BIOMAT Database Logo BIOMAT Database Logo

[Effect of long-term treatment with propranolol or hydrochlorothiazide on biochemical risk factors of coronary disease in patients with hypertension]. 1989

M Witkowska, and S Lukasik, and M Kawecka, and J Moszczyńska, and B Karolko

In 59 patients with mild or moderate essential hypertension effects of propranolol and hydrochlorothiazide on serum lipids, fibrynogen, glucose and uric acid concentrations as well as serum euglobulins fibrynolysis time were studied. 36 patients received propranolol and 23 subjects hydrochlorothiazide. Follow-up time was 1 year. Statistically significant increases of serum triglycerides, fibrynogen, levels and total cholesterol/HDL cholesterol LDH/HDL indices in comparison with their initial values were stated in a propranolol group. Significant serum cholesterol increase after 6 month therapy was the most substantial metabolic change in a hydrochlorothiazide group. Alterations of lipids indices in both groups were especially intensive in patients with pretreatment stated disturbances of lipids metabolism.

UI MeSH Term Description Entries
D006973 Hypertension Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more. Blood Pressure, High,Blood Pressures, High,High Blood Pressure,High Blood Pressures
D008055 Lipids A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed) Lipid
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011433 Propranolol A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs. Dexpropranolol,AY-20694,Anaprilin,Anapriline,Avlocardyl,Betadren,Dociton,Inderal,Obsidan,Obzidan,Propanolol,Propranolol Hydrochloride,Rexigen,AY 20694,AY20694,Hydrochloride, Propranolol
D003327 Coronary Disease An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels. Coronary Heart Disease,Coronary Diseases,Coronary Heart Diseases,Disease, Coronary,Disease, Coronary Heart,Diseases, Coronary,Diseases, Coronary Heart,Heart Disease, Coronary,Heart Diseases, Coronary
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D006852 Hydrochlorothiazide A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism. Dichlothiazide,Dihydrochlorothiazide,Esidrex,Esidrix,HCTZ,HydroDIURIL,Hypothiazide,Oretic,Sectrazide

Related Publications

M Witkowska, and S Lukasik, and M Kawecka, and J Moszczyńska, and B Karolko
[Does chronic therapy of hypertension with acebutolol or hydrochlorothiazide effect coronary risk factors?].
January 1991, Kardiologia polska,
M Witkowska, and S Lukasik, and M Kawecka, and J Moszczyńska, and B Karolko
[Effect of long-term hydrochlorothiazide treatment on the hemodynamics of patients with primary arterial hypertension].
January 1987, Kardiologia polska,
M Witkowska, and S Lukasik, and M Kawecka, and J Moszczyńska, and B Karolko
Nicardipine or propranolol combined with hydrochlorothiazide in patients with essential hypertension.
January 1993, Proceedings of the Western Pharmacology Society,
M Witkowska, and S Lukasik, and M Kawecka, and J Moszczyńska, and B Karolko
Long term effect of timolol and hydrochlorothiazide, or hydrochlorothiazide and amiloride, in essential hypertension.
October 1977, European journal of clinical pharmacology,
M Witkowska, and S Lukasik, and M Kawecka, and J Moszczyńska, and B Karolko
Furosemide compared with hydrochlorothiazide. Long-term treatment of hypertension.
October 1978, JAMA,
M Witkowska, and S Lukasik, and M Kawecka, and J Moszczyńska, and B Karolko
Comparison of benazepril plus amlodipine or hydrochlorothiazide in high-risk patients with hypertension and coronary artery disease.
July 2013, The American journal of cardiology,
M Witkowska, and S Lukasik, and M Kawecka, and J Moszczyńska, and B Karolko
Reactivity to mental stress and cold provocation during long-term treatment with metoprolol, propranolol or hydrochlorothiazide.
December 1986, Journal of hypertension. Supplement : official journal of the International Society of Hypertension,
M Witkowska, and S Lukasik, and M Kawecka, and J Moszczyńska, and B Karolko
Effect on finger tremor of withdrawal of long-term treatment with propranolol or atenolol.
September 1984, British journal of clinical pharmacology,
M Witkowska, and S Lukasik, and M Kawecka, and J Moszczyńska, and B Karolko
Long-term propranolol treatment of resistant arterial hypertension in haemodialysed patients.
June 1975, Clinical science and molecular medicine. Supplement,
M Witkowska, and S Lukasik, and M Kawecka, and J Moszczyńska, and B Karolko
Synergistic effect of coronary artery disease risk factors on long-term survival in patients with normal exercise SPECT studies.
April 2011, Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology,
Copied contents to your clipboard!