BIOMAT Database Logo BIOMAT Database Logo

Developmental exposure to T-2 toxin reversibly affects postnatal hippocampal neurogenesis and reduces neural stem cells and progenitor cells in mice. 2016

Takeshi Tanaka, and Hajime Abe, and Masayuki Kimura, and Nobuhiko Onda, and Sayaka Mizukami, and Toshinori Yoshida, and Makoto Shibutani
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan.

To determine the developmental exposure effects of T-2 toxin on postnatal hippocampal neurogenesis, pregnant ICR mice were provided a diet containing T-2 toxin at 0, 1, 3, or 9 ppm from gestation day 6 to day 21 on weaning after delivery. Offspring were maintained through postnatal day (PND) 77 without T-2 toxin exposure. In the hippocampal dentate gyrus of male PND 21 offspring, GFAP(+) and BLBP(+) type-1 stem cells and PAX6(+) and TBR2(+) type-2 progenitor cells decreased in the subgranular zone (SGZ) at 9 and ≥3 ppm, respectively, in parallel with increased apoptosis at ≥3 ppm. In the dentate hilus, reelin(+) γ-aminobutyric acid (GABA)-ergic interneurons increased at 9 ppm, suggesting reflection of neuronal mismigration. T-2 toxin decreased transcript levels of cholinergic and glutamate receptor subunits (Chrna4, Chrnb2 and Gria2) and glutamate transporter (Slc17a6) in the dentate gyrus, suggesting decreased cholinergic signals on hilar GABAergic interneurons innervating type-2 cells and decreased glutamatergic signals on type-1 and type-2 cells. T-2 toxin decreased SGZ cells expressing stem cell factor (SCF) and increased cells accumulating malondialdehydes. Neurogenesis-related changes disappeared on PND 77, suggesting that T-2 toxin reversibly affects neurogenesis by inducing apoptosis of type-1 and type-2 cells with different threshold levels. Decreased cholinergic and glutamatergic signals may decrease type-2 cells at ≥3 ppm. Additionally, decreased SCF/c-Kit interactions and increased oxidative stress may decrease type-1 and type-2 cells at 9 ppm. The no-observed-adverse-effect level for offspring neurogenesis was determined to be 1 ppm (0.14-0.49 mg/kg body weight/day).

UI MeSH Term Description Entries
D008297 Male Males
D008813 Mice, Inbred ICR An inbred strain of mouse that is used as a general purpose research strain, for therapeutic drug testing, and for the genetic analysis of CARCINOGEN-induced COLON CANCER. Mice, Inbred ICRC,Mice, ICR,Mouse, ICR,Mouse, Inbred ICR,Mouse, Inbred ICRC,ICR Mice,ICR Mice, Inbred,ICR Mouse,ICR Mouse, Inbred,ICRC Mice, Inbred,ICRC Mouse, Inbred,Inbred ICR Mice,Inbred ICR Mouse,Inbred ICRC Mice,Inbred ICRC Mouse
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D011297 Prenatal Exposure Delayed Effects The consequences of exposing the FETUS in utero to certain factors, such as NUTRITION PHYSIOLOGICAL PHENOMENA; PHYSIOLOGICAL STRESS; DRUGS; RADIATION; and other physical or chemical factors. These consequences are observed later in the offspring after BIRTH. Delayed Effects, Prenatal Exposure,Late Effects, Prenatal Exposure
D011950 Receptors, Cholinergic Cell surface proteins that bind acetylcholine with high affinity and trigger intracellular changes influencing the behavior of cells. Cholinergic receptors are divided into two major classes, muscarinic and nicotinic, based originally on their affinity for nicotine and muscarine. Each group is further subdivided based on pharmacology, location, mode of action, and/or molecular biology. ACh Receptor,Acetylcholine Receptor,Acetylcholine Receptors,Cholinergic Receptor,Cholinergic Receptors,Cholinoceptive Sites,Cholinoceptor,Cholinoceptors,Receptors, Acetylcholine,ACh Receptors,Receptors, ACh,Receptor, ACh,Receptor, Acetylcholine,Receptor, Cholinergic,Sites, Cholinoceptive
D005260 Female Females
D005865 Gestational Age The age of the conceptus, beginning from the time of FERTILIZATION. In clinical obstetrics, the gestational age is often estimated from the onset of the last MENSTRUATION which is about 2 weeks before OVULATION and fertilization. It is also estimated to begin from fertilization, estrus, coitus, or artificial insemination. Embryologic Age,Fetal Maturity, Chronologic,Chronologic Fetal Maturity,Fetal Age,Maturity, Chronologic Fetal,Age, Embryologic,Age, Fetal,Age, Gestational,Ages, Embryologic,Ages, Fetal,Ages, Gestational,Embryologic Ages,Fetal Ages,Gestational Ages
D006624 Hippocampus A curved elevation of GRAY MATTER extending the entire length of the floor of the TEMPORAL HORN of the LATERAL VENTRICLE (see also TEMPORAL LOBE). The hippocampus proper, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation. Ammon Horn,Cornu Ammonis,Hippocampal Formation,Subiculum,Ammon's Horn,Hippocampus Proper,Ammons Horn,Formation, Hippocampal,Formations, Hippocampal,Hippocampal Formations,Hippocampus Propers,Horn, Ammon,Horn, Ammon's,Proper, Hippocampus,Propers, Hippocampus,Subiculums
D000091042 Reelin Protein It is an EXTRACELLULAR MATRIX serine protease that plays an important role in the development of the central nervous system. It regulates neuronal migration and microtubule function. RELN Protein,Reeler Protein,Protein, RELN,Protein, Reeler,Protein, Reelin
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

