Trapping drug efficiency in liposomes produced by extrusion of freeze-thaw multilamellar vesicles.
1989
S F Aliño, and
M García, and
M Lejarreta, and
M Bobadilla, and
G Pérez-Yarza, and
F J Unda
Departamento de Biología Celular y Ciencias Morfológicas, Facultad de Medicina y Odontologia, Universidad del Pais Vasco/Euskal Herriko Unibertsitatea, Leioa, Spain.
UI
MeSH Term
Description
Entries
D008081
Liposomes
Artificial, single or multilaminar vesicles (made from lecithins or other lipids) that are used for the delivery of a variety of biological molecules or molecular complexes to cells, for example, drug delivery and gene transfer. They are also used to study membranes and membrane proteins.
Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.
Drug Carrier
D005452
Fluoresceins
A family of spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one derivatives. These are used as dyes, as indicators for various metals, and as fluorescent labels in immunoassays.
Tetraiodofluorescein
D005615
Freezing
Liquids transforming into solids by the removal of heat.
Melting
Related Publications
S F Aliño, and
M García, and
M Lejarreta, and
M Bobadilla, and
G Pérez-Yarza, and
F J Unda