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The participation of the heart in shock syndrome formation during endotoxin shock is a problem still awaiting solution. The task undertaken is to assess the work of the left ventricle and arterial pressure in rabbits before and after endotoxin injection at a dose of 2 mg.kg-1. Heart rate is the first to reach significantly lower values--at 30 min (p less than 0.05). At 45 min, there are significant reductions in dP/dtmax (p less than 0.01), (dp/dt)/P40 (p less than 0.001), LVP (p less than 0.05), and increase in dP/dtneg (p less than 0.02). Both the systolic and diastolic blood pressures were significantly decreased at 60 min. The data obtained warrant the assumption that impaired myocardial contractility plays a part in the formation of shock syndrome in rabbits exposed to endotoxin.
Z Velkov, and
R Lolov, and
T Yoshikawa, and
N Nicolov
June 1997,
American journal of respiratory and critical care medicine,
Z Velkov, and
R Lolov, and
T Yoshikawa, and
N Nicolov
March 1970,
The American journal of physiology,
Z Velkov, and
R Lolov, and
T Yoshikawa, and
N Nicolov
October 1985,
The American journal of physiology,
Z Velkov, and
R Lolov, and
T Yoshikawa, and
N Nicolov
February 1988,
Circulatory shock,
Z Velkov, and
R Lolov, and
T Yoshikawa, and
N Nicolov
December 1992,
Journal of applied physiology (Bethesda, Md. : 1985),
Z Velkov, and
R Lolov, and
T Yoshikawa, and
N Nicolov
January 1994,
Pediatric research,
Z Velkov, and
R Lolov, and
T Yoshikawa, and
N Nicolov
February 1982,
The American journal of physiology,
Z Velkov, and
R Lolov, and
T Yoshikawa, and
N Nicolov
November 1988,
Cardiovascular research,
Z Velkov, and
R Lolov, and
T Yoshikawa, and
N Nicolov
November 1989,
Journal of the American College of Cardiology,
Z Velkov, and
R Lolov, and
T Yoshikawa, and
N Nicolov
August 1997,
The American journal of physiology,
