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Synthesis of new kojic acid based unnatural α-amino acid derivatives. 2015

C Balakrishna, and Nagaraju Payili, and Satyanarayana Yennam, and P Uma Devi, and Manoranjan Behera
Medicinal Chemistry Department, GVK Biosciences Pvt. Ltd, Survey Nos: 125 (Part) & 126, IDA, Mallapur, Hyderabad 500076, Telangana, India; Department of Chemistry, GITAM Institute of Science, GITAM University, Rushikonda, Visakhapatnam 530045, AP, India.

An efficient method for the preparation of kojic acid based α-amino acid derivatives by alkylation of glycinate schiff base with bromokojic acids have been described. Using this method, mono as well as di alkylated kojic acid-amino acid conjugates have been prepared. This is the first synthesis of C-linked kojic acid-amino acid conjugate where kojic acid is directly linked to amino acid through a C-C bond.

UI MeSH Term Description Entries
D011753 Pyrones Keto-pyrans.
D000596 Amino Acids Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins. Amino Acid,Acid, Amino,Acids, Amino
D015394 Molecular Structure The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds. Structure, Molecular,Molecular Structures,Structures, Molecular

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