Olive Leaf Extract Improves the Atherogenic Lipid Profile in Rats Fed a High Cholesterol Diet. 2015

Ercument Olmez, and Kamil Vural, and Sule Gok, and Zeynep Ozturk, and Husniye Kayalar, and Semin Ayhan, and Ahmet Var
Celal Bayar University, Faculty of Medicine, Department of Medical Pharmacology, Manisa, Turkey.

Coronary heart disease because of atherosclerosis is still the most common cause of mortality. Elevated levels of low-density lipoprotein and total cholesterol are major risk factors for atherosclerotic cardiovascular disease. The aim of this study was to evaluate the effects of the olive leaf extract on serum lipid profile, early changes of atherosclerosis and endothelium-dependent relaxations in cholesterol-fed rats. For this purpose, rats were fed by 2% cholesterol-enriched or standard chow for 8 weeks. Some rats in each group were also fed orally by olive leaf extract at doses of 50 or 100 mg/kg/day. Atorvastatin at dose of 20 mg/kg of body weight daily was also given as positive control. After 8 weeks, lipid profiles of rat serums were analyzed. Antioxidant enzyme activities (superoxide dismutase and glutathione peroxidase) and degree of lipid peroxidation (malondialdehyde levels) were also measured in the hearts isolated from rats. In addition, expression of adhesion molecules and endothelium-dependent relaxations of isolated thoracic aortas of rats were evaluated. Total cholesterol and LDL-cholesterol levels were found to be increased in cholesterol-fed rats, and both doses of olive leaf extract and atorvastatin significantly decreased those levels. In conclusion, because the olive leaf extract attenuates the increased cholesterol levels, it may have beneficial effects on atherosclerosis.

UI MeSH Term Description Entries
D008055 Lipids A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed) Lipid
D008077 Lipoproteins, LDL A class of lipoproteins of small size (18-25 nm) and light (1.019-1.063 g/ml) particles with a core composed mainly of CHOLESTEROL ESTERS and smaller amounts of TRIGLYCERIDES. The surface monolayer consists mostly of PHOSPHOLIPIDS, a single copy of APOLIPOPROTEIN B-100, and free cholesterol molecules. The main LDL function is to transport cholesterol and cholesterol esters to extrahepatic tissues. Low-Density Lipoprotein,Low-Density Lipoproteins,beta-Lipoprotein,beta-Lipoproteins,LDL(1),LDL(2),LDL-1,LDL-2,LDL1,LDL2,Low-Density Lipoprotein 1,Low-Density Lipoprotein 2,LDL Lipoproteins,Lipoprotein, Low-Density,Lipoproteins, Low-Density,Low Density Lipoprotein,Low Density Lipoprotein 1,Low Density Lipoprotein 2,Low Density Lipoproteins,beta Lipoprotein,beta Lipoproteins
D008297 Male Males
D008315 Malondialdehyde The dialdehyde of malonic acid. Malonaldehyde,Propanedial,Malonylaldehyde,Malonyldialdehyde,Sodium Malondialdehyde,Malondialdehyde, Sodium
D010936 Plant Extracts Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard. Herbal Medicines,Plant Extract,Extract, Plant,Extracts, Plant,Medicines, Herbal
D002784 Cholesterol The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils. Epicholesterol
D004036 Diet, Atherogenic A diet that contributes to the development and acceleration of ATHEROGENESIS. Atherogenic Diet,Atherogenic Diets,Diets, Atherogenic
D005979 Glutathione Peroxidase An enzyme catalyzing the oxidation of 2 moles of GLUTATHIONE in the presence of HYDROGEN PEROXIDE to yield oxidized glutathione and water. Cytosolic Glutathione Peroxidase,Glutathione Lipoperoxidase,Selenoglutathione Peroxidase,Glutathione Peroxidase, Cytosolic,Lipoperoxidase, Glutathione,Peroxidase, Glutathione,Peroxidase, Selenoglutathione
D006937 Hypercholesterolemia A condition with abnormally high levels of CHOLESTEROL in the blood. It is defined as a cholesterol value exceeding the 95th percentile for the population. Hypercholesteremia,Elevated Cholesterol,High Cholesterol Levels,Cholesterol Level, High,Cholesterol Levels, High,Cholesterol, Elevated,Cholesterols, Elevated,Elevated Cholesterols,High Cholesterol Level,Hypercholesteremias,Hypercholesterolemias,Level, High Cholesterol,Levels, High Cholesterol
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

Related Publications

Ercument Olmez, and Kamil Vural, and Sule Gok, and Zeynep Ozturk, and Husniye Kayalar, and Semin Ayhan, and Ahmet Var
March 2011, Journal of physiology and biochemistry,
Ercument Olmez, and Kamil Vural, and Sule Gok, and Zeynep Ozturk, and Husniye Kayalar, and Semin Ayhan, and Ahmet Var
December 2013, Journal of physiology and biochemistry,
Ercument Olmez, and Kamil Vural, and Sule Gok, and Zeynep Ozturk, and Husniye Kayalar, and Semin Ayhan, and Ahmet Var
October 2008, Bioscience, biotechnology, and biochemistry,
Ercument Olmez, and Kamil Vural, and Sule Gok, and Zeynep Ozturk, and Husniye Kayalar, and Semin Ayhan, and Ahmet Var
January 2016, Journal of nutritional science and vitaminology,
Ercument Olmez, and Kamil Vural, and Sule Gok, and Zeynep Ozturk, and Husniye Kayalar, and Semin Ayhan, and Ahmet Var
August 2018, Nutrition research and practice,
Ercument Olmez, and Kamil Vural, and Sule Gok, and Zeynep Ozturk, and Husniye Kayalar, and Semin Ayhan, and Ahmet Var
October 2022, Heliyon,
Ercument Olmez, and Kamil Vural, and Sule Gok, and Zeynep Ozturk, and Husniye Kayalar, and Semin Ayhan, and Ahmet Var
October 2015, BMC complementary and alternative medicine,
Ercument Olmez, and Kamil Vural, and Sule Gok, and Zeynep Ozturk, and Husniye Kayalar, and Semin Ayhan, and Ahmet Var
April 2016, European review for medical and pharmacological sciences,
Ercument Olmez, and Kamil Vural, and Sule Gok, and Zeynep Ozturk, and Husniye Kayalar, and Semin Ayhan, and Ahmet Var
June 2017, Asian Pacific journal of tropical medicine,
Ercument Olmez, and Kamil Vural, and Sule Gok, and Zeynep Ozturk, and Husniye Kayalar, and Semin Ayhan, and Ahmet Var
April 2010, Phytotherapy research : PTR,
Copied contents to your clipboard!