Biomaterial Database

Experimental allergic alveolitis after inhalation of mouldy hay. 1989

B Fogelmark, and R Rylander, and J Lacey

Department of Environmental Hygiene, University of Gothenburg, Sweden.

Guinea pigs were exposed by inhalation to an aerosol of dust from mouldy hay or cell bound bacterial endotoxins. Pulmonary histology and free lung cells were evaluated 24 hr after exposures lasting from one day to five weeks. In animals exposed to mouldy hay, there was a progressive increase in the number of macrophages and neutrophils and after three weeks a sharp increase in lymphocytes. Following endotoxin exposure, neutrophils increased greatly in number with one day's exposure but after longer exposures, numbers differed little from normal, suggesting adaptation. Histopathology of lungs from animals exposed to mouldy hay demonstrated the presence of alveolar cell infiltrates and early granulomas, that were similar to allergic alveolitis (AA). This model for AA could be used both to assess the importance of different agents in mouldy hay and to evaluate the risk of AA from new kinds of organic dusts.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D004195	Disease Models, Animal	Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	Animal Disease Model,Animal Disease Models,Disease Model, Animal
D004731	Endotoxins	Toxins closely associated with the living cytoplasm or cell wall of certain microorganisms, which do not readily diffuse into the culture medium, but are released upon lysis of the cells.	Endotoxin
D005260	Female		Females
D005658	Fungi	A kingdom of eukaryotic, heterotrophic organisms that live parasitically as saprobes, including MUSHROOMS; YEASTS; smuts, molds, etc. They reproduce either sexually or asexually, and have life cycles that range from simple to complex. Filamentous fungi, commonly known as molds, refer to those that grow as multicellular colonies.	Fungi, Filamentous,Molds,Filamentous Fungi,Filamentous Fungus,Fungus,Fungus, Filamentous,Mold
D006109	Poaceae	A large family of narrow-leaved herbaceous grasses of the order Cyperales, subclass Commelinidae, class Liliopsida (monocotyledons). Food grains (EDIBLE GRAIN) come from members of this family. RHINITIS, ALLERGIC, SEASONAL can be induced by POLLEN of many of the grasses.	Alopecurus,Arundo,Gramineae,Grasses,Imperata,Grass,Imperata cylindrica
D006168	Guinea Pigs	A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.	Cavia,Cavia porcellus,Guinea Pig,Pig, Guinea,Pigs, Guinea
D000336	Aerosols	Colloids with a gaseous dispersing phase and either liquid (fog) or solid (smoke) dispersed phase; used in fumigation or in inhalation therapy; may contain propellant agents.	Aerosol
D000485	Allergens	Antigen-type substances that produce immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).	Allergen
D000542	Alveolitis, Extrinsic Allergic	A common interstitial lung disease caused by hypersensitivity reactions of PULMONARY ALVEOLI after inhalation of and sensitization to environmental antigens of microbial, animal, or chemical sources. The disease is characterized by lymphocytic alveolitis and granulomatous pneumonitis.	Allergic Alveolitis, Extrinsic,Hypersensitivity Pneumonitis,Pneumonitis, Hypersensitivity,Allergic Alveolitides, Extrinsic,Alveolitides, Extrinsic Allergic,Extrinsic Allergic Alveolitides,Extrinsic Allergic Alveolitis,Hypersensitivity Pneumonitides,Pneumonitides, Hypersensitivity