-transparent.png){kind=logo}
Thyroid Radiation Dose and Other Risk Factors of Thyroid Carcinoma Following Childhood Cancer. 2015
Florent de Vathaire, and
Nadia Haddy, and
Rodrigue S Allodji, and
Mike Hawkins, and
Catherine Guibout, and
Chiraz El-Fayech, and
Cécile Teinturier, and
Odile Oberlin, and
Hélène Pacquement, and
Fara Diop, and
Amar Kalhouche, and
Mohamedamine Benadjaoud, and
David Winter, and
Angela Jackson, and
Giao Bezin Mai-Quynh, and
Aymen Benabdennebi, and
Damien Llanas, and
Cristina Veres, and
Martine Munzer, and
Tan Dat Nguyen, and
Pierre-Yves Bondiau, and
Delphine Berchery, and
Anne Laprie, and
Eric Deutsch, and
Dimitri Lefkopoulos, and
Martin Schlumberger, and
Ibrahima Diallo, and
Carole Rubino
Radiation Epidemiology Group (F.d.V., N.H., R.S.A., C.G., C.E.-F., C.T., F.D., A.K., M.B., A.J., G.B.M.-Q., A.B., D.L., C.V., I.D., C.R.), INSERM U1018 Villejuif, F-94805, France; Institut Gustave Roussy (F.d.V., N.H., R.S.A., C.G., C.E.-F., C.T., O.O., F.D., A.K., M.B., A.J., G.B.M.-Q., A.B., D.L., C.V., E.D., D.L., M.S., I.D., C.R.), Villejuif, F-94805, France; Université Paris-Sud (F.d.V., N.H., R.S.A., C.G., C.E.-F., C.T., O.O., F.D., A.K., M.B., A.J., G.B.M.-Q., A.B., D.L., C.V., E.D., M.S., I.D., C.R.), Villejuif, F-94800, France; Centre for Childhood Cancer Survivor Studies, Department of Public Health & Epidemiology (M.H., D.W.), University of Birmingham, Birmingham B15 2TT, United Kingdom; Institut Curie (H.P.), Paris F-75005 Paris, France; Institut Jean Godinot (M.M., T.D.N.), F-51092 Reims, France; Centre Antoine Lacassagne (P.-Y.B.), F-06100 Nice, France; and Centre Claudius Régaud (D.B., A.L.), F-51100 Toulouse, France.
BACKGROUND Thyroid carcinoma is a frequent complication of childhood cancer radiotherapy. The dose response to thyroid radiation dose is now well established, but the potential modifier effect of other factors requires additional investigation. OBJECTIVE This study aimed to investigate the role of potential modifiers of the dose response. METHODS We followed a cohort of 4338 5-year survivors of solid childhood cancer treated before 1986 over an average of 27 years. The dose received by the thyroid gland and some other anatomical sites during radiotherapy was estimated after reconstruction of the actual conditions in which irradiation was delivered. RESULTS Fifty-five patients developed thyroid carcinoma. The risk of thyroid carcinoma increased with a radiation dose to the thyroid of up to two tenths of Gy, then leveled off for higher doses. When taking into account the thyroid radiation dose, a surgical or radiological splenectomy (>20 Gy to the spleen) increased thyroid cancer risk (relative risk [RR] = 2.3; 95% confidence interval [CI], 1.3-4.0), high radiation doses (>5 Gy) to pituitary gland lowered this risk (RR = 0.2; 95% CI, 0.1-0.6). Patients who received nitrosourea chemotherapy had a 6.6-fold (95% CI, 2.5-15.7) higher risk than those who did not. The excess RR per Gy of radiation to the thyroid was 4.7 (95% CI, 1.7-22.6). It was 7.6 (95% CI, 1.6-33.3) if body mass index at time of interview was equal or higher than 25 kg/m(2), and 4.1 (95% CI, 0.9-17.7) if not (P for interaction = .1). CONCLUSIONS Predicting thyroid cancer risk following childhood cancer radiation therapy probably requires the assessment of more than just the radiation dose to the thyroid. Chemotherapy, splenectomy, radiation dose to pituitary gland, and obesity also play a role.
