of internal genital organs and remained there at therapeutic levels for 285 minutes. The drug was also transferred quickly and sufficiently into exudate from pelvic dead space and its levels were still kept at high levels at 6 hours after administration. 2. CDZM was given to 8 women affected with gynecologic infections. The outcome of CDZM therapies showed that the drug was effective in all 8 of patients (100%) clinically and bacteriologically. 3. Notable adverse effects or abnormal laboratory test results were not observed except for 2 patients with transient and slight elevation of transaminase levels. Based on these results, it may be concluded that CDZM is a highly effective and a very safe antibiotic for the treatment on infectious diseases in gynecologic field.
S Hanada, and
T Kinbara, and
K Aoki, and
Y Yasui, and
K Ikuta, and
M Manzai, and
K Mizuno, and
Y Yagami, and
H Sakaida, and
Y Okumura
May 1989,
The Japanese journal of antibiotics,
S Hanada, and
T Kinbara, and
K Aoki, and
Y Yasui, and
K Ikuta, and
M Manzai, and
K Mizuno, and
Y Yagami, and
H Sakaida, and
Y Okumura
October 1989,
The Japanese journal of antibiotics,
S Hanada, and
T Kinbara, and
K Aoki, and
Y Yasui, and
K Ikuta, and
M Manzai, and
K Mizuno, and
Y Yagami, and
H Sakaida, and
Y Okumura
October 1989,
The Japanese journal of antibiotics,
S Hanada, and
T Kinbara, and
K Aoki, and
Y Yasui, and
K Ikuta, and
M Manzai, and
K Mizuno, and
Y Yagami, and
H Sakaida, and
Y Okumura
October 1989,
The Japanese journal of antibiotics,
S Hanada, and
T Kinbara, and
K Aoki, and
Y Yasui, and
K Ikuta, and
M Manzai, and
K Mizuno, and
Y Yagami, and
H Sakaida, and
Y Okumura
January 1989,
The Japanese journal of antibiotics,
S Hanada, and
T Kinbara, and
K Aoki, and
Y Yasui, and
K Ikuta, and
M Manzai, and
K Mizuno, and
Y Yagami, and
H Sakaida, and
Y Okumura
October 1989,
The Japanese journal of antibiotics,
S Hanada, and
T Kinbara, and
K Aoki, and
Y Yasui, and
K Ikuta, and
M Manzai, and
K Mizuno, and
Y Yagami, and
H Sakaida, and
Y Okumura
June 1989,
The Japanese journal of antibiotics,
S Hanada, and
T Kinbara, and
K Aoki, and
Y Yasui, and
K Ikuta, and
M Manzai, and
K Mizuno, and
Y Yagami, and
H Sakaida, and
Y Okumura
October 1989,
The Japanese journal of antibiotics,
S Hanada, and
T Kinbara, and
K Aoki, and
Y Yasui, and
K Ikuta, and
M Manzai, and
K Mizuno, and
Y Yagami, and
H Sakaida, and
Y Okumura
June 1989,
The Japanese journal of antibiotics,
S Hanada, and
T Kinbara, and
K Aoki, and
Y Yasui, and
K Ikuta, and
M Manzai, and
K Mizuno, and
Y Yagami, and
H Sakaida, and
Y Okumura
June 1989,
The Japanese journal of antibiotics,
