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GS-5806 inhibits pre- to postfusion conformational changes of the respiratory syncytial virus fusion protein. 2015
Dharmaraj Samuel, and
Weimei Xing, and
Anita Niedziela-Majka, and
Jinny S Wong, and
Magdeleine Hung, and
Katherine M Brendza, and
Michel Perron, and
Robert Jordan, and
David Sperandio, and
Xiaohong Liu, and
Richard Mackman, and
Roman Sakowicz
Gilead Sciences, Inc., Foster City, California, USA dharmaraj.samuel@pfizer.com.
GS-5806 is a small-molecule inhibitor of human respiratory syncytial virus fusion protein-mediated viral entry. During viral entry, the fusion protein undergoes major conformational changes, resulting in fusion of the viral envelope with the host cell membrane. This process is reproduced in vitro using a purified, truncated respiratory syncytial virus (RSV) fusion protein. GS-5806 blocked these conformational changes, suggesting a possible mechanism for antiviral activity.
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