Systematic Review and Meta-analysis of Diagnostic Accuracy of Percutaneous Renal Tumour Biopsy. 2016

Lorenzo Marconi, and Saeed Dabestani, and Thomas B Lam, and Fabian Hofmann, and Fiona Stewart, and John Norrie, and Axel Bex, and Karim Bensalah, and Steven E Canfield, and Milan Hora, and Markus A Kuczyk, and Axel S Merseburger, and Peter F A Mulders, and Thomas Powles, and Michael Staehler, and Borje Ljungberg, and Alessandro Volpe
Department of Urology, Coimbra University Hospital, Coimbra, Portugal.

BACKGROUND The role of percutaneous renal tumour biopsy (RTB) remains controversial due to uncertainties regarding its diagnostic accuracy and safety. OBJECTIVE We performed a systematic review and meta-analysis to determine the safety and accuracy of percutaneous RTB for the diagnosis of malignancy, histologic tumour subtype, and grade. METHODS Medline, Embase, and Cochrane Library were searched for studies providing data on diagnostic accuracy and complications of percutaneous core biopsy (CB) or fine-needle aspiration (FNA) of renal tumours. A meta-analysis was performed to obtain pooled estimates of sensitivity and specificity for diagnosis of malignancy. The Cohen kappa coefficient (κ) was estimated for the analysis of histotype/grade concordance between diagnosis on RTB and surgical specimen. Risk of bias assessment was performed (QUADAS-2). RESULTS A total of 57 studies recruiting 5228 patients were included. The overall median diagnostic rate of RTB was 92%. The sensitivity and specificity of diagnostic CBs and FNAs were 99.1% and 99.7%, and 93.2% and 89.8%, respectively. A good (κ = 0.683) and a fair (κ = 0.34) agreement were observed between histologic subtype and Fuhrman grade on RTB and surgical specimen, respectively. A very low rate of Clavien ≥ 2 complications was reported. Study limitations included selection and differential-verification bias. CONCLUSIONS RTB is safe and has a high diagnostic yield in experienced centres. Both CB and FNA have good accuracy for the diagnosis of malignancy and histologic subtype, with better performance for CB. The accuracy for Fuhrman grade is fair. Overall, the quality of the evidence was moderate. Prospective cohort studies recruiting consecutive patients and using homogeneous reference standards are required. RESULTS We systematically reviewed the literature to assess the safety and diagnostic performance of renal tumour biopsy (RTB). The results suggest that RTB has good accuracy in diagnosing renal cancer and its subtypes, and it appears to be safe. However, the quality of evidence was moderate, and better quality studies are required to provide a more definitive answer.

