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Immunoreactive relaxin was measured in plasma samples obtained from human volunteers utilizing the RIA procedure of Sherwood et al., as modified by O'Byrne and Steinetz for heterologous plasma samples. Immunoreactive hormone was not detected in samples obtained from men, and only rarely in plasma of nonpregnant women. Immunoreactive relaxin was present as early as the fourth week of pregnancy and was detectable throughout the course of gestation. Immunoreactive relaxin tended to be higher early in pregnancy, and there was no peak just before parturition as occurs in many other species. Our results are at variance with those of Bryant and coworkers, who reported high levels of immunoreactive relaxin in men and nonpregnant as well as pregnant women. The possible reasons for this discrepancy are presented.
E M O'Byrne, and
B T Carriere, and
L Sorensen, and
A Segaloff, and
C Schwabe, and
B G Steinetz
November 1975,
Clinica chimica acta; international journal of clinical chemistry,
E M O'Byrne, and
B T Carriere, and
L Sorensen, and
A Segaloff, and
C Schwabe, and
B G Steinetz
October 1987,
Biology of reproduction,
E M O'Byrne, and
B T Carriere, and
L Sorensen, and
A Segaloff, and
C Schwabe, and
B G Steinetz
September 1983,
The Journal of clinical endocrinology and metabolism,
E M O'Byrne, and
B T Carriere, and
L Sorensen, and
A Segaloff, and
C Schwabe, and
B G Steinetz
January 1990,
Comparative biochemistry and physiology. A, Comparative physiology,
E M O'Byrne, and
B T Carriere, and
L Sorensen, and
A Segaloff, and
C Schwabe, and
B G Steinetz
January 1959,
Annals of the New York Academy of Sciences,
E M O'Byrne, and
B T Carriere, and
L Sorensen, and
A Segaloff, and
C Schwabe, and
B G Steinetz
November 2000,
Free radical research,
E M O'Byrne, and
B T Carriere, and
L Sorensen, and
A Segaloff, and
C Schwabe, and
B G Steinetz
September 1986,
Anesthesia and analgesia,
E M O'Byrne, and
B T Carriere, and
L Sorensen, and
A Segaloff, and
C Schwabe, and
B G Steinetz
August 1957,
Obstetrics and gynecology,
E M O'Byrne, and
B T Carriere, and
L Sorensen, and
A Segaloff, and
C Schwabe, and
B G Steinetz
January 1986,
Biological research in pregnancy and perinatology,
E M O'Byrne, and
B T Carriere, and
L Sorensen, and
A Segaloff, and
C Schwabe, and
B G Steinetz
January 1989,
International journal of fertility,
