Breathing pattern during pharmacological activation and blockade of the intermediate area of the ventrolateral surface of the cat medulla. 1989

F R Silva, and Campos RR Júnior, and E Freire, and P G Guertzenstein, and I C Piçarro, and L O Rodrigues, and A K Russo, and A C Silva, and J Tarasantchi
Departamento de Fisiologia, Escola Paulista de Medicina, São Paulo, Brasil.

The present study analyzes the respiratory pattern of chloralose-(50-60 mg/kg, iv) anesthetized cats treated with Nembutal (NE) (30 mg/ml), glycine (GL) (200 mg/ml) or leptazol (LE) (200 mg/ml) topically applied to the intermediate area of the ventrolateral surface of the medulla oblongata in a volume of 20 microliters. Application of NE and GL produced a decrease in ventilation (approximately 24%) and tidal volume (approximately 25%) suggesting that the intermediate area facilitates respiratory drive and inhibits the inspiratory off-switch mechanism. These results are consistent with the view that intermediate area is necessary for the central chemosensitivity to CO2. The topical application of LE produced an increase in inspiration time (12.5%), expiration time (20.8%) and tidal volume (7%). The increased tidal volume caused by LE is compatible with its action as a GL antagonist.

UI MeSH Term Description Entries
D008176 Lung Volume Measurements Measurement of the amount of air that the lungs may contain at various points in the respiratory cycle. Lung Capacities,Lung Volumes,Capacity, Lung,Lung Capacity,Lung Volume,Lung Volume Measurement,Measurement, Lung Volume,Volume, Lung
D008526 Medulla Oblongata The lower portion of the BRAIN STEM. It is inferior to the PONS and anterior to the CEREBELLUM. Medulla oblongata serves as a relay station between the brain and the spinal cord, and contains centers for regulating respiratory, vasomotor, cardiac, and reflex activities. Accessory Cuneate Nucleus,Ambiguous Nucleus,Arcuate Nucleus of the Medulla,Arcuate Nucleus-1,External Cuneate Nucleus,Lateral Cuneate Nucleus,Nucleus Ambiguus,Ambiguus, Nucleus,Arcuate Nucleus 1,Arcuate Nucleus-1s,Cuneate Nucleus, Accessory,Cuneate Nucleus, External,Cuneate Nucleus, Lateral,Medulla Oblongatas,Nucleus, Accessory Cuneate,Nucleus, Ambiguous,Nucleus, External Cuneate,Nucleus, Lateral Cuneate
D010424 Pentobarbital A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236) Mebubarbital,Mebumal,Diabutal,Etaminal,Ethaminal,Nembutal,Pentobarbital Sodium,Pentobarbital, Monosodium Salt,Pentobarbitone,Sagatal,Monosodium Salt Pentobarbital
D010433 Pentylenetetrazole A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility. Leptazole,Pentamethylenetetrazole,Pentetrazole,Cardiazol,Corasol,Corazol,Corazole,Korazol,Korazole,Metrazol,Metrazole,Pentazol,Pentylenetetrazol
D012119 Respiration The act of breathing with the LUNGS, consisting of INHALATION, or the taking into the lungs of the ambient air, and of EXHALATION, or the expelling of the modified air which contains more CARBON DIOXIDE than the air taken in (Blakiston's Gould Medical Dictionary, 4th ed.). This does not include tissue respiration ( Breathing
D012125 Respiratory Center Part of the brain located in the MEDULLA OBLONGATA and PONS. It receives neural, chemical and hormonal signals, and controls the rate and depth of respiratory movements of the DIAPHRAGM and other respiratory muscles. Center, Respiratory,Centers, Respiratory,Respiratory Centers
D002415 Cats The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801) Felis catus,Felis domesticus,Domestic Cats,Felis domestica,Felis sylvestris catus,Cat,Cat, Domestic,Cats, Domestic,Domestic Cat
D005998 Glycine A non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter. Aminoacetic Acid,Glycine, Monopotassium Salt,Glycine Carbonate (1:1), Monosodium Salt,Glycine Carbonate (2:1), Monolithium Salt,Glycine Carbonate (2:1), Monopotassium Salt,Glycine Carbonate (2:1), Monosodium Salt,Glycine Hydrochloride,Glycine Hydrochloride (2:1),Glycine Phosphate,Glycine Phosphate (1:1),Glycine Sulfate (3:1),Glycine, Calcium Salt,Glycine, Calcium Salt (2:1),Glycine, Cobalt Salt,Glycine, Copper Salt,Glycine, Monoammonium Salt,Glycine, Monosodium Salt,Glycine, Sodium Hydrogen Carbonate,Acid, Aminoacetic,Calcium Salt Glycine,Cobalt Salt Glycine,Copper Salt Glycine,Hydrochloride, Glycine,Monoammonium Salt Glycine,Monopotassium Salt Glycine,Monosodium Salt Glycine,Phosphate, Glycine,Salt Glycine, Monoammonium,Salt Glycine, Monopotassium,Salt Glycine, Monosodium
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013990 Tidal Volume The volume of air inspired or expired during each normal, quiet respiratory cycle. Common abbreviations are TV or V with subscript T. Tidal Volumes,Volume, Tidal,Volumes, Tidal

Related Publications

F R Silva, and Campos RR Júnior, and E Freire, and P G Guertzenstein, and I C Piçarro, and L O Rodrigues, and A K Russo, and A C Silva, and J Tarasantchi
June 1991, Brain research,
F R Silva, and Campos RR Júnior, and E Freire, and P G Guertzenstein, and I C Piçarro, and L O Rodrigues, and A K Russo, and A C Silva, and J Tarasantchi
February 1988, Brain research,
F R Silva, and Campos RR Júnior, and E Freire, and P G Guertzenstein, and I C Piçarro, and L O Rodrigues, and A K Russo, and A C Silva, and J Tarasantchi
April 1985, Brain research,
F R Silva, and Campos RR Júnior, and E Freire, and P G Guertzenstein, and I C Piçarro, and L O Rodrigues, and A K Russo, and A C Silva, and J Tarasantchi
August 1992, The American journal of physiology,
F R Silva, and Campos RR Júnior, and E Freire, and P G Guertzenstein, and I C Piçarro, and L O Rodrigues, and A K Russo, and A C Silva, and J Tarasantchi
August 1994, Neuroscience letters,
F R Silva, and Campos RR Júnior, and E Freire, and P G Guertzenstein, and I C Piçarro, and L O Rodrigues, and A K Russo, and A C Silva, and J Tarasantchi
March 2008, Neuroscience research,
F R Silva, and Campos RR Júnior, and E Freire, and P G Guertzenstein, and I C Piçarro, and L O Rodrigues, and A K Russo, and A C Silva, and J Tarasantchi
August 1976, Pflugers Archiv : European journal of physiology,
F R Silva, and Campos RR Júnior, and E Freire, and P G Guertzenstein, and I C Piçarro, and L O Rodrigues, and A K Russo, and A C Silva, and J Tarasantchi
June 1985, Brain research,
F R Silva, and Campos RR Júnior, and E Freire, and P G Guertzenstein, and I C Piçarro, and L O Rodrigues, and A K Russo, and A C Silva, and J Tarasantchi
May 1999, Journal of the autonomic nervous system,
F R Silva, and Campos RR Júnior, and E Freire, and P G Guertzenstein, and I C Piçarro, and L O Rodrigues, and A K Russo, and A C Silva, and J Tarasantchi
June 1991, Brain research,
Copied contents to your clipboard!