BIOMAT Database Logo BIOMAT Database Logo

T-cell repertoire and thymus. 1989

P Marrack, and M Blackman, and H G Burgert, and J M McCormack, and J Cambier, and T H Finkel, and J Kappler
Howard Hughes Medical Institute, Denver, Colorado.

UI MeSH Term Description Entries
D008285 Major Histocompatibility Complex The genetic region which contains the loci of genes which determine the structure of the serologically defined (SD) and lymphocyte-defined (LD) TRANSPLANTATION ANTIGENS, genes which control the structure of the IMMUNE RESPONSE-ASSOCIATED ANTIGENS, HUMAN; the IMMUNE RESPONSE GENES which control the ability of an animal to respond immunologically to antigenic stimuli, and genes which determine the structure and/or level of the first four components of complement. Histocompatibility Complex,Complex, Histocompatibility,Complex, Major Histocompatibility,Complices, Histocompatibility,Complices, Major Histocompatibility,Histocompatibility Complex, Major,Histocompatibility Complices,Histocompatibility Complices, Major,Major Histocompatibility Complices
D011948 Receptors, Antigen, T-Cell Molecules on the surface of T-lymphocytes that recognize and combine with antigens. The receptors are non-covalently associated with a complex of several polypeptides collectively called CD3 antigens (CD3 COMPLEX). Recognition of foreign antigen and the major histocompatibility complex is accomplished by a single heterodimeric antigen-receptor structure, composed of either alpha-beta (RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA) or gamma-delta (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA) chains. Antigen Receptors, T-Cell,T-Cell Receptors,Receptors, T-Cell Antigen,T-Cell Antigen Receptor,T-Cell Receptor,Antigen Receptor, T-Cell,Antigen Receptors, T Cell,Receptor, T-Cell,Receptor, T-Cell Antigen,Receptors, T Cell Antigen,Receptors, T-Cell,T Cell Antigen Receptor,T Cell Receptor,T Cell Receptors,T-Cell Antigen Receptors
D002454 Cell Differentiation Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs. Differentiation, Cell,Cell Differentiations,Differentiations, Cell
D002999 Clone Cells A group of genetically identical cells all descended from a single common ancestral cell by mitosis in eukaryotes or by binary fission in prokaryotes. Clone cells also include populations of recombinant DNA molecules all carrying the same inserted sequence. (From King & Stansfield, Dictionary of Genetics, 4th ed) Clones,Cell, Clone,Cells, Clone,Clone,Clone Cell
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012641 Selection, Genetic Differential and non-random reproduction of different genotypes, operating to alter the gene frequencies within a population. Natural Selection,Genetic Selection,Selection, Natural
D013601 T-Lymphocytes Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen. T Cell,T Lymphocyte,T-Cells,Thymus-Dependent Lymphocytes,Cell, T,Cells, T,Lymphocyte, T,Lymphocyte, Thymus-Dependent,Lymphocytes, T,Lymphocytes, Thymus-Dependent,T Cells,T Lymphocytes,T-Cell,T-Lymphocyte,Thymus Dependent Lymphocytes,Thymus-Dependent Lymphocyte
D013950 Thymus Gland A single, unpaired primary lymphoid organ situated in the MEDIASTINUM, extending superiorly into the neck to the lower edge of the THYROID GLAND and inferiorly to the fourth costal cartilage. It is necessary for normal development of immunologic function early in life. By puberty, it begins to involute and much of the tissue is replaced by fat. Thymus,Gland, Thymus,Glands, Thymus,Thymus Glands
D051379 Mice The common name for the genus Mus. Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus

Related Publications

P Marrack, and M Blackman, and H G Burgert, and J M McCormack, and J Cambier, and T H Finkel, and J Kappler
Apoptosis and T-cell repertoire selection in the thymus.
November 1992, Annals of the New York Academy of Sciences,
P Marrack, and M Blackman, and H G Burgert, and J M McCormack, and J Cambier, and T H Finkel, and J Kappler
Using thymus anatomy to dissect T cell repertoire selection.
February 1999, Seminars in immunology,
P Marrack, and M Blackman, and H G Burgert, and J M McCormack, and J Cambier, and T H Finkel, and J Kappler
Human T cell repertoire: what happens in thymus does not stay in thymus.
May 2019, The Journal of clinical investigation,
P Marrack, and M Blackman, and H G Burgert, and J M McCormack, and J Cambier, and T H Finkel, and J Kappler
Review article: thymus organ cultures and T-cell receptor repertoire development.
August 2000, Immunology,
P Marrack, and M Blackman, and H G Burgert, and J M McCormack, and J Cambier, and T H Finkel, and J Kappler
Studying T-cell repertoire selection using fetal thymus organ culture.
January 2007, Methods in molecular biology (Clifton, N.J.),
P Marrack, and M Blackman, and H G Burgert, and J M McCormack, and J Cambier, and T H Finkel, and J Kappler
T cell receptor/MHC interactions in the thymus and the shaping of the T cell repertoire.
December 1987, Transplantation proceedings,
P Marrack, and M Blackman, and H G Burgert, and J M McCormack, and J Cambier, and T H Finkel, and J Kappler
Gamma delta T-cell receptor repertoire in human peripheral blood and thymus.
January 1990, Immunogenetics,
P Marrack, and M Blackman, and H G Burgert, and J M McCormack, and J Cambier, and T H Finkel, and J Kappler
Antigen processing and presentation in the thymus: implications for T cell repertoire selection.
June 2017, Current opinion in immunology,
P Marrack, and M Blackman, and H G Burgert, and J M McCormack, and J Cambier, and T H Finkel, and J Kappler
A kinetic window constricts the T cell receptor repertoire in the thymus.
March 2001, Immunity,
P Marrack, and M Blackman, and H G Burgert, and J M McCormack, and J Cambier, and T H Finkel, and J Kappler
Dynamics of thymus function and T cell receptor repertoire breadth in health and disease.
February 2021, Seminars in immunopathology,
Copied contents to your clipboard!