Biomaterial Database

Comparison of interlaboratory results for blood lead with results from a definitive method. 1979

J Boone, and T Hearn, and S Lewis

Results reported by 113 participants in the Blood Lead Proficiency Testing Program conducted by the Center for Disease Control were compared with those obtained by the National Bureau of Standards (NBS) with a definitive methods (mass spectroscopy-isotopic dilution) for blood lead analyses. Data were compiled from the results obtained for 12 whole-blood samples containing 1.5 g of disodium EDTA per liter. Twelve separate blood samples were obtained from cattle which had been given lead nitrate orally. Lead concentrations in the samples ranged from 0.628 to 4.93 mumol/L (130-1020 micrograms/L) as determined by NBS. The methods used by laboratories were classified according to six basic groups: anodic stripping voltametry; and atomic absorption spectroscopy in which either extraction, carbon rod, graphite furnace, tantalum strip, or Delves cup was used. For results obtained in each group a linear regression analyses of laboratory values was made on the basis of NBS values. In comparison to the definitive method, most field methods for blood lead tended to overestimate the lead concentration when the actual lead concentration was less than 1.96 mumol/L (400 micrograms/L) and to underestimate the lead concentration when the actual lead concentration was greater than 2.45 mumol/L (500 micrograms/L).

UI	MeSH Term	Description	Entries
D007854	Lead	A soft, grayish metal with poisonous salts; atomic number 82, atomic weight 207.2, symbol Pb.
D007855	Lead Poisoning	Poisoning that results from chronic or acute ingestion, injection, inhalation, or skin absorption of LEAD or lead compounds.	Poisoning, Lead,Lead Poisonings,Poisonings, Lead
D011786	Quality Control	A system for verifying and maintaining a desired level of quality in a product or process by careful planning, use of proper equipment, continued inspection, and corrective action as required. (Random House Unabridged Dictionary, 2d ed)	Control, Quality,Controls, Quality,Quality Controls
D012015	Reference Standards	A basis of value established for the measure of quantity, weight, extent or quality, e.g. weight standards, standard solutions, methods, techniques, and procedures used in diagnosis and therapy.	Standard Preparations,Standards, Reference,Preparations, Standard,Standardization,Standards,Preparation, Standard,Reference Standard,Standard Preparation,Standard, Reference
D012044	Regression Analysis	Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.	Regression Diagnostics,Statistical Regression,Analysis, Regression,Analyses, Regression,Diagnostics, Regression,Regression Analyses,Regression, Statistical,Regressions, Statistical,Statistical Regressions
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D013058	Mass Spectrometry	An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.	Mass Spectroscopy,Spectrometry, Mass,Spectroscopy, Mass,Spectrum Analysis, Mass,Analysis, Mass Spectrum,Mass Spectrum Analysis,Analyses, Mass Spectrum,Mass Spectrum Analyses,Spectrum Analyses, Mass