Current concepts on hemodynamic support and therapy in septic shock. 2015

Leonardo Lima Rocha, and Camila Menezes Souza Pessoa, and Thiago Domingos Corrêa, and Adriano José Pereira, and Murillo Santucci Cesar de Assunção, and Eliézer Silva
Intensive Care Unit, Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.

Severe sepsis and septic shock represent a major healthcare challenge. Much of the improvement in mortality associated with septic shock is related to early recognition combined with timely fluid resuscitation and adequate antibiotics administration. The main goals of septic shock resuscitation include intravascular replenishment, maintenance of adequate perfusion pressure and oxygen delivery to tissues. To achieve those goals, fluid responsiveness evaluation and complementary interventions - i.e. vasopressors, inotropes and blood transfusion - may be necessary. This article is a literature review of the available evidence on the initial hemodynamic support of the septic shock patients presenting to the emergency room or to the intensive care unit and the main interventions available to reach those targets, focusing on fluid and vasopressor therapy, blood transfusion and inotrope administration.

UI MeSH Term Description Entries
D010100 Oxygen An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration. Dioxygen,Oxygen-16,Oxygen 16
D012151 Resuscitation The restoration to life or consciousness of one apparently dead. (Dorland, 27th ed) Resuscitations
D001803 Blood Transfusion The introduction of whole blood or blood component directly into the blood stream. (Dorland, 27th ed) Blood Transfusions,Transfusion, Blood,Transfusions, Blood
D002496 Central Venous Pressure The blood pressure in the central large VEINS of the body. It is distinguished from peripheral venous pressure which occurs in an extremity. Venous Pressure, Central,Central Venous Pressures,Pressure, Central Venous,Pressures, Central Venous,Venous Pressures, Central
D005440 Fluid Therapy Therapy whose basic objective is to restore the volume and composition of the body fluids to normal with respect to WATER-ELECTROLYTE BALANCE. Fluids may be administered intravenously, orally, by intermittent gavage, or by HYPODERMOCLYSIS. Oral Rehydration Therapy,Rehydration,Rehydration, Oral,Oral Rehydration,Rehydration Therapy, Oral,Therapy, Fluid,Therapy, Oral Rehydration,Fluid Therapies,Oral Rehydration Therapies,Oral Rehydrations,Rehydration Therapies, Oral,Rehydrations,Rehydrations, Oral,Therapies, Fluid,Therapies, Oral Rehydration
D006439 Hemodynamics The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM. Hemodynamic
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012772 Shock, Septic Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status. Endotoxin Shock,Septic Shock,Shock, Endotoxic,Shock, Toxic,Toxic Shock,Toxic Shock Syndrome,Endotoxin Shocks,Shock Syndrome, Toxic,Shock, Endotoxin,Shocks, Endotoxin,Toxic Shock Syndromes
D062186 Arterial Pressure The blood pressure in the ARTERIES. It is commonly measured with a SPHYGMOMANOMETER on the upper arm which represents the arterial pressure in the BRACHIAL ARTERY. Aortic Blood Pressure,Aortic Pressure,Aortic Pulse Pressure,Aortic Tension,Arterial Blood Pressure,Arterial Tension,Blood Pressure, Aortic,Blood Pressure, Arterial,Mean Aortic Pressure,Mean Arterial Pressure,Aortic Blood Pressures,Aortic Pressure, Mean,Aortic Pressures,Aortic Pressures, Mean,Aortic Pulse Pressures,Aortic Tensions,Arterial Blood Pressures,Arterial Pressure, Mean,Arterial Pressures,Arterial Pressures, Mean,Arterial Tensions,Blood Pressures, Aortic,Blood Pressures, Arterial,Mean Aortic Pressures,Mean Arterial Pressures,Pressure, Aortic,Pressure, Aortic Blood,Pressure, Aortic Pulse,Pressure, Arterial,Pressure, Arterial Blood,Pressure, Mean Aortic,Pressure, Mean Arterial,Pressures, Aortic,Pressures, Aortic Blood,Pressures, Aortic Pulse,Pressures, Arterial,Pressures, Arterial Blood,Pressures, Mean Aortic,Pressures, Mean Arterial,Pulse Pressure, Aortic,Pulse Pressures, Aortic,Tension, Aortic,Tension, Arterial,Tensions, Aortic,Tensions, Arterial
D019344 Lactic Acid A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed) Lactate,2-Hydroxypropanoic Acid,2-Hydroxypropionic Acid,Ammonium Lactate,D-Lactic Acid,L-Lactic Acid,Propanoic Acid, 2-Hydroxy-, (2R)-,Propanoic Acid, 2-Hydroxy-, (2S)-,Sarcolactic Acid,2 Hydroxypropanoic Acid,2 Hydroxypropionic Acid,D Lactic Acid,L Lactic Acid,Lactate, Ammonium

Related Publications

Leonardo Lima Rocha, and Camila Menezes Souza Pessoa, and Thiago Domingos Corrêa, and Adriano José Pereira, and Murillo Santucci Cesar de Assunção, and Eliézer Silva
April 2021, Current opinion in anaesthesiology,
Leonardo Lima Rocha, and Camila Menezes Souza Pessoa, and Thiago Domingos Corrêa, and Adriano José Pereira, and Murillo Santucci Cesar de Assunção, and Eliézer Silva
January 2001, Intensive care medicine,
Leonardo Lima Rocha, and Camila Menezes Souza Pessoa, and Thiago Domingos Corrêa, and Adriano José Pereira, and Murillo Santucci Cesar de Assunção, and Eliézer Silva
January 1997, British journal of hospital medicine,
Leonardo Lima Rocha, and Camila Menezes Souza Pessoa, and Thiago Domingos Corrêa, and Adriano José Pereira, and Murillo Santucci Cesar de Assunção, and Eliézer Silva
September 2009, Current infectious disease reports,
Leonardo Lima Rocha, and Camila Menezes Souza Pessoa, and Thiago Domingos Corrêa, and Adriano José Pereira, and Murillo Santucci Cesar de Assunção, and Eliézer Silva
June 2010, Archivos argentinos de pediatria,
Leonardo Lima Rocha, and Camila Menezes Souza Pessoa, and Thiago Domingos Corrêa, and Adriano José Pereira, and Murillo Santucci Cesar de Assunção, and Eliézer Silva
August 1998, Pediatrics,
Leonardo Lima Rocha, and Camila Menezes Souza Pessoa, and Thiago Domingos Corrêa, and Adriano José Pereira, and Murillo Santucci Cesar de Assunção, and Eliézer Silva
February 2022, Intensive care medicine,
Leonardo Lima Rocha, and Camila Menezes Souza Pessoa, and Thiago Domingos Corrêa, and Adriano José Pereira, and Murillo Santucci Cesar de Assunção, and Eliézer Silva
March 2005, Medical science monitor : international medical journal of experimental and clinical research,
Leonardo Lima Rocha, and Camila Menezes Souza Pessoa, and Thiago Domingos Corrêa, and Adriano José Pereira, and Murillo Santucci Cesar de Assunção, and Eliézer Silva
April 2006, Medical science monitor : international medical journal of experimental and clinical research,
Leonardo Lima Rocha, and Camila Menezes Souza Pessoa, and Thiago Domingos Corrêa, and Adriano José Pereira, and Murillo Santucci Cesar de Assunção, and Eliézer Silva
March 1979, Minerva anestesiologica,
Copied contents to your clipboard!