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We measured the action of dopamine given intravenously at dosage ranging from 2.5 to 320 micrograms/kg per min in closed chest anaesthetized dogs. Dopamine produced a dose-dependent increase in heart rate, cardiac index, mean arterial pressure, total peripheral resistance, pulmonary artery pressure, left ventricular end diastolic pressure, coronary flow and myocardial oxygen consumption. At dopamine dosage of 80-320 micrograms/kg per min, the coronary vascular resistance, the stroke volume index, the efficiency of heart work and the central venous pressure are all decreased. The maximum effect of dopamine on the circulation was seen at a dose between 40 and 80 micrograms/kg per min.
J B Brückner, and
W Hess, and
D Schmidt, and
E Schneider, and
E Schweichel
January 1989,
Masui. The Japanese journal of anesthesiology,
J B Brückner, and
W Hess, and
D Schmidt, and
E Schneider, and
E Schweichel
September 1990,
Chest,
J B Brückner, and
W Hess, and
D Schmidt, and
E Schneider, and
E Schweichel
October 2005,
The Journal of experimental biology,
J B Brückner, and
W Hess, and
D Schmidt, and
E Schneider, and
E Schweichel
August 1990,
Canadian journal of physiology and pharmacology,
J B Brückner, and
W Hess, and
D Schmidt, and
E Schneider, and
E Schweichel
January 1980,
Coeur et medecine interne,
J B Brückner, and
W Hess, and
D Schmidt, and
E Schneider, and
E Schweichel
January 1981,
Bulletin europeen de physiopathologie respiratoire,
J B Brückner, and
W Hess, and
D Schmidt, and
E Schneider, and
E Schweichel
August 1964,
The American journal of physiology,
J B Brückner, and
W Hess, and
D Schmidt, and
E Schneider, and
E Schweichel
April 1995,
The Journal of veterinary medical science,
J B Brückner, and
W Hess, and
D Schmidt, and
E Schneider, and
E Schweichel
January 1985,
Advances in experimental medicine and biology,
J B Brückner, and
W Hess, and
D Schmidt, and
E Schneider, and
E Schweichel
March 1976,
American heart journal,
