BIOMAT Database Logo BIOMAT Database Logo

Hypertonic Saline Dextran Ameliorates Organ Damage in Beagle Hemorrhagic Shock. 2015

Jing-xiang Zhao, and Bo Wang, and Guo-xing You, and Ying Wang, and Gan Chen, and Quan Wang, and Xi-gang Zhang, and Lian Zhao, and Hong Zhou, and Yue-zhong He
Institute of Transfusion Medicine, Academy of Military Medical Sciences, No. 27th Taiping Road, HaiDian, Beijing, China.

OBJECTIVE The goal of this study was to investigate the effect of hypertonic saline with 6% Dextran-70 (HSD) resuscitation on organ damage and the resuscitation efficiency of the combination of HSD and lactated ringers (LR) in a model of hemorrhage shock in dogs. METHODS Beagles were bled to hold their mean arterial pressure (MAP) at 50 ± 5 mmHg for 1 h. After hemorrhage, beagles were divided into three groups (n = 7) to receive pre-hospital resuscitation for 1 h (R1): HSD (4 ml/kg), LR (40 ml/kg), and HSD+LR (a combination of 4 ml/kg HSD and 40 ml/kg LR). Next, LR was transfused into all groups as in-hospital resuscitation (R2). After two hours of observation (R3), autologous blood was transfused. Hemodynamic responses and systemic oxygenation were measured at predetermined phases. Three days after resuscitation, the animals were sacrificed and tissues including kidney, lung, liver and intestinal were obtained for pathological analysis. RESULTS Although the initial resuscitation with HSD was shown to be faster than LR with regard to an ascending MAP, the HSD group showed a similar hemodynamic performance compared to the LR group throughout the experiment. Compared with the LR group, the systemic oxygenation performance in the HSD group was similar but showed a lower venous-to-arterial CO2 gradient (Pv-aCO2) at R3 (p < 0.05). Additionally, the histology score of the kidneys, lungs and liver were significantly lower in the HSD group than in the LR group (p < 0.05). The HSD+LR group showed a superior hemodynamic response but higher extravascular lung water (EVLW) and lower arterial oxygen tension (PaO2) than the other groups (p < 0.05). The HSD+LR group showed a marginally improved systemic oxygenation performance and lower histology score than other groups. CONCLUSIONS Resuscitation after hemorrhagic shock with a bolus of HSD showed a similar hemodynamic response compared with LR at ten times the volume of HSD, but HSD showed superior efficacy in organ protection. Our findings suggest that resuscitation with the combination of HSD and LR in the pre-hospital setting is an effective treatment.

UI MeSH Term Description Entries
D008297 Male Males
D009102 Multiple Organ Failure A progressive condition usually characterized by combined failure of several organs such as the lungs, liver, kidney, along with some clotting mechanisms, usually postinjury or postoperative. MODS,Multiple Organ Dysfunction Syndrome,Organ Dysfunction Syndrome, Multiple,Organ Failure, Multiple,Failure, Multiple Organ,Multiple Organ Failures
D003911 Dextrans A group of glucose polymers made by certain bacteria. Dextrans are used therapeutically as plasma volume expanders and anticoagulants. They are also commonly used in biological experimentation and in industry for a wide variety of purposes. Dextran,Dextran 40,Dextran 40000,Dextran 70,Dextran 75,Dextran 80,Dextran B-1355,Dextran B-1355-S,Dextran B1355,Dextran B512,Dextran Derivatives,Dextran M 70,Dextran T 70,Dextran T-40,Dextran T-500,Hemodex,Hyskon,Infukoll,Macrodex,Polyglucin,Promit,Rheodextran,Rheoisodex,Rheomacrodex,Rheopolyglucin,Rondex,Saviosol,Dextran B 1355,Dextran B 1355 S,Dextran T 40,Dextran T 500
D004285 Dogs The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065) Canis familiaris,Dog
D006439 Hemodynamics The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM. Hemodynamic
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012462 Saline Solution, Hypertonic Hypertonic sodium chloride solution. A solution having an osmotic pressure greater than that of physiologic salt solution (0.9 g NaCl in 100 ml purified water). Hypertonic Saline Solution,Hypertonic Solution, Saline,Sodium Chloride Solution, Hypertonic,Hypertonic Saline Solutions,Hypertonic Solutions, Saline,Saline Solutions, Hypertonic,Sodium Chloride Solutions, Hypertonic,Saline Hypertonic Solution,Saline Hypertonic Solutions,Solution, Hypertonic Saline,Solution, Saline Hypertonic,Solutions, Hypertonic Saline,Solutions, Saline Hypertonic
D012771 Shock, Hemorrhagic Acute hemorrhage or excessive fluid loss resulting in HYPOVOLEMIA. Hemorrhagic Shock

