Biomaterial Database

Protective role of ascorbic acid in hemorrhage-induced cardiovascular depression. 2014

Bharti Bhandari, and Sangeeta K Kohli, and Vanita Lal

Haemorrhagic shock is associated with hyperproduction of free radicals. Hence ascorbic acid (AA), a free radical scavenger, may be of benefit in such cases. We investigated in Wistar rats the role of free radicals in causing cardiovascular depression and the protective role of ascorbic acid, if any, in acute haemorrhage. The rats were catheterized for recording hemodynamic parameters. Acute haemorrhage was induced through phlebotomy followed by resuscitation. The test group received AA for 3 days before inducing haemorrhage and was resuscitated with AA and Ringer's lactate. The controls received only ringer lactate. Malondialdehyde was estimated to assess free-radical production. All rats showed significant fall in cardiovascular parameters with simultaneous increase in MDA level. While all rats showed significant improvement following resuscitation, the recovery was greater in the test group. The MDA levels decreased significantly in the ascorbic acid treated group. Our results demonstrate the involvement of free radicals in hemorrhage-induced cardiovascular depression and the cardio-protective effect of ascorbic acid.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008315	Malondialdehyde	The dialdehyde of malonic acid.	Malonaldehyde,Propanedial,Malonylaldehyde,Malonyldialdehyde,Sodium Malondialdehyde,Malondialdehyde, Sodium
D005260	Female		Females
D005609	Free Radicals	Highly reactive molecules with an unsatisfied electron valence pair. Free radicals are produced in both normal and pathological processes. Free radicals include reactive oxygen and nitrogen species (RONS). They are proven or suspected agents of tissue damage in a wide variety of circumstances including radiation, damage from environment chemicals, and aging. Natural and pharmacological prevention of free radical damage is being actively investigated.	Free Radical
D006439	Hemodynamics	The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.	Hemodynamic
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001205	Ascorbic Acid	A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.	Vitamin C,Ascorbic Acid, Monosodium Salt,Ferrous Ascorbate,Hybrin,L-Ascorbic Acid,Magnesium Ascorbate,Magnesium Ascorbicum,Magnesium di-L-Ascorbate,Magnorbin,Sodium Ascorbate,Acid, Ascorbic,Acid, L-Ascorbic,Ascorbate, Ferrous,Ascorbate, Magnesium,Ascorbate, Sodium,L Ascorbic Acid,Magnesium di L Ascorbate,di-L-Ascorbate, Magnesium
D012771	Shock, Hemorrhagic	Acute hemorrhage or excessive fluid loss resulting in HYPOVOLEMIA.	Hemorrhagic Shock
D017208	Rats, Wistar	A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.	Wistar Rat,Rat, Wistar,Wistar Rats
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus