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New methodology to analyze posterior vitreous fluorophotometry (PVF) data is described. Values for D, fluorescein vitreous diffusion coefficient and P, permeability of the blood retinal barrier (BRB) to fluorescein are obtained. D was found to be significantly greater in diabetic patients with minimal retinopathy compared with either controls or patients with no retinopathy. P values were not significantly different between diabetic patients and controls or between diabetic subgroups, confirming the absence of breakdown of the BRB, as assessed by PVF, in early diabetic retinopathy.
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