[Primary melanoma of the oral cavity]. 1989

E Vairaktaris, and I Iatrou, and V Ragos, and K Petraki, and C Martis

Melanoma most often develops in the skin; usually at the site of a preexisting nevus. It is quite rare in the oral cavity and the maxilla is the most common location there. It appears that males between 60 and 70 years old are affected more often than females. The etiology is unknown. However the melachromatic nevus and the color of the skin are considered predisposing factors. Based on clinical and histologic criteria it is classified in three categories. Unfortunately the frequency of the occurrence of each category into the mouth separately, is inversely proportional to the prognosis. The 5 year survival rate of intraoral melanoma does not exceed 5-9%. The treatment of melanoma is surgical and comprises radical excision of the lesion and radical neck dissection. Radiotherapy and chemotherapy do not seem to contribute to the treatment. We present our experience of two patients with melanoma of the maxilla. In one case submandibular lymphadenopathy had already been established and a radical neck dissection was performed. In the other case subtotal maxillectomy was performed with intraoral approach.

UI MeSH Term Description Entries
D008297 Male Males
D008441 Maxillary Neoplasms Cancer or tumors of the MAXILLA or upper jaw. Maxillary Neoplasm,Neoplasm, Maxillary,Neoplasms, Maxillary
D008545 Melanoma A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445) Malignant Melanoma,Malignant Melanomas,Melanoma, Malignant,Melanomas,Melanomas, Malignant
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D015996 Survival Rate The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods. Cumulative Survival Rate,Mean Survival Time,Cumulative Survival Rates,Mean Survival Times,Rate, Cumulative Survival,Rate, Survival,Rates, Cumulative Survival,Rates, Survival,Survival Rate, Cumulative,Survival Rates,Survival Rates, Cumulative,Survival Time, Mean,Survival Times, Mean,Time, Mean Survival,Times, Mean Survival
D037981 Neck Dissection Dissection in the neck to remove all disease tissues including cervical LYMPH NODES and to leave an adequate margin of normal tissue. This type of surgery is usually used in tumors or cervical metastases in the head and neck. The prototype of neck dissection is the radical neck dissection described by Crile in 1906. Radical Neck Dissection,Dissection, Neck,Dissection, Radical Neck,Dissections, Neck,Dissections, Radical Neck,Neck Dissection, Radical,Neck Dissections,Neck Dissections, Radical,Radical Neck Dissections

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