Related Publications

Jing-xiang Zhao, and Bo Wang, and Guo-xing You, and Ying Wang, and Gan Chen, and Quan Wang, and Xi-gang Zhang, and Lian Zhao, and Hong Zhou, and Yue-zhong He
Hypertonic saline-dextran resuscitation from hemorrhagic shock induces transient mixed acidosis.
February 1995, Critical care medicine,
Jing-xiang Zhao, and Bo Wang, and Guo-xing You, and Ying Wang, and Gan Chen, and Quan Wang, and Xi-gang Zhang, and Lian Zhao, and Hong Zhou, and Yue-zhong He
Resuscitation from hemorrhagic shock: experimental model comparing normal saline, dextran, and hypertonic saline solutions.
July 2003, Critical care medicine,
Jing-xiang Zhao, and Bo Wang, and Guo-xing You, and Ying Wang, and Gan Chen, and Quan Wang, and Xi-gang Zhang, and Lian Zhao, and Hong Zhou, and Yue-zhong He
Melatonin ameliorates hemorrhagic shock-induced organ damage in rats.
May 2011, The Journal of surgical research,
Jing-xiang Zhao, and Bo Wang, and Guo-xing You, and Ying Wang, and Gan Chen, and Quan Wang, and Xi-gang Zhang, and Lian Zhao, and Hong Zhou, and Yue-zhong He
Effects of hypertonic saline and dextran 70 on cardiac contractility after hemorrhagic shock.
January 1998, The Journal of trauma,
Jing-xiang Zhao, and Bo Wang, and Guo-xing You, and Ying Wang, and Gan Chen, and Quan Wang, and Xi-gang Zhang, and Lian Zhao, and Hong Zhou, and Yue-zhong He
Treatment of dogs in hemorrhagic shock by intraosseous infusion of hypertonic saline and dextran.
January 1992, Veterinary surgery : VS,
Jing-xiang Zhao, and Bo Wang, and Guo-xing You, and Ying Wang, and Gan Chen, and Quan Wang, and Xi-gang Zhang, and Lian Zhao, and Hong Zhou, and Yue-zhong He
Hypertonic saline dextran attenuates leukocyte accumulation in the liver after hemorrhagic shock and resuscitation.
March 1999, The Journal of trauma,
Jing-xiang Zhao, and Bo Wang, and Guo-xing You, and Ying Wang, and Gan Chen, and Quan Wang, and Xi-gang Zhang, and Lian Zhao, and Hong Zhou, and Yue-zhong He
Treatment of hemorrhagic shock with intraosseous or intravenous infusion of hypertonic saline dextran solution.
January 1991, European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes,
Jing-xiang Zhao, and Bo Wang, and Guo-xing You, and Ying Wang, and Gan Chen, and Quan Wang, and Xi-gang Zhang, and Lian Zhao, and Hong Zhou, and Yue-zhong He
Effects of hypertonic saline and dextran 70 on cardiac diastolic function after hemorrhagic shock.
September 2002, The Journal of surgical research,
Jing-xiang Zhao, and Bo Wang, and Guo-xing You, and Ying Wang, and Gan Chen, and Quan Wang, and Xi-gang Zhang, and Lian Zhao, and Hong Zhou, and Yue-zhong He
Hypertonic saline solution resuscitation in hemorrhagic shock dogs.
June 2002, Chinese journal of traumatology = Zhonghua chuang shang za zhi,
Jing-xiang Zhao, and Bo Wang, and Guo-xing You, and Ying Wang, and Gan Chen, and Quan Wang, and Xi-gang Zhang, and Lian Zhao, and Hong Zhou, and Yue-zhong He
Immunomodulatory effect of hypertonic saline in hemorrhagic shock.
October 2015, Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences,
Copied contents to your clipboard!