Related Publications

Takeshi Tanaka, and Hajime Abe, and Masayuki Kimura, and Nobuhiko Onda, and Sayaka Mizukami, and Toshinori Yoshida, and Makoto Shibutani
Developmental Exposure of Mice to T-2 Toxin Increases Astrocytes and Hippocampal Neural Stem Cells Expressing Metallothionein.
April 2019, Neurotoxicity research,
Takeshi Tanaka, and Hajime Abe, and Masayuki Kimura, and Nobuhiko Onda, and Sayaka Mizukami, and Toshinori Yoshida, and Makoto Shibutani
Developmental exposure of aflatoxin B1 reversibly affects hippocampal neurogenesis targeting late-stage neural progenitor cells through suppression of cholinergic signaling in rats.
October 2015, Toxicology,
Takeshi Tanaka, and Hajime Abe, and Masayuki Kimura, and Nobuhiko Onda, and Sayaka Mizukami, and Toshinori Yoshida, and Makoto Shibutani
Developmental Exposure to Aluminum Chloride Irreversibly Affects Postnatal Hippocampal Neurogenesis Involving Multiple Functions in Mice.
July 2018, Toxicological sciences : an official journal of the Society of Toxicology,
Takeshi Tanaka, and Hajime Abe, and Masayuki Kimura, and Nobuhiko Onda, and Sayaka Mizukami, and Toshinori Yoshida, and Makoto Shibutani
Single alcohol exposure in early life damages hippocampal stem/progenitor cells and reduces adult neurogenesis.
June 2007, Neurobiology of disease,
Takeshi Tanaka, and Hajime Abe, and Masayuki Kimura, and Nobuhiko Onda, and Sayaka Mizukami, and Toshinori Yoshida, and Makoto Shibutani
Genome integrity and neurogenesis of postnatal hippocampal neural stem/progenitor cells require a unique regulator Filia.
October 2020, Science advances,
Takeshi Tanaka, and Hajime Abe, and Masayuki Kimura, and Nobuhiko Onda, and Sayaka Mizukami, and Toshinori Yoshida, and Makoto Shibutani
Capsaicin impairs proliferation of neural progenitor cells and hippocampal neurogenesis in young mice.
January 2010, Journal of toxicology and environmental health. Part A,
Takeshi Tanaka, and Hajime Abe, and Masayuki Kimura, and Nobuhiko Onda, and Sayaka Mizukami, and Toshinori Yoshida, and Makoto Shibutani
Developmental exposure of citreoviridin transiently affects hippocampal neurogenesis targeting multiple regulatory functions in mice.
October 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
Takeshi Tanaka, and Hajime Abe, and Masayuki Kimura, and Nobuhiko Onda, and Sayaka Mizukami, and Toshinori Yoshida, and Makoto Shibutani
Oral exposure to high-dose ethanol for 28 days in rats reduces neural stem cells and immediate nascent neural progenitor cells as well as FOS-expressing newborn granule cells in adult hippocampal neurogenesis.
May 2022, Toxicology letters,
Takeshi Tanaka, and Hajime Abe, and Masayuki Kimura, and Nobuhiko Onda, and Sayaka Mizukami, and Toshinori Yoshida, and Makoto Shibutani
Pten deletion in adult hippocampal neural stem/progenitor cells causes cellular abnormalities and alters neurogenesis.
April 2012, The Journal of neuroscience : the official journal of the Society for Neuroscience,
Takeshi Tanaka, and Hajime Abe, and Masayuki Kimura, and Nobuhiko Onda, and Sayaka Mizukami, and Toshinori Yoshida, and Makoto Shibutani
Complement receptor 2 is expressed in neural progenitor cells and regulates adult hippocampal neurogenesis.
March 2011, The Journal of neuroscience : the official journal of the Society for Neuroscience,
Copied contents to your clipboard!