UI MeSH Term Description Entries
D007680 Kidney Neoplasms Tumors or cancers of the KIDNEY. Cancer of Kidney,Kidney Cancer,Renal Cancer,Cancer of the Kidney,Neoplasms, Kidney,Renal Neoplasms,Cancer, Kidney,Cancer, Renal,Cancers, Kidney,Cancers, Renal,Kidney Cancers,Kidney Neoplasm,Neoplasm, Kidney,Neoplasm, Renal,Neoplasms, Renal,Renal Cancers,Renal Neoplasm
D011237 Predictive Value of Tests In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test. Negative Predictive Value,Positive Predictive Value,Predictive Value Of Test,Predictive Values Of Tests,Negative Predictive Values,Positive Predictive Values,Predictive Value, Negative,Predictive Value, Positive
D002292 Carcinoma, Renal Cell A heterogeneous group of sporadic or hereditary carcinoma derived from cells of the KIDNEYS. There are several subtypes including the clear cells, the papillary, the chromophobe, the collecting duct, the spindle cells (sarcomatoid), or mixed cell-type carcinoma. Adenocarcinoma, Renal Cell,Carcinoma, Hypernephroid,Grawitz Tumor,Hypernephroma,Renal Carcinoma,Adenocarcinoma Of Kidney,Adenocarcinoma, Renal,Chromophil Renal Cell Carcinoma,Chromophobe Renal Cell Carcinoma,Clear Cell Renal Carcinoma,Clear Cell Renal Cell Carcinoma,Collecting Duct Carcinoma,Collecting Duct Carcinoma (Kidney),Collecting Duct Carcinoma of the Kidney,Nephroid Carcinoma,Papillary Renal Cell Carcinoma,Renal Cell Cancer,Renal Cell Carcinoma,Renal Cell Carcinoma, Papillary,Renal Collecting Duct Carcinoma,Sarcomatoid Renal Cell Carcinoma,Adenocarcinoma Of Kidneys,Adenocarcinomas, Renal Cell,Cancer, Renal Cell,Carcinoma, Collecting Duct,Carcinoma, Collecting Duct (Kidney),Carcinoma, Nephroid,Carcinoma, Renal,Carcinomas, Collecting Duct,Carcinomas, Collecting Duct (Kidney),Carcinomas, Renal Cell,Collecting Duct Carcinomas,Collecting Duct Carcinomas (Kidney),Hypernephroid Carcinoma,Hypernephroid Carcinomas,Hypernephromas,Kidney, Adenocarcinoma Of,Nephroid Carcinomas,Renal Adenocarcinoma,Renal Adenocarcinomas,Renal Carcinomas,Renal Cell Adenocarcinoma,Renal Cell Adenocarcinomas,Renal Cell Cancers,Renal Cell Carcinomas,Tumor, Grawitz
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D015203 Reproducibility of Results The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results. Reliability and Validity,Reliability of Result,Reproducibility Of Result,Reproducibility of Finding,Validity of Result,Validity of Results,Face Validity,Reliability (Epidemiology),Reliability of Results,Reproducibility of Findings,Test-Retest Reliability,Validity (Epidemiology),Finding Reproducibilities,Finding Reproducibility,Of Result, Reproducibility,Of Results, Reproducibility,Reliabilities, Test-Retest,Reliability, Test-Retest,Result Reliabilities,Result Reliability,Result Validities,Result Validity,Result, Reproducibility Of,Results, Reproducibility Of,Test Retest Reliability,Validity and Reliability,Validity, Face
D015588 Observer Variation The failure by the observer to measure or identify a phenomenon accurately, which results in an error. Sources for this may be due to the observer's missing an abnormality, or to faulty technique resulting in incorrect test measurement, or to misinterpretation of the data. Two varieties are inter-observer variation (the amount observers vary from one another when reporting on the same material) and intra-observer variation (the amount one observer varies between observations when reporting more than once on the same material). Bias, Observer,Interobserver Variation,Intraobserver Variation,Observer Bias,Inter-Observer Variability,Inter-Observer Variation,Interobserver Variability,Intra-Observer Variability,Intra-Observer Variation,Intraobserver Variability,Inter Observer Variability,Inter Observer Variation,Inter-Observer Variabilities,Inter-Observer Variations,Interobserver Variabilities,Interobserver Variations,Intra Observer Variability,Intra Observer Variation,Intra-Observer Variabilities,Intra-Observer Variations,Intraobserver Variabilities,Intraobserver Variations,Observer Variations,Variabilities, Inter-Observer,Variabilities, Interobserver,Variabilities, Intra-Observer,Variabilities, Intraobserver,Variability, Inter-Observer,Variability, Interobserver,Variability, Intra-Observer,Variability, Intraobserver,Variation, Inter-Observer,Variation, Interobserver,Variation, Intra-Observer,Variation, Intraobserver,Variation, Observer,Variations, Inter-Observer,Variations, Interobserver,Variations, Intra-Observer,Variations, Intraobserver,Variations, Observer
D044963 Biopsy, Fine-Needle Using fine needles (finer than 22-gauge) to remove tissue or fluid specimens from the living body for examination in the pathology laboratory and for disease diagnosis. Aspiration Biopsy, Fine-Needle,Fine Needle Biopsy,Fine-Needle Aspiration,Aspiration Biopsies, Fine-Needle,Aspiration Biopsy, Fine Needle,Aspiration, Fine-Needle,Aspirations, Fine-Needle,Biopsies, Fine Needle,Biopsies, Fine-Needle,Biopsies, Fine-Needle Aspiration,Biopsy, Fine Needle,Biopsy, Fine-Needle Aspiration,Fine Needle Aspiration,Fine Needle Biopsies,Fine-Needle Aspiration Biopsies,Fine-Needle Aspiration Biopsy,Fine-Needle Aspirations,Fine-Needle Biopsies,Fine-Needle Biopsy,Needle Biopsies, Fine,Needle Biopsy, Fine
D060787 Neoplasm Grading Methods which attempt to express in replicable terms the level of CELL DIFFERENTIATION in neoplasms as increasing ANAPLASIA correlates with the aggressiveness of the neoplasm. Gleason Grading,Gleason Score,Tumor Grading,Grading, Gleason,Grading, Neoplasm,Grading, Tumor,Score, Gleason
D062005 Biopsy, Large-Core Needle The use of needles usually larger than 14-gauge to remove tissue samples large enough to retain cellular architecture for pathology examination. Biopsy, Core Needle,Core Needle Biopsy,Large-Core Needle Biopsy,Biopsies, Core Needle,Biopsies, Large-Core Needle,Biopsy, Large Core Needle,Core Needle Biopsies,Large Core Needle Biopsy,Large-Core Needle Biopsies,Needle Biopsies, Core,Needle Biopsies, Large-Core,Needle Biopsy, Core,Needle Biopsy, Large-Core

