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The anticonvulsive action of vanillin, an antiepileptic agent structurally related to vanillyl alcohol isolated from Gastrodia elata Blume, on the fully amygdala-kindled seizures was investigated. Fully kindled seizures were produced by repeated application of low intensity electrical stimulation to the basolateral amygdala once per day. Fifteen consecutive stimulations were needed to reach the first stage 5 seizures at which animals showed behavioral convulsions and electroencephalographic abnormalities. The stage 5 seizures were suppressed by vanillin ip 1 h before stimulation with the ED50 of 286 mg/kg. Meanwhile, the epileptic afterdischarge duration was significantly shortened. Phenytoin at a nontoxic dose 50 mg/kg ip obviously reduced the stage 5 seizures. The present study provides a very useful experimental model of chronic epilepsy to detect anticonvulsants.
H Q Wu, and
L Xie, and
X N Jin, and
Q Ge, and
H Jin, and
G Q Liu
July 1992,
Neuroscience letters,
H Q Wu, and
L Xie, and
X N Jin, and
Q Ge, and
H Jin, and
G Q Liu
May 1991,
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques,
H Q Wu, and
L Xie, and
X N Jin, and
Q Ge, and
H Jin, and
G Q Liu
April 1989,
Brain research bulletin,
H Q Wu, and
L Xie, and
X N Jin, and
Q Ge, and
H Jin, and
G Q Liu
May 1981,
Journal of studies on alcohol,
H Q Wu, and
L Xie, and
X N Jin, and
Q Ge, and
H Jin, and
G Q Liu
March 1989,
Neurological research,
H Q Wu, and
L Xie, and
X N Jin, and
Q Ge, and
H Jin, and
G Q Liu
February 1982,
Neuropharmacology,
H Q Wu, and
L Xie, and
X N Jin, and
Q Ge, and
H Jin, and
G Q Liu
January 2001,
Polish journal of pharmacology,
H Q Wu, and
L Xie, and
X N Jin, and
Q Ge, and
H Jin, and
G Q Liu
June 1986,
Experimental neurology,
H Q Wu, and
L Xie, and
X N Jin, and
Q Ge, and
H Jin, and
G Q Liu
January 2006,
Canadian journal of physiology and pharmacology,
H Q Wu, and
L Xie, and
X N Jin, and
Q Ge, and
H Jin, and
G Q Liu
February 1992,
Acta neurologica Scandinavica,
