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2,2,2-Trifluoroethyl Chlorooxoacetate--Universal Reagent for One-Pot Parallel Synthesis of N(1)-Aryl-N(2)-alkyl-Substituted Oxamides. 2015
Andrey V Bogolubsky, and
Yurii S Moroz, and
Pavel K Mykhailiuk, and
Sergey E Pipko, and
Anton V Zhemera, and
Anzhelika I Konovets, and
Olena O Stepaniuk, and
Inna S Myronchuk, and
Yurii V Dmytriv, and
Roman A Doroschuk, and
Olga A Zaporozhets, and
Andrey Tolmachev
Enamine, Ltd. , 78 Chervonotkatska Street, Kyiv, 02094, Ukraine.
A one-pot parallel synthesis of N(1)-aryl-N(2)-alkyl-substituted oxamides with 2,2,2-trifluoroethyl chlorooxoacetate was developed. The synthesis of a library of 45 oxamides revealed higher efficiency of this reagent over the known ethyl chlorooxoacetate. The reagent was successfully used to prepare the known oxamide-containing HIV entry inhibitors.
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