Related Publications

Lorenzo Marconi, and Saeed Dabestani, and Thomas B Lam, and Fabian Hofmann, and Fiona Stewart, and John Norrie, and Axel Bex, and Karim Bensalah, and Steven E Canfield, and Milan Hora, and Markus A Kuczyk, and Axel S Merseburger, and Peter F A Mulders, and Thomas Powles, and Michael Staehler, and Borje Ljungberg, and Alessandro Volpe
November 2016, European urology,
Lorenzo Marconi, and Saeed Dabestani, and Thomas B Lam, and Fabian Hofmann, and Fiona Stewart, and John Norrie, and Axel Bex, and Karim Bensalah, and Steven E Canfield, and Milan Hora, and Markus A Kuczyk, and Axel S Merseburger, and Peter F A Mulders, and Thomas Powles, and Michael Staehler, and Borje Ljungberg, and Alessandro Volpe
September 2011, Radiology,
Lorenzo Marconi, and Saeed Dabestani, and Thomas B Lam, and Fabian Hofmann, and Fiona Stewart, and John Norrie, and Axel Bex, and Karim Bensalah, and Steven E Canfield, and Milan Hora, and Markus A Kuczyk, and Axel S Merseburger, and Peter F A Mulders, and Thomas Powles, and Michael Staehler, and Borje Ljungberg, and Alessandro Volpe
June 2016, European urology,
Lorenzo Marconi, and Saeed Dabestani, and Thomas B Lam, and Fabian Hofmann, and Fiona Stewart, and John Norrie, and Axel Bex, and Karim Bensalah, and Steven E Canfield, and Milan Hora, and Markus A Kuczyk, and Axel S Merseburger, and Peter F A Mulders, and Thomas Powles, and Michael Staehler, and Borje Ljungberg, and Alessandro Volpe
July 2018, Current opinion in urology,
Lorenzo Marconi, and Saeed Dabestani, and Thomas B Lam, and Fabian Hofmann, and Fiona Stewart, and John Norrie, and Axel Bex, and Karim Bensalah, and Steven E Canfield, and Milan Hora, and Markus A Kuczyk, and Axel S Merseburger, and Peter F A Mulders, and Thomas Powles, and Michael Staehler, and Borje Ljungberg, and Alessandro Volpe
April 2023, Journal of magnetic resonance imaging : JMRI,
Lorenzo Marconi, and Saeed Dabestani, and Thomas B Lam, and Fabian Hofmann, and Fiona Stewart, and John Norrie, and Axel Bex, and Karim Bensalah, and Steven E Canfield, and Milan Hora, and Markus A Kuczyk, and Axel S Merseburger, and Peter F A Mulders, and Thomas Powles, and Michael Staehler, and Borje Ljungberg, and Alessandro Volpe
September 2014, Histopathology,
Lorenzo Marconi, and Saeed Dabestani, and Thomas B Lam, and Fabian Hofmann, and Fiona Stewart, and John Norrie, and Axel Bex, and Karim Bensalah, and Steven E Canfield, and Milan Hora, and Markus A Kuczyk, and Axel S Merseburger, and Peter F A Mulders, and Thomas Powles, and Michael Staehler, and Borje Ljungberg, and Alessandro Volpe
July 2022, Transplantation,
Lorenzo Marconi, and Saeed Dabestani, and Thomas B Lam, and Fabian Hofmann, and Fiona Stewart, and John Norrie, and Axel Bex, and Karim Bensalah, and Steven E Canfield, and Milan Hora, and Markus A Kuczyk, and Axel S Merseburger, and Peter F A Mulders, and Thomas Powles, and Michael Staehler, and Borje Ljungberg, and Alessandro Volpe
September 2015, International journal of evidence-based healthcare,
Lorenzo Marconi, and Saeed Dabestani, and Thomas B Lam, and Fabian Hofmann, and Fiona Stewart, and John Norrie, and Axel Bex, and Karim Bensalah, and Steven E Canfield, and Milan Hora, and Markus A Kuczyk, and Axel S Merseburger, and Peter F A Mulders, and Thomas Powles, and Michael Staehler, and Borje Ljungberg, and Alessandro Volpe
November 2018, BJU international,
Lorenzo Marconi, and Saeed Dabestani, and Thomas B Lam, and Fabian Hofmann, and Fiona Stewart, and John Norrie, and Axel Bex, and Karim Bensalah, and Steven E Canfield, and Milan Hora, and Markus A Kuczyk, and Axel S Merseburger, and Peter F A Mulders, and Thomas Powles, and Michael Staehler, and Borje Ljungberg, and Alessandro Volpe
November 2021, The British journal of radiology,
Copied contents to your clipboard!