BIOMAT Database Logo BIOMAT Database Logo

[Production of fibronectin and PGE2 by cultured human alveolar macrophages]. 1989

H Moriguchi, and T Ozaki, and S Yasuoka, and T Ogura

Production of fibronectin (Fn) and prostaglandin E2 (PGE2) by human alveolar macrophages (AM) which were obtained by bronchoalveolar lavage was studied in vitro. AM obtained from patients with idiopathic interstitial pneumonia (IIP) produced much more Fn than those from normal volunteers but produced less amounts of PGE2. We also tested the effect of lipopolysaccharide (LPS), phorbol 12-myristate 13-acetate (PMA), zymosan and albumin-anti albumin complex (alb-anti alb) on production of Fn and PGE2 from AM. LPS, PMA and zymosan suppressed Fn production but stimulated PGE2 production by AM from patients with IIP but indomethacin reversed the suppressive effect of LPS, PMA and zymosan on Fn production. On the contrary, alb-anti alb stimulated Fn production by AM. Furthermore, exogenous PGE2 suppressed Fn production by AM from patients with IIP in a dose-dependent manner. These data suggest that Fn production by AM may be changed by different stimuli or different states of disease, and there is close relationship between the production of Fn and PGE2 by AM.

UI MeSH Term Description Entries
D008264 Macrophages The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.) Bone Marrow-Derived Macrophages,Monocyte-Derived Macrophages,Macrophage,Macrophages, Monocyte-Derived,Bone Marrow Derived Macrophages,Bone Marrow-Derived Macrophage,Macrophage, Bone Marrow-Derived,Macrophage, Monocyte-Derived,Macrophages, Bone Marrow-Derived,Macrophages, Monocyte Derived,Monocyte Derived Macrophages,Monocyte-Derived Macrophage
D011650 Pulmonary Alveoli Small polyhedral outpouchings along the walls of the alveolar sacs, alveolar ducts and terminal bronchioles through the walls of which gas exchange between alveolar air and pulmonary capillary blood takes place. Alveoli, Pulmonary,Alveolus, Pulmonary,Pulmonary Alveolus
D011658 Pulmonary Fibrosis A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death. Alveolitis, Fibrosing,Idiopathic Diffuse Interstitial Pulmonary Fibrosis,Fibroses, Pulmonary,Fibrosis, Pulmonary,Pulmonary Fibroses,Alveolitides, Fibrosing,Fibrosing Alveolitides,Fibrosing Alveolitis
D005353 Fibronectins Glycoproteins found on the surfaces of cells, particularly in fibrillar structures. The proteins are lost or reduced when these cells undergo viral or chemical transformation. They are highly susceptible to proteolysis and are substrates for activated blood coagulation factor VIII. The forms present in plasma are called cold-insoluble globulins. Cold-Insoluble Globulins,LETS Proteins,Fibronectin,Opsonic Glycoprotein,Opsonic alpha(2)SB Glycoprotein,alpha 2-Surface Binding Glycoprotein,Cold Insoluble Globulins,Globulins, Cold-Insoluble,Glycoprotein, Opsonic,Proteins, LETS,alpha 2 Surface Binding Glycoprotein
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D015232 Dinoprostone The most common and most biologically active of the mammalian prostaglandins. It exhibits most biological activities characteristic of prostaglandins and has been used extensively as an oxytocic agent. The compound also displays a protective effect on the intestinal mucosa. PGE2,PGE2alpha,Prostaglandin E2,Prostaglandin E2alpha,PGE2 alpha,Prepidil Gel,Prostaglandin E2 alpha,Prostenon,E2 alpha, Prostaglandin,E2, Prostaglandin,E2alpha, Prostaglandin,Gel, Prepidil,alpha, PGE2,alpha, Prostaglandin E2

Related Publications

H Moriguchi, and T Ozaki, and S Yasuoka, and T Ogura
Adhesion to fibronectin augments tumor necrosis factor production by human alveolar macrophages.
March 1994, Chest,
H Moriguchi, and T Ozaki, and S Yasuoka, and T Ogura
Production and secretion of adrenomedullin in cultured human alveolar macrophages.
January 1999, Peptides,
H Moriguchi, and T Ozaki, and S Yasuoka, and T Ogura
Production of chemotactic factor(s) by in vivo cultured human alveolar macrophages.
February 1979, Chest,
H Moriguchi, and T Ozaki, and S Yasuoka, and T Ogura
Spontaneous production of fibronectin by alveolar macrophages in patients with scleroderma.
May 1989, Arthritis and rheumatism,
H Moriguchi, and T Ozaki, and S Yasuoka, and T Ogura
Production of C2 by human alveolar macrophages.
August 1978, Immunology,
H Moriguchi, and T Ozaki, and S Yasuoka, and T Ogura
PGE2 and TXA2 production by isolated macrophages from human placenta.
January 1997, Advances in experimental medicine and biology,
H Moriguchi, and T Ozaki, and S Yasuoka, and T Ogura
Opsonin-independent phagocytosis by human alveolar macrophages: augmentation by human plasma fibronectin.
May 1982, The American review of respiratory disease,
H Moriguchi, and T Ozaki, and S Yasuoka, and T Ogura
Fibronectin production by cultured human trabecular meshwork cells.
August 1982, Investigative ophthalmology & visual science,
H Moriguchi, and T Ozaki, and S Yasuoka, and T Ogura
Lipocortin I production by human alveolar macrophages.
January 1992, American journal of respiratory cell and molecular biology,
H Moriguchi, and T Ozaki, and S Yasuoka, and T Ogura
Interleukin-4 production by human alveolar macrophages.
June 2005, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology,
Copied contents to your clipboard!