Related Publications
Florent de Vathaire, and
Nadia Haddy, and
Rodrigue S Allodji, and
Mike Hawkins, and
Catherine Guibout, and
Chiraz El-Fayech, and
Cécile Teinturier, and
Odile Oberlin, and
Hélène Pacquement, and
Fara Diop, and
Amar Kalhouche, and
Mohamedamine Benadjaoud, and
David Winter, and
Angela Jackson, and
Giao Bezin Mai-Quynh, and
Aymen Benabdennebi, and
Damien Llanas, and
Cristina Veres, and
Martine Munzer, and
Tan Dat Nguyen, and
Pierre-Yves Bondiau, and
Delphine Berchery, and
Anne Laprie, and
Eric Deutsch, and
Dimitri Lefkopoulos, and
Martin Schlumberger, and
Ibrahima Diallo, and
Carole Rubino
December 1989,
Radiation research,
Florent de Vathaire, and
Nadia Haddy, and
Rodrigue S Allodji, and
Mike Hawkins, and
Catherine Guibout, and
Chiraz El-Fayech, and
Cécile Teinturier, and
Odile Oberlin, and
Hélène Pacquement, and
Fara Diop, and
Amar Kalhouche, and
Mohamedamine Benadjaoud, and
David Winter, and
Angela Jackson, and
Giao Bezin Mai-Quynh, and
Aymen Benabdennebi, and
Damien Llanas, and
Cristina Veres, and
Martine Munzer, and
Tan Dat Nguyen, and
Pierre-Yves Bondiau, and
Delphine Berchery, and
Anne Laprie, and
Eric Deutsch, and
Dimitri Lefkopoulos, and
Martin Schlumberger, and
Ibrahima Diallo, and
Carole Rubino
December 1977,
Cancer,
Florent de Vathaire, and
Nadia Haddy, and
Rodrigue S Allodji, and
Mike Hawkins, and
Catherine Guibout, and
Chiraz El-Fayech, and
Cécile Teinturier, and
Odile Oberlin, and
Hélène Pacquement, and
Fara Diop, and
Amar Kalhouche, and
Mohamedamine Benadjaoud, and
David Winter, and
Angela Jackson, and
Giao Bezin Mai-Quynh, and
Aymen Benabdennebi, and
Damien Llanas, and
Cristina Veres, and
Martine Munzer, and
Tan Dat Nguyen, and
Pierre-Yves Bondiau, and
Delphine Berchery, and
Anne Laprie, and
Eric Deutsch, and
Dimitri Lefkopoulos, and
Martin Schlumberger, and
Ibrahima Diallo, and
Carole Rubino
May 1983,
Postgraduate medicine,
Florent de Vathaire, and
Nadia Haddy, and
Rodrigue S Allodji, and
Mike Hawkins, and
Catherine Guibout, and
Chiraz El-Fayech, and
Cécile Teinturier, and
Odile Oberlin, and
Hélène Pacquement, and
Fara Diop, and
Amar Kalhouche, and
Mohamedamine Benadjaoud, and
David Winter, and
Angela Jackson, and
Giao Bezin Mai-Quynh, and
Aymen Benabdennebi, and
Damien Llanas, and
Cristina Veres, and
Martine Munzer, and
Tan Dat Nguyen, and
Pierre-Yves Bondiau, and
Delphine Berchery, and
Anne Laprie, and
Eric Deutsch, and
Dimitri Lefkopoulos, and
Martin Schlumberger, and
Ibrahima Diallo, and
Carole Rubino
July 2017,
The Journal of clinical endocrinology and metabolism,
Florent de Vathaire, and
Nadia Haddy, and
Rodrigue S Allodji, and
Mike Hawkins, and
Catherine Guibout, and
Chiraz El-Fayech, and
Cécile Teinturier, and
Odile Oberlin, and
Hélène Pacquement, and
Fara Diop, and
Amar Kalhouche, and
Mohamedamine Benadjaoud, and
David Winter, and
Angela Jackson, and
Giao Bezin Mai-Quynh, and
Aymen Benabdennebi, and
Damien Llanas, and
Cristina Veres, and
Martine Munzer, and
Tan Dat Nguyen, and
Pierre-Yves Bondiau, and
Delphine Berchery, and
Anne Laprie, and
Eric Deutsch, and
Dimitri Lefkopoulos, and
Martin Schlumberger, and
Ibrahima Diallo, and
Carole Rubino
January 1977,
Archives of pathology & laboratory medicine,
