Biomaterial Database

Nerve-mediated contractile and electrical activity of the guinea-pig choledocho-duodenal junction. 1989

F Vongalis, and R A Bywater, and G S Taylor

Department of Physiology, Monash University, Clayton, Victoria, Australia.

The intrinsic motor innervation of the guinea-pig choledocho-duodenal junction was investigated by recording the contractile and intracellular electrical activity of smooth muscle from different regions of this tissue. Electrical transmural nerve stimulation evoked phasic contractions in rings of muscle from the ampulla (0.45 s-1) and tonic contractions in rings of muscle from the choledochal sphincter. Intracellular microelectrode recordings from muscle strips from these two regions revealed that excitatory junction potentials (peak amplitude 7 mV) evoked by transmural nerve stimulation were more conspicuous in muscle strips from the choledochal sphincter, but inhibitory junction potentials (peak amplitude 13 mV) were of larger amplitude in muscle strips from the ampulla. Contractions and membrane depolarization evoked by transmural nerve stimulation were sensitive to 1.4 microM atropine and abolished by 3.1 microM tetrodotoxin. Histological studies on the choledocho-duodenal junction also revealed that the distribution of smooth muscle was non-uniform along the tissue. These results suggest that the two regions may have different functions in the motility of the choledocho-duodenal junction.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D009046	Motor Neurons	Neurons which activate MUSCLE CELLS.	Neurons, Motor,Alpha Motorneurons,Motoneurons,Motor Neurons, Alpha,Neurons, Alpha Motor,Alpha Motor Neuron,Alpha Motor Neurons,Alpha Motorneuron,Motoneuron,Motor Neuron,Motor Neuron, Alpha,Motorneuron, Alpha,Motorneurons, Alpha,Neuron, Alpha Motor,Neuron, Motor
D009119	Muscle Contraction	A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.	Inotropism,Muscular Contraction,Contraction, Muscle,Contraction, Muscular,Contractions, Muscle,Contractions, Muscular,Inotropisms,Muscle Contractions,Muscular Contractions
D009130	Muscle, Smooth	Unstriated and unstriped muscle, one of the muscles of the internal organs, blood vessels, hair follicles, etc. Contractile elements are elongated, usually spindle-shaped cells with centrally located nuclei. Smooth muscle fibers are bound together into sheets or bundles by reticular fibers and frequently elastic nets are also abundant. (From Stedman, 25th ed)	Muscle, Involuntary,Smooth Muscle,Involuntary Muscle,Involuntary Muscles,Muscles, Involuntary,Muscles, Smooth,Smooth Muscles
D003135	Common Bile Duct	The largest bile duct. It is formed by the junction of the CYSTIC DUCT and the COMMON HEPATIC DUCT.	Choledochus,Bile Duct, Common,Common Bile Ducts,Duct, Common Bile
D004386	Duodenum	The shortest and widest portion of the SMALL INTESTINE adjacent to the PYLORUS of the STOMACH. It is named for having the length equal to about the width of 12 fingers.	Duodenums
D004558	Electric Stimulation	Use of electric potential or currents to elicit biological responses.	Stimulation, Electric,Electrical Stimulation,Electric Stimulations,Electrical Stimulations,Stimulation, Electrical,Stimulations, Electric,Stimulations, Electrical
D005260	Female		Females
D006168	Guinea Pigs	A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.	Cavia,Cavia porcellus,Guinea Pig,Pig, Guinea,Pigs, Guinea
D000200	Action Potentials	Abrupt changes in the membrane potential that sweep along the CELL MEMBRANE of excitable cells in response to excitation stimuli.	Spike Potentials,Nerve Impulses,Action Potential,Impulse, Nerve,Impulses, Nerve,Nerve Impulse,Potential, Action,Potential, Spike,Potentials, Action,Potentials, Spike,Spike Potential