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Following a single intraperitoneal injection of oxonic acid, urate-oxidase inhibitor with optical and chromatographic properties of the injected drug was found in the supernatants of mouse liver homogenates. Maximal inhibitory activity of 40 000 g-20 minutes supernatants against Sigma urate-oxidase was found 30 minutes after injection, and it almost disappeared after six hours. In whole homogenates, urate-oxidase activity was found 50% inhibited at 30 minutes, and it returned to normal levels between 3 and 6 hours following injection. Urate-oxidase activity of resuspended nuclei-free 40 000 g particles from these homogenates showed a significative increase of activity over controls during the first three hours after injection, and it returned to a normal level between 3 and 6 hours after injection. There was, instead, no increase of activity in 40 000 g-20 minutes particles suspensions when these were separated from homogenates prepared from untreated mice and incubated with oxonic acid.
M E Otta, and
F Bertini
July 1973,
Histochemie. Histochemistry. Histochimie,
M E Otta, and
F Bertini
November 2012,
FEBS letters,
M E Otta, and
F Bertini
January 1994,
Proceedings of the National Academy of Sciences of the United States of America,
M E Otta, and
F Bertini
January 1976,
Toxicology,
M E Otta, and
F Bertini
October 1973,
Histochemie. Histochemistry. Histochimie,
M E Otta, and
F Bertini
September 1991,
Journal of cellular biochemistry,
M E Otta, and
F Bertini
January 1994,
Advances in experimental medicine and biology,
M E Otta, and
F Bertini
May 1974,
Histochemistry,
M E Otta, and
F Bertini
May 1997,
Transplantation,
M E Otta, and
F Bertini
November 1984,
Presse medicale (Paris, France : 1983),