Florent de Vathaire, and
Nadia Haddy, and
Rodrigue S Allodji, and
Mike Hawkins, and
Catherine Guibout, and
Chiraz El-Fayech, and
Cécile Teinturier, and
Odile Oberlin, and
Hélène Pacquement, and
Fara Diop, and
Amar Kalhouche, and
Mohamedamine Benadjaoud, and
David Winter, and
Angela Jackson, and
Giao Bezin Mai-Quynh, and
Aymen Benabdennebi, and
Damien Llanas, and
Cristina Veres, and
Martine Munzer, and
Tan Dat Nguyen, and
Pierre-Yves Bondiau, and
Delphine Berchery, and
Anne Laprie, and
Eric Deutsch, and
Dimitri Lefkopoulos, and
Martin Schlumberger, and
Ibrahima Diallo, and
Carole Rubino
November 2003,
European journal of cancer (Oxford, England : 1990),
Florent de Vathaire, and
Nadia Haddy, and
Rodrigue S Allodji, and
Mike Hawkins, and
Catherine Guibout, and
Chiraz El-Fayech, and
Cécile Teinturier, and
Odile Oberlin, and
Hélène Pacquement, and
Fara Diop, and
Amar Kalhouche, and
Mohamedamine Benadjaoud, and
David Winter, and
Angela Jackson, and
Giao Bezin Mai-Quynh, and
Aymen Benabdennebi, and
Damien Llanas, and
Cristina Veres, and
Martine Munzer, and
Tan Dat Nguyen, and
Pierre-Yves Bondiau, and
Delphine Berchery, and
Anne Laprie, and
Eric Deutsch, and
Dimitri Lefkopoulos, and
Martin Schlumberger, and
Ibrahima Diallo, and
Carole Rubino
August 2009,
Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
Florent de Vathaire, and
Nadia Haddy, and
Rodrigue S Allodji, and
Mike Hawkins, and
Catherine Guibout, and
Chiraz El-Fayech, and
Cécile Teinturier, and
Odile Oberlin, and
Hélène Pacquement, and
Fara Diop, and
Amar Kalhouche, and
Mohamedamine Benadjaoud, and
David Winter, and
Angela Jackson, and
Giao Bezin Mai-Quynh, and
Aymen Benabdennebi, and
Damien Llanas, and
Cristina Veres, and
Martine Munzer, and
Tan Dat Nguyen, and
Pierre-Yves Bondiau, and
Delphine Berchery, and
Anne Laprie, and
Eric Deutsch, and
Dimitri Lefkopoulos, and
Martin Schlumberger, and
Ibrahima Diallo, and
Carole Rubino
June 1979,
Radiology,
Florent de Vathaire, and
Nadia Haddy, and
Rodrigue S Allodji, and
Mike Hawkins, and
Catherine Guibout, and
Chiraz El-Fayech, and
Cécile Teinturier, and
Odile Oberlin, and
Hélène Pacquement, and
Fara Diop, and
Amar Kalhouche, and
Mohamedamine Benadjaoud, and
David Winter, and
Angela Jackson, and
Giao Bezin Mai-Quynh, and
Aymen Benabdennebi, and
Damien Llanas, and
Cristina Veres, and
Martine Munzer, and
Tan Dat Nguyen, and
Pierre-Yves Bondiau, and
Delphine Berchery, and
Anne Laprie, and
Eric Deutsch, and
Dimitri Lefkopoulos, and
Martin Schlumberger, and
Ibrahima Diallo, and
Carole Rubino
May 1992,
Journal of clinical pathology,
Florent de Vathaire, and
Nadia Haddy, and
Rodrigue S Allodji, and
Mike Hawkins, and
Catherine Guibout, and
Chiraz El-Fayech, and
Cécile Teinturier, and
Odile Oberlin, and
Hélène Pacquement, and
Fara Diop, and
Amar Kalhouche, and
Mohamedamine Benadjaoud, and
David Winter, and
Angela Jackson, and
Giao Bezin Mai-Quynh, and
Aymen Benabdennebi, and
Damien Llanas, and
Cristina Veres, and
Martine Munzer, and
Tan Dat Nguyen, and
Pierre-Yves Bondiau, and
Delphine Berchery, and
Anne Laprie, and
Eric Deutsch, and
Dimitri Lefkopoulos, and
Martin Schlumberger, and
Ibrahima Diallo, and
Carole Rubino
March 2011,
Health physics,
